Three modified sine-Hilbert(sH)-type equations, i.e., the modified sH equation, the modified damped sH equation, and the modified nonlinear dissipative system, are proposed, and their bilinear forms are provided.Based...Three modified sine-Hilbert(sH)-type equations, i.e., the modified sH equation, the modified damped sH equation, and the modified nonlinear dissipative system, are proposed, and their bilinear forms are provided.Based on these bilinear equations, some exact solutions to the three modified equations are derived.展开更多
Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are...Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault.The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging.Efficient pretreatment methods followed by accurate and sensitive detections are necessary.Herein,pretreatment methods for the extraction,enrichment,and preconcentration of BDZs as well as the strategies for their screening,identification,and quantitation developed in the past five years have been reviewed.Moreover,recent advances in various methods are summarized.Characteristics and advantages of each method are encompassed.Future directions of the pretreatment and detection methods for BDZs are also reviewed.展开更多
We investigated the hydrolysis of TiⅣ along with naturally abundant AlⅢ ions and reported the formation of a stable and semiconducting nanocluster. Interestingly, this compound exhibits an unusual odd-membered ring ...We investigated the hydrolysis of TiⅣ along with naturally abundant AlⅢ ions and reported the formation of a stable and semiconducting nanocluster. Interestingly, this compound exhibits an unusual odd-membered ring structure and also represents the largest Al-containing polyoxotitanium cluster(PTC) observed thus far. The presence of a shell of organic ligands as well as the incorporation of hetero-AlⅢ ions endowed the nanocluster with high air, thermal, and pH stabilities. The present compound exhibited a record photocatalytic hydrogen evolution of 402.88 μmol g–1 h–1 among PTC materials. This work not only paves the way towards stable PTC materials but also provides new insights into the design of novel photocatalysts.展开更多
The synthesis of heterometallic aluminum-based materials is challenging yet attractive,due to their potential applications in optics,catalysis,magnetism and semiconductor device.We have now successfully synthesized tw...The synthesis of heterometallic aluminum-based materials is challenging yet attractive,due to their potential applications in optics,catalysis,magnetism and semiconductor device.We have now successfully synthesized two Al,Niz heterometallic clusters bearing different peripheral alkoxide ligands through a heterometal substitution strategy.展开更多
Based on our discovery of neutral aluminum molecular rings,we herein introduce rare earth ions into the center of the ring and reveal their structural adaptability.The resulting yoyo-like cationic macrocycles are high...Based on our discovery of neutral aluminum molecular rings,we herein introduce rare earth ions into the center of the ring and reveal their structural adaptability.The resulting yoyo-like cationic macrocycles are highly adaptive to guests,creating unusual supramolecular assemblies.The first category is stacked with singly oriented rhombohedral channels,which exhibit fast and reversible solvent-triggered molecular motions and structural rearrangements.The second type of assembly is that yoyo macrocycles and guest molecules form a nested host-guest sodalite cage supramolecular structure.It is uncommon for guest molecules to be well-defined within cages although caged structures have been well-documented.Their host-guest interaction discussion reveals the self-adaptation and flexibility of the yoyo macrocycles.Considering their good water stability,we investigated their anion exchange properties.The results show that they have significant exchange capacity for KI/I_(2),ReO_(4)^(-),and MnO_(4)^(-),revealing their potential application in water purification and nuclear waste treatment.展开更多
Patients with lung cancer may experience various symptoms as the disease progresses,which may reduce the benefits of cancer treatment,reduce treatment compliance,delay cancer treatment,reduce the quality of life(QoL),...Patients with lung cancer may experience various symptoms as the disease progresses,which may reduce the benefits of cancer treatment,reduce treatment compliance,delay cancer treatment,reduce the quality of life(QoL),and impact survival.This review discusses comprehensive symptom assessment and management,which are crucial for high-quality lung cancer treatment.Traditional Chinese medicine(TCM)is important in relieving cancer-related symptoms in patients with lung cancer.Including patient-reported outcomes(PROs)in clinical trials and practice can provide a better assessment of symptom burden and the effectiveness of symptom management.Patient-centered care with TCM in lung cancer patients may include six steps:Symptom screening,etiology investigation,comprehensive assessment,integrative management,reassessment,and regular symptom follow-up monitoring.PRO measures can be used to evaluate symptom intensity,the degree to which symptoms interfere with activities of daily living,and the QoL.Clearly defined and reliable PRO measures can enhance patient satisfaction and improve symptom control.Quantitative PRO measures developed from the TCM perspective should be considered one of the important outcome measurements in TCM care.A multidisciplinary collaborative symptom management model,including TCM and conventional therapy,will be the future goal for treating patients with lung cancer.展开更多
It is of great interest to modulate the photophysical properties by atomically precise chemical control.The incorporation of conjugated ligands into crystalline materials provides a platform for molecular-level interp...It is of great interest to modulate the photophysical properties by atomically precise chemical control.The incorporation of conjugated ligands into crystalline materials provides a platform for molecular-level interpretation of the structure-activity relationship.Herein,we reported the phenol-thermal and scale-up synthesis of a new family of remarkably stable aluminum molecular rings.They are assembled by twenty Al^(Ⅲ) ions with large conjugated ligands and phenols,representing the currently largest sizes(up to 4 nm in diameter)in the field of main group metal oxo clusters.Phenols are not only reaction medium but also auxiliary bridging ligands on the surface of macrocyclic molecules.In addition,they are either parallel to the center of the molecular ring or inserted into the molecular ring,or form dimers/tetramers that bind macrocyclic molecules to form supramolecular structures.These macrocyclic rings are hydrophobic and ultra-stable,evidenced by retaining their morphology and crystalline when exposed to air for more than a year.Compared with the pristine conjugated ligands,they exhibit coordination-enhanced fluorescence.By dispersing them into a polydimethylsiloxane(PDMS)matrix,we prepared transparent and flexible PDMS thin films for coupling flexible display and nonlinear optical application.Our discovery of such atomically precise rings provides a platform for the fine-tuning of photo-related performances.展开更多
Porcine epidemic diarrhea virus（PEDV） is a highly infectious pathogen that can cause severe diseases in pigs and result in enormous economic losses in the worldwide swine industry. Previous studies revealed that PED...Porcine epidemic diarrhea virus（PEDV） is a highly infectious pathogen that can cause severe diseases in pigs and result in enormous economic losses in the worldwide swine industry. Previous studies revealed that PEDV exhibits an obvious capacity for modulating interferon（IFN） signaling or expression. The newly discovered type III IFN, which plays a crucial role in antiviral immunity, has strong antiviral activity against PEDV proliferation in IPEC-J2 cells. In this study, we aimed to investigate the effect of PEDV nucleocapsid（N） protein on type III IFN-λ. We found that the N proteins of ten PEDV strains isolated between 2013 and 2017 from different local farms shared high nucleotide identities, while the N protein of the CV777 vaccine strain formed a monophyletic branch in the phylogenetic tree. The N protein of the epidemic strain could antagonize type III IFN, but not type I or type II IFN expression induced by polyinosinic-polycytidylic acid（poly（I：C）） in IPEC-J2 cells. Subsequently, we demonstrated that the inhibition of poly（I：C）-induced IFN-λ3 production by PEDV N protein was dependent on the blocking of nuclear factor-κB（NF-κB） nuclear translocation. These findings might help increase understanding of the pathogenesis of PEDV and its mechanisms for evading the host immune response.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 11931017 and 12071447)。
文摘Three modified sine-Hilbert(sH)-type equations, i.e., the modified sH equation, the modified damped sH equation, and the modified nonlinear dissipative system, are proposed, and their bilinear forms are provided.Based on these bilinear equations, some exact solutions to the three modified equations are derived.
基金supported by the Scientific Research Project of the Department of Education of Liaoning Province,China(Grant No.:ZF2019036).
文摘Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault.The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging.Efficient pretreatment methods followed by accurate and sensitive detections are necessary.Herein,pretreatment methods for the extraction,enrichment,and preconcentration of BDZs as well as the strategies for their screening,identification,and quantitation developed in the past five years have been reviewed.Moreover,recent advances in various methods are summarized.Characteristics and advantages of each method are encompassed.Future directions of the pretreatment and detection methods for BDZs are also reviewed.
文摘We investigated the hydrolysis of TiⅣ along with naturally abundant AlⅢ ions and reported the formation of a stable and semiconducting nanocluster. Interestingly, this compound exhibits an unusual odd-membered ring structure and also represents the largest Al-containing polyoxotitanium cluster(PTC) observed thus far. The presence of a shell of organic ligands as well as the incorporation of hetero-AlⅢ ions endowed the nanocluster with high air, thermal, and pH stabilities. The present compound exhibited a record photocatalytic hydrogen evolution of 402.88 μmol g–1 h–1 among PTC materials. This work not only paves the way towards stable PTC materials but also provides new insights into the design of novel photocatalysts.
基金This work is supported by the National Natural Science Foundation of China(92061104,21935010 and 21973096)the Natural Science Foundation of Fujian Province(2021J06035)the Youth Innovation Promotion Association CAS(Y2018081).
文摘The synthesis of heterometallic aluminum-based materials is challenging yet attractive,due to their potential applications in optics,catalysis,magnetism and semiconductor device.We have now successfully synthesized two Al,Niz heterometallic clusters bearing different peripheral alkoxide ligands through a heterometal substitution strategy.
基金supported by the National Natural Science Foundation of China(92061104,21771181,21935010)the Natural Science Foundation of Fujian Province(2021J06035)the Youth Innovation Promotion Association CAS(2017345,Y2018081)。
文摘Based on our discovery of neutral aluminum molecular rings,we herein introduce rare earth ions into the center of the ring and reveal their structural adaptability.The resulting yoyo-like cationic macrocycles are highly adaptive to guests,creating unusual supramolecular assemblies.The first category is stacked with singly oriented rhombohedral channels,which exhibit fast and reversible solvent-triggered molecular motions and structural rearrangements.The second type of assembly is that yoyo macrocycles and guest molecules form a nested host-guest sodalite cage supramolecular structure.It is uncommon for guest molecules to be well-defined within cages although caged structures have been well-documented.Their host-guest interaction discussion reveals the self-adaptation and flexibility of the yoyo macrocycles.Considering their good water stability,we investigated their anion exchange properties.The results show that they have significant exchange capacity for KI/I_(2),ReO_(4)^(-),and MnO_(4)^(-),revealing their potential application in water purification and nuclear waste treatment.
基金financially supported by the Capital Clinical Characteristic Application Research Project of the Beijing Science and Technology Commission(No.Z181100001718175)the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(No.CI2021A05502)。
文摘Patients with lung cancer may experience various symptoms as the disease progresses,which may reduce the benefits of cancer treatment,reduce treatment compliance,delay cancer treatment,reduce the quality of life(QoL),and impact survival.This review discusses comprehensive symptom assessment and management,which are crucial for high-quality lung cancer treatment.Traditional Chinese medicine(TCM)is important in relieving cancer-related symptoms in patients with lung cancer.Including patient-reported outcomes(PROs)in clinical trials and practice can provide a better assessment of symptom burden and the effectiveness of symptom management.Patient-centered care with TCM in lung cancer patients may include six steps:Symptom screening,etiology investigation,comprehensive assessment,integrative management,reassessment,and regular symptom follow-up monitoring.PRO measures can be used to evaluate symptom intensity,the degree to which symptoms interfere with activities of daily living,and the QoL.Clearly defined and reliable PRO measures can enhance patient satisfaction and improve symptom control.Quantitative PRO measures developed from the TCM perspective should be considered one of the important outcome measurements in TCM care.A multidisciplinary collaborative symptom management model,including TCM and conventional therapy,will be the future goal for treating patients with lung cancer.
基金National Natural Science Foundation of China,Grant/Award Number:92061104Natural Science Foundation of Fujian Province,Grant/Award Number:2021J06035Youth Innovation Promotion Association of the Chinese Academy of Sciences,Grant/Award Numbers:Y2018081,2017345。
文摘It is of great interest to modulate the photophysical properties by atomically precise chemical control.The incorporation of conjugated ligands into crystalline materials provides a platform for molecular-level interpretation of the structure-activity relationship.Herein,we reported the phenol-thermal and scale-up synthesis of a new family of remarkably stable aluminum molecular rings.They are assembled by twenty Al^(Ⅲ) ions with large conjugated ligands and phenols,representing the currently largest sizes(up to 4 nm in diameter)in the field of main group metal oxo clusters.Phenols are not only reaction medium but also auxiliary bridging ligands on the surface of macrocyclic molecules.In addition,they are either parallel to the center of the molecular ring or inserted into the molecular ring,or form dimers/tetramers that bind macrocyclic molecules to form supramolecular structures.These macrocyclic rings are hydrophobic and ultra-stable,evidenced by retaining their morphology and crystalline when exposed to air for more than a year.Compared with the pristine conjugated ligands,they exhibit coordination-enhanced fluorescence.By dispersing them into a polydimethylsiloxane(PDMS)matrix,we prepared transparent and flexible PDMS thin films for coupling flexible display and nonlinear optical application.Our discovery of such atomically precise rings provides a platform for the fine-tuning of photo-related performances.
基金Project supported by the National Natural Science Foundation of China(No.31702250)the Key Research and Development Project Funds of Zhejiang Provincial Science and Technology Department(Nos.2015C02044 and 2018C02028)+2 种基金the Agricultural Technology Extension Funds of Zhejiang Universitythe Dabei Agricultural Discipline Development and Talent Training Fund(No.2017ZDNT004)the Three Rural and Six Party Funds,China
文摘Porcine epidemic diarrhea virus（PEDV） is a highly infectious pathogen that can cause severe diseases in pigs and result in enormous economic losses in the worldwide swine industry. Previous studies revealed that PEDV exhibits an obvious capacity for modulating interferon（IFN） signaling or expression. The newly discovered type III IFN, which plays a crucial role in antiviral immunity, has strong antiviral activity against PEDV proliferation in IPEC-J2 cells. In this study, we aimed to investigate the effect of PEDV nucleocapsid（N） protein on type III IFN-λ. We found that the N proteins of ten PEDV strains isolated between 2013 and 2017 from different local farms shared high nucleotide identities, while the N protein of the CV777 vaccine strain formed a monophyletic branch in the phylogenetic tree. The N protein of the epidemic strain could antagonize type III IFN, but not type I or type II IFN expression induced by polyinosinic-polycytidylic acid（poly（I：C）） in IPEC-J2 cells. Subsequently, we demonstrated that the inhibition of poly（I：C）-induced IFN-λ3 production by PEDV N protein was dependent on the blocking of nuclear factor-κB（NF-κB） nuclear translocation. These findings might help increase understanding of the pathogenesis of PEDV and its mechanisms for evading the host immune response.
