Reaction Characteristics of Polysaccharide-Iodine Complexes: A Mini-review

The potential reactions between natural polysaccharides and iodine and their products have been explored for a long time. Due to the complex factors that can in？uence these reactions, a clear-cut mechanism has not yet been developed. Starch-iodine complexes, especially the amylose-iodine complex, are the most investigated of the polysaccharide-iodine reactions, and the study of this reaction can be used as a basis for the investigation of other polysaccharide-iodine reactions. In this paper, significant aspects of the reaction were introduced, including the influence of the polysaccharide structure on the properties of the resulting complexes, the relationship between the concentration of CaCl2 and formation of the final products, as well as the form of the polyiodides in these complexes. The interior structure and the surface morphology of the complexes were discussed, along with the progress in research related to this reaction.

The Guangdong Mode of Integration of Science-Education and Industry-Education for Postgraduates in Engineering

Based on the theory of collaborative innovation and the triple helix theory combined with the needs for innovative development in the modern manufacturing industry in Guangdong Province,the construction of open bases as education carriers by the governments was explored in terms of implement joint training for postgraduates in engineering through the integration of science-education and industry-education,to improve the practical innovation ability of postgraduates in engineering.The integration training mode has significantly improved the effectiveness of collaborative education and innovation,and it has become an important talent and intellectual support for Guangdong’s modern manufacturing industry.It has further advanced the theory and practice of joint training conducted by governments,industries,universities,and scientific research institutes.

Research on the Diversified Mentoring Models for Open Base Engineering Graduates-A Case Study of Foshan

The key to guaranteeing the quality of engineering graduate cultivation lies in establishing a dual mentorship model,involving both,universities and enterprises.By analyzing the existing problems in dual mentorship for engineering graduates,the open base for joint graduate cultivation in Foshan is taken as an example.Under the“2+2”diversified mentoring model constructed for engineering practice cultivation,an open base guarantees the implementation of the diversified mentoring model,while the diversified mentoring model improves the effectiveness of collaborative education between universities and enterprises.Strengthening the qualification examination of collaborative education and reinforcing the academic ability training of enterprise mentors are proposed as strategies for the problems faced in the implementation.

Reform and Practice of an Engineering Postgraduate Training Pattern in an Open-Ended Base:Taking Foshan Base as an Example

The flawed engineering practice is considered the main factor that is affecting to the development quality of engineering postgraduates.Taking Foshan Base as an example,this paper has analyzed the operational pattern,practice teaching model,and internal governance system of the open-ended base as a new system for engineering practice and proposed several suggestions for the reformation of engineering postgraduates based on the construction effect.

Helicobacter pylori and immunotherapy for gastrointestinal cancer

Helicobacter pylori infection is associated with the risk of gastrointestinal(GI)cancers;however,its impact on immunotherapy for GI cancers remains uncertain.In this study,we included 10,122 patients who underwent ^(13)C-urea breath tests.Among 636 patients with Epstein-Barr virus–negative microsatellite-stable gastric cancer(GC)who were treated with anti-PD-1/PD-L1 therapy,H.pylori–positive patients exhibited significantly longer immune-related progression-free survival(irPFS)compared with H.pylori–negative patients(6.97 months versus 5.03 months,p<0.001,hazard ratio[HR]0.76,95%confidence interval[CI]0.62–0.95,p=0.015).Moreover,the H.pylori–positive group demonstrated a trend of 4 months longer median immune-related overall survival(irOS)than the H.pylori–negative group.H.pylori–positive GC displayed higher densities of PD-L1+cells and nonexhausted CD8+T cells,indicative of a“hot”tumor microenvironment.Transcriptomic analysis revealed that H.pylori–positive GC shared molecular characteristics similar to those of immunotherapy-sensitive GC.However,H.pylori–positive patients with DNA mismatch repair–deficient(dMMR)/microsatellite instability–high(MSI-H)colorectal adenocarcinoma and esophageal squamous cell carcinoma(ESCC)had shorter irPFS compared with H.pylori–negative patients(16.13 months versus not reached,p=0.042,HR 2.26,95%CI 1.13–4.50,p=0.021 and 5.57 months versus 6.97 months,p=0.029,HR 1.59,95%CI 1.14–2.23,p=0.006,respectively).The difference in irOS between H.pylori–positive and–negative patients had the same trend as that between dMMR/MSI-H colorectal adenocarcinoma and ESCC patients.We also identified a trend of shorter irPFS and irOS in H.pylori–positive liver cancer and pancreatic cancer patients.In summary,our findings supported that H.pylori infection is a beneficial factor for GC immunotherapy by shaping hot tumor microenvironments.However,in dMMR/MSI-H colorectal adenocarcinoma and ESCC patients,H.pylori adversely affects the efficacy of immunotherapy.

Integrated radiative and evaporative cooling beyond daytime passive cooling power limit

Radiative cooling technologies can passively gain lower temperature than that of ambient surroundings without consuming electricity,which has emerged as potential alternatives to traditional cooling methods.However,the limitations in daytime radiation intensity with a net cooling power of less than 150 W·m^(−2) have hindered progress toward commercial practicality.Here,we report an integrated radiative and evaporative chiller(IREC)based on polyacrylamide hydrogels combined with an upper layer of breathable poly(vinylidene fluoride-co-trifluoroethylene)fibers,which achieves a record high practical average daytime cooling power of 710 W·m^(−2).The breathable fiber layer has an average emissivity of over 76%in the atmospheric window,while reflecting 90%of visible light.This IREC possesses effective daytime radiative cooling while simultaneously ensuring evaporative cooling capability,enhancing daytime passive cooling effectively.As a result,IREC presents the practicability for both personal cooling managements and industrial auxiliary cooling applications.An IREC-based patch can assist in cooling human body by 13℃ low for a long term and biocompatible use,and IREC can maintain the temperature of industrial storage facilities such as oil tanks at room temperature even under strong sunlight irradiation.This work delivers the highest performance daytime passive cooling by simultaneous infrared radiation and water evaporation,and provides a new perspective for developing highly efficient,scalable,and affordable passive cooling strategy.