Seasonal variation of melatonin secretion across various segments of the gastrointestinal tract in rats

Objective To investigate whether melatonin(MT)secretion in different parts of the gastrointestinal tract(GIT)exhibits seasonal variations and its correlation with immune regulation.Methods Sixty Sprague-Dawley rats were divided into control and model groups,and the pineal gland was removed in the model group.Stomach,jejunum,ileum,and colon tissues were obtained during the spring equinox,summer solstice,beginning of autumn,autumn equinox,and winter solstice.The levels of MT,MT receptors(MR),arylalkylamine N-acetyltransferase(AANAT),hydroxyindole-O-methyltransferase(HIOMT),interleukin-2(IL-2),and interleukin-10(IL-10)in the GIT were measured using enzyme-linked immunosorbent assay.Results Except for the stomach,the jejunum,ileum,and the colon showed seasonal tendencies in MT secretion.In the control group,MT secretion in the jejunum and ileum was the highest in the long summer,and colonic MT secretion was the highest in winter.In the model group,MT levels in the colon were highest in the summer.The seasonal rhythms of the MR,AANAT,HIOMT,IL-2,and IL-10 in the colon were roughly similar to those of MT,and changed accordingly after pinealectomy.Conclusions Gastrointestinal MT secretion is related to seasonal changes,and MT secretion in each intestinal segment is influenced by different seasons.The biological effects of MT in the gut are inextricably linked to the mediation of MR,and a hormone-receptor linkage exists between MT and MR.The effect of seasonal changes on the gastrointestinal immune system may be mediated through the regulation of seasonal secretion of MT.

行为变异型额颞叶痴呆1例

目的:报道1例临床和影像学表现典型额颞叶痴呆病例。方法:对1例行为变异型额颞叶痴呆患者的临床和神经影像学表现进行分析。结果:本病例患者表现为社交行为异常,无相关疾病家族史。副肿瘤综合征及自身免疫性脑炎相关抗体阴性。头颅MRI显示双侧额颞叶及海马萎缩,右侧明显。头颅18F-FDG PET显示扣带回、双侧额颞叶FDG摄取明显减低。结论:神经影像学能反映FTD的病理学改变特征,提高对FTD及其亚型的诊断效能,在FTD诊断、治疗和随访等方面发挥重要作用。