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Concentration-dependent effects of reductive pulmonary inhalants on ultrafine particle-induced oxidative stress:Insights for health risk assessment
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作者 ya-qi yu Tong Zhu 《Environmental Science and Ecotechnology》 SCIE 2024年第3期118-124,共7页
The impact of reductive pulmonary inhalants on ultrafine particles(UFPs)-induced pulmonary oxidative stress remains a crucial consideration,yet the concentration-dependent effects of these inhalants have remained unex... The impact of reductive pulmonary inhalants on ultrafine particles(UFPs)-induced pulmonary oxidative stress remains a crucial consideration,yet the concentration-dependent effects of these inhalants have remained unexplored.Here we synthesized composite UFPs simulating atmospheric UFPs,primarily composed of metals and quinones.We subjected these UFPs to varying concentrations(0e7000 mM)of two reductive pulmonary inhalants,N-acetylcysteine and salbutamol,to assess their influence on oxidative potential,measured through the dithiothreitol assay(OP^(DTT)).Simultaneously,we analysed the soluble metal content of UFPs to uncover potential relationships between oxidative potential and metal solubility.Our results unveil a dual role played by these inhalants in shaping the OPDTT of composite UFPs.Specifically,OP^(DTT) generally increased as inhalant concentrations rose from 0 to 300 mM.However,an intriguing reversal occurred when concentrations exceeded 500 mM,resulting in a decline in OPDTT.Relative to untreated UFPs,these inhalants induced promotion and inhibition effects within concentration ranges of 100e500 and>1000 mM,respectively.While no significant correlation emerged between OP^(DTT) and soluble metal content as inhalant concentrations ranged from 0 to 7000 mM,noteworthy positive correlations emerged at lower inhalant concentrations(e.g.,N-acetylcysteine at 0 e300 mM).These findings provide insights into the potential influence of reductive pulmonary inhalants on health risks associated with UFP exposure,further underscoring the need for continued research in this critical area. 展开更多
关键词 Concentration-dependent effects Oxidative potential Reductive pulmonary inhalants Soluble metals Simulated atmospheric ultrafine particles
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