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紫檀芪对骨质疏松大鼠牙种植体骨整合的机制研究
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作者 冯亚梅 杨鹏 赵海蛟 《药物流行病学杂志》 CAS 2023年第6期662-670,共9页
目的探究紫檀芪对骨质疏松大鼠牙种植体骨整合的影响以及可能的作用机制。方法采用去势法建立骨质疏松大鼠模型,造模成功后进行牙种植体植入。将牙种植体植入成功大鼠随机分为模型组、紫檀芪低(20 mg·kg^(-1))、中(40 mg·kg^(... 目的探究紫檀芪对骨质疏松大鼠牙种植体骨整合的影响以及可能的作用机制。方法采用去势法建立骨质疏松大鼠模型,造模成功后进行牙种植体植入。将牙种植体植入成功大鼠随机分为模型组、紫檀芪低(20 mg·kg^(-1))、中(40 mg·kg^(-1))、高(80 mg·kg^(-1))剂量组,每组12只;另取12只不去势大鼠作为假手术组。紫檀芪各剂量组灌胃给药,模型组与假手术组给予等体积生理盐水,1次/d,连续给药12周。采用micro-CT扫描仪进行种植区骨组织分析,亚甲基蓝-酸性品红染色观察种植区骨组织形态变化以及骨愈合情况,采用扭矩测试仪测定种植区骨组织脱位扭矩,免疫组化法检测种植区骨组织中肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)表达,Western blot法检测种植区骨组织中骨形态发生蛋白2(BMP-2)、Runt相关转录因子2(Runx2)蛋白表达。结果与假手术组比较,模型组大鼠种植体与股骨结合不够紧密,结合处骨板较薄,骨小梁间隙大,且数量较少;种植区股骨骨体积分数(BV/TV)、骨小梁数量(Tb.N)和骨结合指数(OI)、种植体骨结合率与松质骨区骨量以及脱位扭矩均显著降低(P<0.05),骨小梁间隙(Tb.Sp)显著升高(P<0.05),种植区骨组织中TNF-α、IL-1β表达均显著升高(P<0.05),BMP-2、Runx2表达均显著降低(P<0.05)。与模型组比较,紫檀芪各剂量组大鼠种植体骨结合逐渐紧密,骨小梁数量逐渐增加,间隙变小,骨板增厚;大鼠种植区股骨BV/TV、Tb.N和OI、种植体骨结合率与松质骨区骨量以及脱位扭矩均显著升高(P<0.05),Tb.Sp显著降低(P<0.05),种植区骨组织中TNF-α、IL-1β表达均显著降低(P<0.05),BMP-2、Runx2表达均显著升高(P<0.05),且不同剂量组间上述指标的差异均有统计学意义(P<0.05)。结论紫檀芪可通过减轻骨质疏松引起的炎症反应,上调成骨因子BMP-2、Runx2表达,在骨质疏松状态下对牙种植体骨整合具有良好的促进作用。 展开更多
关键词 紫檀芪 骨质疏松 牙种植体 骨整合
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Depth-aided inpainting for disocclusion restoration of multi-view images using depth-image-based rendering 被引量:7
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作者 Kai LUO Dong-xiao LI +1 位作者 ya-mei feng Ming ZHANG 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2009年第12期1738-1749,共12页
A new algorithm is proposed for restoring disocclusion regions in depth-image-based rendering (DIBR) warped images. Current solutions include layered depth image (LDI), pre-filtering methods, and post-processing m... A new algorithm is proposed for restoring disocclusion regions in depth-image-based rendering (DIBR) warped images. Current solutions include layered depth image (LDI), pre-filtering methods, and post-processing methods. The LDI is complicated, and pre-filtering of depth images causes noticeable geometrical distortions in cases of large baseline warping. This paper presents a depth-aided inpainting method which inherits merits from Criminisi's inpainting algorithm. The proposed method features incorporation of a depth cue into texture estimation. The algorithm efficiently handles depth ambiguity by penalizing larger Lagrange multipliers of flling points closer to the warping position compared with the surrounding existing points. We perform morphological operations on depth images to accelerate the algorithm convergence, and adopt a luma-first strategy to adapt to various color sampling formats. Experiments on test multi-view sequence showed that our method has superiority in depth differentiation and geometrical loyalty in the restoration of warped images. Also, peak signal-to-noise ratio (PSNR) statistics on non-hole regions and whole image comparisons both compare favorably to those obtained by state of the art techniques. 展开更多
关键词 Depth-aided inpainting Disocclusion restoration Depth-image-based rendering (DIBR) Image warping Stereoscopic image Multi-view image 3D-TV
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