Microcirculatory dysfunction(CMD)typically occurs in patients with acute ST-segment elevation myocardial infarction during percutaneous coronary intervention,which is associated with more severe myocardial injury and ...Microcirculatory dysfunction(CMD)typically occurs in patients with acute ST-segment elevation myocardial infarction during percutaneous coronary intervention,which is associated with more severe myocardial injury and a worse prognosis.With the advancement of intracoronary physiology and imaging technology,the prevention and therapeutic interventions of CMD have attracted more attention.However,relevant guidelines or consensus on CMD are lacking in China.The current consensus summarizes the prevention and diagnostic strategies of emergency percutaneous coronary intervention-related CMD and gives suggestions to improve the prognosis of ST-segment elevation myocardial infarction patients based on evidence from recent clinical studies,guidelines,and consensus from international sources.展开更多
We construct a daily liquidity index of China’s government bond market using transaction data from the national interbank market during 2001–2020.The index is a composite of popular price-based and quantity-based me...We construct a daily liquidity index of China’s government bond market using transaction data from the national interbank market during 2001–2020.The index is a composite of popular price-based and quantity-based metrics of liquidity.The composite indices,ob-tained by averaging across different metrics and by applying the principal component analysis,respectively,both point to a better liquidity condition after 2010.Market liquidity swings appear to be highly correlated with domestic funding liquidity and financial mar-ket volatility,but display fewer correlations with global macrofinan-cial indicators.Our findings suggest that the further deepening of the government bond market would support domestic financial stability and monetary operations down the road.展开更多
In this paper, a coupled numerical groundwater and land subsidence model was developed for the Tianjin Plain. The model was employed to investigate the groundwater resources and their changes over the last decade, and...In this paper, a coupled numerical groundwater and land subsidence model was developed for the Tianjin Plain. The model was employed to investigate the groundwater resources and their changes over the last decade, and to further predict the changing patterns of the groundwater level and associated land subsidence in future. First, according to the regional hydrogeology, the simulation area was defined with an area of 10.6×103 km2, which was divided into six aquifer units. A coupled groundwater and land subsidence numerical model was built by using Modflow2005 and the land subsidence simulation module SUB(subsidence and aquifer-system compaction), in which the groundwater flow was modeled as three-dimensional unsteady flow and the land subsidence simulation was based on one-dimensional consolidation theory. The model was then calibrated by using the groundwater level contour lines, hydrographs, and land subsidence hydrographs over the period of 1998–2008. In addition, groundwater balance analysis of the simulation period indicated that under multi-year groundwater withdrawal condition the cross-flow recharge, compression release, and lateral boundary inflow contributed 44.43%, 32.14%, and 21.88% to the deep aquifer recharge, respectively. Finally, the model was applied to predict the changing patterns of the groundwater levels and the associated variations in land subsidence under the control of groundwater exploitation after implementation of the south-to-north water diversion project. The simulation results demonstrated that the groundwater level may gradually increase year by year with an decrease in the groundwater withdrawal; and the land in dominated land subsidence regions including the urban area, Dagang, Hangu, Jinghai, Wuqing, and Jinnan, may rebound at an average rate of 2–3 mm/a, and the land subsidence rate in the other regions may decrease.展开更多
Microfibrillated cellulose(MFC)-collagen composite films were prepared with a dispersion of acid swollen collagen fibers and carboxylated MFC at different ratios in an alkaline homogenous system.The surface topographi...Microfibrillated cellulose(MFC)-collagen composite films were prepared with a dispersion of acid swollen collagen fibers and carboxylated MFC at different ratios in an alkaline homogenous system.The surface topographic results obtained from SEM analyses indicated that the MFC entangled uniformly with collagen in the film and formed a closely interwoven network to reinforce the film structure.However,the MFC addition decreased the smoothness and light transparency of the films due to the aggregation of MFC.Compared to the film prepared with pure collagen,the hybrid composite film showed a higher strength and Young’s modulus but lower elongation.The swelling of the composite film in water increased with the increase of the MFC ratio in the film matrix.DSC and TG analyses demonstrated that adding MFC to collagen benefited the thermal stability of the films,due to the conformational and crystal changes in the MFC/collagen structure indicated by the FT-IR and XRD results.The MFC/collagen composite film can potentially be used as an edible material in the food and packaging industry,in particular for meat products.展开更多
Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular event.Early detection and precise intervention of VASP hold great clinical significance,yet remain a major challenge.Phot...Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular event.Early detection and precise intervention of VASP hold great clinical significance,yet remain a major challenge.Photodynamic therapy(PDT)realizes potent ablation efficacy under precise manipulation of laser irradiation.In this study,we constructed theranostic nanoprobes(NPs),which could precisely regress VASPs through a cascade of synergistic events triggered by local irradiation of lasers under the guidance of fluorescence/MR imaging.The NPs were formulated from human serum albumin(HSA)conjugated with a high affinity-peptide targeting osteopontin(OPN)and encapsulated with photosensitizer IR780 and hypoxia-activatable tirapazamine(TPZ).After intravenous injection into atherosclerotic mice,the OPN-targeted NPs demonstrated high specific accumulation in VASPs due to the overexpression of OPN in activated foamy macrophages in the carotid artery.Under the visible guidance of fluorescence and MR dual-model imaging,the precise near-infrared(NIR)laser irradiation generated massive reactive oxygen species(ROS),which resulted in efficient plaque ablation and amplified hypoxia within VASPs.In response to the elevated hypoxia,the initially inactive TPZ was successively boosted to present potent biological suppression of foamy macrophages.After therapeutic administration of the NPs for 2 weeks,the plaque area and the degree of carotid artery stenosis were markedly reduced.Furthermore,the formulated NPs displayed excellent biocompatibility.In conclusion,the developed HSA-based NPs demonstrated appreciable specific identification ability of VASPs and realized precise synergistic regression of atherosclerosis.展开更多
Objective:Older patients with comorbidity,such as coronary heart disease(CHD)and malignant gastrointestinal tumors,are at a high risk of bleeding events.However,risk prediction models based on risk factor assessment r...Objective:Older patients with comorbidity,such as coronary heart disease(CHD)and malignant gastrointestinal tumors,are at a high risk of bleeding events.However,risk prediction models based on risk factor assessment remain unclear.This study aimed to establish an individualized bleeding risk assessment system based on the analysis of 10-year inpatient clinical big data.Methods:Total clinical data of 56,819 patients with CHD and 25,988 patients with malignant digestive tract tumors(admitted from January 2008 to December 2017)were retrospectively collected at the First and Second Medical Centers of Chinese People's Liberation Army General Hospital.Among them,1307 patients with CHD and malignant digestive tract tumors were screened as the derivation cohort.The dependent variable was the occurrence of major clinical bleeding events.Baseline statistics and hypothesis tests of differences were performed for independent variables according to the occurrence of bleeding.Decision Tree,eXtreme Gradient Boosting(XGBoost),logistic regression,and random forest models were used for comparison.The accuracy,sensitivity,specificity,and area under the receiver operating characteristic curve(AUC-ROC)were applied as the criteria for evaluating and verifying model performance.To evaluate this developed model,another cohort comprising 454 patients(admitted from January 2018 to December 2019)was prospectively enrolled as the validation cohort based on the same inclusion and exclusion criteria.Results:Among the 64 variables with<50%missing values,the recursive feature elimination method with a random forest model was used to screen the selected variables.The highest accuracy was obtained following the selection of 10 scalars,and the final model was constructed accordingly.XGBoost demonstrated the best performance comprehensively.The AUC-ROC of this model was 0.981,with an accuracy,sensitivity,and specificity of 0.939,0.950,and 0.927,respectively.In the validation cohort,the AUC-ROC,accuracy,sensitivity,and specificity of the XGBoost model were 0.702,0.718,0.636,and 0.725,respectively.The rate of major bleeding events has a positive correlation with the bleeding risk score quintiles.To allow for convenient clinical application,a smartphone application was developed for easy access and calculation(http://fir.master-wx.com/sghr).Conclusion:We successfully established a risk model and score for predicting bleeding events in older patients with comorbidity,such as CHD and gastrointestinal cancer.展开更多
基金supported by the National Natural Science Foundation of China(21503100)Natural Science Foundation of Jiangxi Province(20161BAB213071,20151BAB213010)+1 种基金Project of Education Department of Jiangxi Province(GJJ150325)Sponsored Program for Cultivating Youths of Outstanding Ability in Jiangxi Normal University~~
基金supported by the National Key Research and Development Projects(2022YFC3602400)the National Natural Science Foundation of China(92249301 and U22A6008).
文摘Microcirculatory dysfunction(CMD)typically occurs in patients with acute ST-segment elevation myocardial infarction during percutaneous coronary intervention,which is associated with more severe myocardial injury and a worse prognosis.With the advancement of intracoronary physiology and imaging technology,the prevention and therapeutic interventions of CMD have attracted more attention.However,relevant guidelines or consensus on CMD are lacking in China.The current consensus summarizes the prevention and diagnostic strategies of emergency percutaneous coronary intervention-related CMD and gives suggestions to improve the prognosis of ST-segment elevation myocardial infarction patients based on evidence from recent clinical studies,guidelines,and consensus from international sources.
文摘We construct a daily liquidity index of China’s government bond market using transaction data from the national interbank market during 2001–2020.The index is a composite of popular price-based and quantity-based metrics of liquidity.The composite indices,ob-tained by averaging across different metrics and by applying the principal component analysis,respectively,both point to a better liquidity condition after 2010.Market liquidity swings appear to be highly correlated with domestic funding liquidity and financial mar-ket volatility,but display fewer correlations with global macrofinan-cial indicators.Our findings suggest that the further deepening of the government bond market would support domestic financial stability and monetary operations down the road.
基金supported by a grant from the National Basic Research Program of China (No. 2010CB428804)
文摘In this paper, a coupled numerical groundwater and land subsidence model was developed for the Tianjin Plain. The model was employed to investigate the groundwater resources and their changes over the last decade, and to further predict the changing patterns of the groundwater level and associated land subsidence in future. First, according to the regional hydrogeology, the simulation area was defined with an area of 10.6×103 km2, which was divided into six aquifer units. A coupled groundwater and land subsidence numerical model was built by using Modflow2005 and the land subsidence simulation module SUB(subsidence and aquifer-system compaction), in which the groundwater flow was modeled as three-dimensional unsteady flow and the land subsidence simulation was based on one-dimensional consolidation theory. The model was then calibrated by using the groundwater level contour lines, hydrographs, and land subsidence hydrographs over the period of 1998–2008. In addition, groundwater balance analysis of the simulation period indicated that under multi-year groundwater withdrawal condition the cross-flow recharge, compression release, and lateral boundary inflow contributed 44.43%, 32.14%, and 21.88% to the deep aquifer recharge, respectively. Finally, the model was applied to predict the changing patterns of the groundwater levels and the associated variations in land subsidence under the control of groundwater exploitation after implementation of the south-to-north water diversion project. The simulation results demonstrated that the groundwater level may gradually increase year by year with an decrease in the groundwater withdrawal; and the land in dominated land subsidence regions including the urban area, Dagang, Hangu, Jinghai, Wuqing, and Jinnan, may rebound at an average rate of 2–3 mm/a, and the land subsidence rate in the other regions may decrease.
基金The authors would like to acknowledge the financial support provided by,National High Technology Research and Development Program of China(No.2013AA102204)Special Fund for Agro-scientific Research in the Public Interest of China(No.201303082)。
文摘Microfibrillated cellulose(MFC)-collagen composite films were prepared with a dispersion of acid swollen collagen fibers and carboxylated MFC at different ratios in an alkaline homogenous system.The surface topographic results obtained from SEM analyses indicated that the MFC entangled uniformly with collagen in the film and formed a closely interwoven network to reinforce the film structure.However,the MFC addition decreased the smoothness and light transparency of the films due to the aggregation of MFC.Compared to the film prepared with pure collagen,the hybrid composite film showed a higher strength and Young’s modulus but lower elongation.The swelling of the composite film in water increased with the increase of the MFC ratio in the film matrix.DSC and TG analyses demonstrated that adding MFC to collagen benefited the thermal stability of the films,due to the conformational and crystal changes in the MFC/collagen structure indicated by the FT-IR and XRD results.The MFC/collagen composite film can potentially be used as an edible material in the food and packaging industry,in particular for meat products.
基金This work was supported by the National Nature Science Foundation of China(Nos.81820108019,91939303 and 31971302)the National Key Research and Development Program of China(2018YFC0116305)the Science Foundation of PLA General Hospital(2018XXFC-9,CX19028,China).
文摘Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular event.Early detection and precise intervention of VASP hold great clinical significance,yet remain a major challenge.Photodynamic therapy(PDT)realizes potent ablation efficacy under precise manipulation of laser irradiation.In this study,we constructed theranostic nanoprobes(NPs),which could precisely regress VASPs through a cascade of synergistic events triggered by local irradiation of lasers under the guidance of fluorescence/MR imaging.The NPs were formulated from human serum albumin(HSA)conjugated with a high affinity-peptide targeting osteopontin(OPN)and encapsulated with photosensitizer IR780 and hypoxia-activatable tirapazamine(TPZ).After intravenous injection into atherosclerotic mice,the OPN-targeted NPs demonstrated high specific accumulation in VASPs due to the overexpression of OPN in activated foamy macrophages in the carotid artery.Under the visible guidance of fluorescence and MR dual-model imaging,the precise near-infrared(NIR)laser irradiation generated massive reactive oxygen species(ROS),which resulted in efficient plaque ablation and amplified hypoxia within VASPs.In response to the elevated hypoxia,the initially inactive TPZ was successively boosted to present potent biological suppression of foamy macrophages.After therapeutic administration of the NPs for 2 weeks,the plaque area and the degree of carotid artery stenosis were markedly reduced.Furthermore,the formulated NPs displayed excellent biocompatibility.In conclusion,the developed HSA-based NPs demonstrated appreciable specific identification ability of VASPs and realized precise synergistic regression of atherosclerosis.
基金supported in part by research grants from the National Key Research and Development Program of China(2016YFA0100900)the International Cooperation and Exchange Program of National Science Foundation of China(81820108019)+2 种基金the National Natural Science Foundation of China(91939303,81820108019)Health care project(19BJZ25)the Talents Support Program of the China Postdoctoral Science Foundation(BX20200154).
文摘Objective:Older patients with comorbidity,such as coronary heart disease(CHD)and malignant gastrointestinal tumors,are at a high risk of bleeding events.However,risk prediction models based on risk factor assessment remain unclear.This study aimed to establish an individualized bleeding risk assessment system based on the analysis of 10-year inpatient clinical big data.Methods:Total clinical data of 56,819 patients with CHD and 25,988 patients with malignant digestive tract tumors(admitted from January 2008 to December 2017)were retrospectively collected at the First and Second Medical Centers of Chinese People's Liberation Army General Hospital.Among them,1307 patients with CHD and malignant digestive tract tumors were screened as the derivation cohort.The dependent variable was the occurrence of major clinical bleeding events.Baseline statistics and hypothesis tests of differences were performed for independent variables according to the occurrence of bleeding.Decision Tree,eXtreme Gradient Boosting(XGBoost),logistic regression,and random forest models were used for comparison.The accuracy,sensitivity,specificity,and area under the receiver operating characteristic curve(AUC-ROC)were applied as the criteria for evaluating and verifying model performance.To evaluate this developed model,another cohort comprising 454 patients(admitted from January 2018 to December 2019)was prospectively enrolled as the validation cohort based on the same inclusion and exclusion criteria.Results:Among the 64 variables with<50%missing values,the recursive feature elimination method with a random forest model was used to screen the selected variables.The highest accuracy was obtained following the selection of 10 scalars,and the final model was constructed accordingly.XGBoost demonstrated the best performance comprehensively.The AUC-ROC of this model was 0.981,with an accuracy,sensitivity,and specificity of 0.939,0.950,and 0.927,respectively.In the validation cohort,the AUC-ROC,accuracy,sensitivity,and specificity of the XGBoost model were 0.702,0.718,0.636,and 0.725,respectively.The rate of major bleeding events has a positive correlation with the bleeding risk score quintiles.To allow for convenient clinical application,a smartphone application was developed for easy access and calculation(http://fir.master-wx.com/sghr).Conclusion:We successfully established a risk model and score for predicting bleeding events in older patients with comorbidity,such as CHD and gastrointestinal cancer.