Physical Activity,Sedentary Behavior,and the Risk of Cardiovascular Disease in Type 2 Diabetes Mellitus Patients:The MIDiab Study

The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity(MVPA)time and sedentary(SED)time with a history of cardiovascular disease(CVD)and multifactorial(i.e.,blood pressure(BP),body mass index(BMI),low-density lipoprotein cholesterol(LDL-C),and glycated hemoglobin A1c(HbA1c))control status among type 2 diabetes mellitus(T2DM)patients in China.A cross-sectional analysis of 9152 people with type 2 diabetes from the Multifactorial Intervention on Type 2 Diabetes(MIDiab)study was performed.Patients were grouped according to their self-reported MVPA time(low,<150 min·week−1;moderate,150 to<450 min·week−1;high,≥450 min·week−1)and SED time(low,<4 h·d–1;moderate,4 to<8 h·d–1;high,≥8 h·d–1).Participants who self-reported a history of CVD were identified as having a CVD risk.Odds ratios(ORs)and 95%confidence intervals(CIs)of CVD risk and multifactorial control status associated with MVPA time and SED time were estimated using mixed-effect logistic regression models,adjusting for China’s geographical region characteristics.The participants had a mean±standard deviation(SD)age of(60.87±8.44)years,44.5%were women,and 25.1%had CVD.After adjustment for potential confounding factors,an inverse association between high MVPA time and CVD risk that was independent of SED time was found,whereas this association was not observed in the moderate-MVPA group.A higher MVPA time was more likely to have a positive effect on the control of BMI.Compared with the reference group(i.e.,those with MVPA time≥450 min·week−1 and SED time<4 h·d–1),CVD risk was higher in the low-MVPA group:The OR associated with an SED time<4 h·d–1 was 1.270(95%CI,1.040–1.553)and that associated with an SED time≥8 h·d–1 was 1.499(95%CI,1.149–1.955).We found that a high MVPA time(i.e.,≥450 min·week−1)was associated with lower odds of CVD risk regardless of SED time among patients with T2DM.

膜龈手术中自体软组织替代物的研究进展

膜龈手术是多种矫正牙周软组织形态及结构异常的手术总称。传统膜龈手术中常使用带蒂或游离自体软组织移植治疗牙龈退缩和角化龈不足,但由于自体软组织移植瓣存在需要开辟第二术区、供区组织量有限和术后不适明显等不足,自体软组织替代材料的研究越来越受到关注。目前多种自体软组织替代材料已研发并应用于膜龈手术中,包括脱细胞真皮基质、异种胶原基质等。本文就现有几种软组织替代材料的特点和临床效果的研究进展做一综述,为临床膜龈手术中自体软组织替代物的应用提供参考。

Source and possible tectonic driver for Jurassic-Cretaceous gold deposits in the West Qinling Orogen, China

The West Qinling Orogen(WQO) in Central China Orogenic Belt contains numerous metasedimentary rock-hosted gold deposits(>2000 t Au), which mainly formed during two pulses: one previously recognized in the Late Triassic to Early Jurassic(T3 - J1) and one only recently identified in the Late Jurassic to Early Cretaceous(J3 - K1). Few studies have focused on the origin and geotectonic setting of the J3 - K1 gold deposits.Textural relationships, LA-ICP-MS trace element and sulfur isotope compositions of pyrites in hydrothermally altered T3 dykes within the J3 - K1 Daqiao deposit were used to constrain relative timing relationships between mineralization and pyrite growth in the dykes, and to characterize the source of ore fluid. These results are integrated with an overview of the regional geodynamic setting, to advance understanding of the tectonic driver for J3 - K1 hydrothermal gold systems. Pyrite in breccia-and dykehosted gold ores at Daqiao have similar chemical and isotopic compositions and are considered to be representative of J3 - K1 gold deposits in WQO. Co/Ni and sulfur isotope ratios suggest that ore fluids were derived from underlying Paleozoic Ni-and Se-rich carbonaceous sedimentary rocks. The geochemical data do not support the involvement of magmatic fluids. However, in the EQO(East Qinling Orogen), J3 - K1 deposits are genetically related to magmatism. Gold mineralization in WQO is contemporaneous with magmatic deposits in the EQO and both are mainly controlled by NE-and EWtrending structures produced by changes in plate motion of the Paleo-Pacific plate as it was subducted beneath the Eurasian continent. We therefore infer that the J3 - K1 structural regime facilitated the ascent of magma in the EQO and metamorphic fluids in the WQO with consequent differences in the character of contemporaneous ore deposits. If this is correct, then the far-field effects of subduction along the eastern margin of NE Asia extended 1000's of km into the continental interior.

Acidic Electrocatalytic Semihydrogenation of Alkynols to Alkenols on Copper Phosphide at Industrial-Level Current Density

Alkenols are important intermediates for the industrial manufacture of various commodities and fine chemicals.At present,alkenols are produced via thermocatalytic semihydrogenation of corresponding alkynols using precious metal Pd-based catalysts in pressurized hydrogen atmosphere.In this work,we highlight an efficient electrocatalytic strategy for selectively reducing alkynols to alkenols under ambient conditions.Using 2-methyl-3-butyn-2-ol as a model alkynol,Cu3P nanoarrays anchored on Cu foam remarkably deliver an industrial-level partial current density of 0.79 A·cm^(-2) and a specific selectivity of 98%for 2-methyl-3-buten-2-ol in acidic solution.Over a 40-runs stability test,Cu3P nanoarrays maintain 90%alkynol conversion and 90%alkenol selectivity.Even in a large two-electrode flow electrolyser,the single-pass alkynol conversion and alkenol selectivity of Cu3P nanoarrays exceed 90%.Moreover,this selective electrocatalytic hydrogenation approach is broadly feasible for the production of various water-soluble alkenols.Electrochemical analyses,theoretical simulation and electrochemical in-situ infrared investigations together reveal that exothermic alkynol hydrogenation,facile alkenol desorption and formation of active H on Cu3P surfaces account for the excellent electrocatalytic performance.

An Early Cretaceous gold mineralization event in the Triassic West Qinling orogen revealed from U-Pb titanite dating of the Ma'anqiao gold deposit

The West Qinling orogen in central China,formed from continental collision between the North China and Yangtze cratons in the Late Triassic,hosts numerous gold deposits with a total Au endowment of about 2000 t.Most deposits were emplaced at ca.250-195 Ma and are genetically associated with the Triassic orogenesis.Here in situ U-Pb titanite dating with laser ablation inductively coupled plasma mass spectrometry indicates the Ma’anqiao gold deposit in the northern portion of this orogen has a distinctive age and under a contrasting tectonic regime.This structurally controlled gold deposit is hosted in Late Ordovician to Early Silurian sub-greenschist facies metasedimentary rocks.The gold mineralization is hosted in quartz-pyritepyrrhotite veins and pyrite-pyrrhotite disseminations in hydrothermally altered rocks,which are crosscut by K-feldspar-calcitechlorite±pyrite veins.Titanite,present both in the disseminated sulfide ores and later veins,was used for in situ U-Pb dating.Titanite from three disseminated sulfide ore samples with Th and U averaging 27.46 and 39.31 ppm(1 ppm=1μg g^(-1)),respectively,yielded lower-intercept ages of 121.1±3.1 to 120.7±3.5 Ma(2σ)in the Tera-Wasserburg diagram.Titanite from three later vein samples with much lower Th and U concentrations averaging 2.74 and 16.21 ppm,respectively,yielded overlapping ages of 120.8±3.2 to 120.3±5.8 Ma(2σ).These new titanite U-Pb ages tightly constrain the formation of the Ma’anqiao gold deposit at ca.121-120 Ma and,when combined with independent geological data,indicate it is not related to the Triassic Qinling orogeny.Rather,its formation is attributed to lithospheric thinning and destruction of the North China craton during the Late Jurassic to Early Cretaceous which has generated numerous gold deposits along the southern margin of this craton.This catastrophic event caused extensive magmatism in large areas of the North Qinling terrane and northern edge of the West Qinling orogen immediately to the south of the North China craton.The heat flux and elevated geothermal gradients associated with this magmatism could have induced prograde metamorphism of the Paleozoic sedimentary infrastructure in and beneath these areas with the derived fluids ascending along pre-existing crustal-scale regional structures to form the Ma’anqiao gold deposit.We suggest that areas in the North Qinling terrane that have been affected by the Late Mesozoic magmatism are potential targets for future exploration of the decratonization-related gold deposits.Additionally,this study highlights the use of titanite U-Pb dating as a robust geochronometer for metasedimentary rock-hosted gold deposits in Phanerozoic orogens,which has previously not been utilized.