Mechanical stimulation is the key physical factor in cell environment.Mechanotransduction acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specifi...Mechanical stimulation is the key physical factor in cell environment.Mechanotransduction acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specific signature alterations during the pathological process.As research continues,the role of epigenetic science in mechanotransduction is attracting attention.However,the molecular mechanism of the synergistic effect between mechanotransduction and epigenetics in physiological and pathological processes has not been clarified.We focus on how histone modifications,as important components of epigenetics,are coordinated with multiple signaling pathways to control cell fate and disease progression.Specifically,we propose that histone modifications can form regulatory feedback loops with signaling pathways,that is,histone modifications can not only serve as downstream regulators of signaling pathways for target gene transcription but also provide feedback to regulate signaling pathways.Mechanotransduction and epigenetic changes could be potential markers and therapeutic targets in clinical practice.展开更多
The unsatisfactory insulating properties of solid–gas interfaces seriously restrict the development of high-voltage electrical equipment and threaten their power supply sta-bility.Electron-beam irradiation(EBI)can ef...The unsatisfactory insulating properties of solid–gas interfaces seriously restrict the development of high-voltage electrical equipment and threaten their power supply sta-bility.Electron-beam irradiation(EBI)can effectively improve the surface flashover voltage of dielectrics.However,the underlying mechanism of EBI in tailoring the surface trap and improving the flashover voltage remains unclear.In this study,the surface morphologies and chemical compositions of epoxy composites treated with EBI were investigated.In addition,the surface wetting properties,surface charge migration pa-rameters,and surface flashover voltages were experimentally characterised.It was found that EBI aggravated the surface morphology,changed the surface chemical components,and repressed surface charge transportation.As a result,the contact angle was reduced from 103.7°to 78.43°,and the flashover voltage in SF6 was increased from 35.26 to 38.90 kV.DFT calculations showed that the newly generated C–O–H and C=O bonds on the surface molecules after EBI formed charge centres at the molecular electrostatic potential,which enhanced the trapping effect of the surface deep trap.As a result,surface charge migration was repressed,and the surface flashover voltage was improved.This study could promote the further development of EBI on materials modification.展开更多
基金the Department of Science and Technology of Jilin Province,China(No.20230101163JC and No.20210509003RQ)。
文摘Mechanical stimulation is the key physical factor in cell environment.Mechanotransduction acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specific signature alterations during the pathological process.As research continues,the role of epigenetic science in mechanotransduction is attracting attention.However,the molecular mechanism of the synergistic effect between mechanotransduction and epigenetics in physiological and pathological processes has not been clarified.We focus on how histone modifications,as important components of epigenetics,are coordinated with multiple signaling pathways to control cell fate and disease progression.Specifically,we propose that histone modifications can form regulatory feedback loops with signaling pathways,that is,histone modifications can not only serve as downstream regulators of signaling pathways for target gene transcription but also provide feedback to regulate signaling pathways.Mechanotransduction and epigenetic changes could be potential markers and therapeutic targets in clinical practice.
文摘The unsatisfactory insulating properties of solid–gas interfaces seriously restrict the development of high-voltage electrical equipment and threaten their power supply sta-bility.Electron-beam irradiation(EBI)can effectively improve the surface flashover voltage of dielectrics.However,the underlying mechanism of EBI in tailoring the surface trap and improving the flashover voltage remains unclear.In this study,the surface morphologies and chemical compositions of epoxy composites treated with EBI were investigated.In addition,the surface wetting properties,surface charge migration pa-rameters,and surface flashover voltages were experimentally characterised.It was found that EBI aggravated the surface morphology,changed the surface chemical components,and repressed surface charge transportation.As a result,the contact angle was reduced from 103.7°to 78.43°,and the flashover voltage in SF6 was increased from 35.26 to 38.90 kV.DFT calculations showed that the newly generated C–O–H and C=O bonds on the surface molecules after EBI formed charge centres at the molecular electrostatic potential,which enhanced the trapping effect of the surface deep trap.As a result,surface charge migration was repressed,and the surface flashover voltage was improved.This study could promote the further development of EBI on materials modification.
