AS/RS based yard and yard planning

In this paper, we apply the split-platform automated storage/retrieval systems (SP-AS/RSs) (Hu et al., 2005) to store containers in the yard to improve the yard performance and to increase the utilization of the yard space. The layout of an SP-AS/RS based yard is described in detail. To achieve an efficient operation, we present a novel yard space allocation policy called the ‘second-carrier-based allocation policy’, which can help to alleviate the out-of-sequence problem of containers and the congestion of vehicles at the AS/RS racks. Different allocation policies are compared by an integrated container terminal simulation system. The simulation results show that the second-carrier-based policy is very efficient and has the potential to offer high terminal performance.

Solutions to Nonlocal Integrable Discrete Nonlinear Schr?dinger Equations via Reduction

Solutions to local and nonlocal integrable discrete nonlinear Schrodinger（IDNLS） equations are studied via reduction on the bilinear form. It is shown that these solutions to IDNLS equations can be expressed in terms of the single Casorati determinant under different constraint conditions.

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine,fasudil,imatinib,and caspofungin as potential treatments for lethal COVID-19

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019(COVID-19)severity and lethality.However,drugs that are effective against inflammation to treat lethal COVID-19 are still urgently needed.Here,we constructed a SARS-CoV-2 spike protein-specific CAR,and human T cells infected with this CAR(SARS-CoV-2-S CAR-T)and stimulated with spike protein mimicked the T-cell responses seen in COVID-19 patients,causing cytokine storm and displaying a distinct memory,exhausted,and regulatory T-cell phenotype.THP1 remarkably augmented cytokine release in SARS-CoV-2-S CAR-T cells when they were in coculture.Based on this"two-cell"(CAR-T and THP1 cells)model,we screened an FDA-approved drug library and found that felodipine,fasudil,imatinib,and caspofungin were effective in suppressing the release of cytokines,which was likely due to their ability to suppress the NF-kB pathway in vitro.Felodipine,fasudi,imatinib,and caspofungin were further demonstrated,although to different extents,to attenuate lethal inflammation,ameliorate severe pneumonia,and prevent mortality in a SARS-CoV-2-infected Syrian hamster model,which were also linked to their suppressive role in inflammation.In summary,we established a SARS-CoV-2-specific CAR-T-cell model that can be utilized as a tool for anti-inflammatory drug screening in a fast and high-throughput manner.The drugs identified herein have great potential for early treatment to prevent COVID-19 patients from cytokine storm-induced lethality in the clinic because they are safe,inexpensive,and easily accessible for immediateuseinmostcountries.

Residual Symmetry of the Alice-Bob Modified Korteweg-de Vries Equation

Starting from the truncated Painlev′e expansion, the residual symmetry of the Alice-Bob modified Kortewegde Vries(AB-mKdV) equation is derived. The residual symmetry is localized and the AB-mKdV equation is transformed into an enlarged system by introducing one new variable. Based on Lie's first theorem, the finite transformation is obtained from the localized residual symmetry. Further, considering the linear superposition of multiple residual symmetries gives rises to N-th B?cklund transformation in the form of the determinant. Moreover, the P_sT_d(the shifted parity and delayed time reversal) symmetric exact solutions(including invariant solution, breaking solution and breaking interaction solution) of AB-mKdV equation are presented and two classes of interaction solutions are depicted by using the particular functions with numerical simulation.