Importance:Central line-associated bloodstream infection(CLABSI)is one of the most serious complications of central venous access devices.Reducing the risk of CLABSI is of utmost significance in efforts to improve neo...Importance:Central line-associated bloodstream infection(CLABSI)is one of the most serious complications of central venous access devices.Reducing the risk of CLABSI is of utmost significance in efforts to improve neonatal mortality rates and enhance long-term prognosis.Objective:To determine the dwell time and incidence of CLABSI of umbilical venous catheterization(UVC)for preterm infants in China.Methods:Preterm infants with UVC admitted to 44 tertiary neonatal intensive care units in 24 provinces in China were enrolled.Study period was from November 2019 to August 2021.The end point of observations was 48 h after umbilical venous(UV)catheter removal.The primary outcomes were dwell time of UV catheter and UVC-associated CLABSI.Data between infants with UV catheter dwell time≤7 days and>7 days,and with birth weight(BW)≤1000 g and>1000 g were compared.Results:In total,2172 neonates were enrolled(gestational age 30.0±2.4 weeks,BW 1258.5±392.8 g).The median UV catheter dwell time was 7(6–10)days.The incidence of UVC-associated CLABSI was 3.03/1000 UV catheter days.For infants with UV catheter dwell time≤7 days and>7 days,the UVC-associated CLABSI incidence was 3.71 and 2.65 per 1000 UV catheter days,respectively,P=0.23.For infants with UVC dwell times of 3–6,7–12,and 13–15 days,the UVC-associated CLABSI rates were 0.14%,0.68%,and 2.48%(P<0.01).The Kaplan–Meier plot of UV catheter dwell time to CLABSI showed no difference between infants with BW≤1000 g and>1000 g(P=0.60).Interpretation:The median dwell time of UV catheter was 7 days,and the incidence of UVC-associated CLABSI was 3.03/1000 catheter days in China.The daily risk of UVC-associated CLABSI and other complications increased with the dwell time.展开更多
To the Editor:Although reports of neonatal upper airway obstruction in patients in neonatal intensive care units(NICUs)are common,neonatal tracheotomy is rare,possibly due to the small number of patients and the even ...To the Editor:Although reports of neonatal upper airway obstruction in patients in neonatal intensive care units(NICUs)are common,neonatal tracheotomy is rare,possibly due to the small number of patients and the even smaller number of well-equipped hospitals to do a successful operation in neonates.However,despite the extensive efforts of qualified,skilled neonatologists and pediatric otorhinolaryngologists in performing a neonatal tracheotomy,some neonates did not undergo this surgery.When a neonate meets the indications of tracheotomy but his/her parent refuses to do the operation,he/she is facing a higher risk to be discharged against medical advice(DAMA)as per their parents’wish.To explore the preliminary evidence of neonatal tracheotomy in China,as well as to find out the outcome difference between neonates who underwent tracheotomy and those who did not undergo tracheotomy when they met the surgical indications,we conducted a retrospective study.Patients were treated in Beijing Children’s Hospital.Patients were categorized into the tracheotomy group or non-tracheotomy group according to whether their parents signed the tracheotomy consent and finally completed the tracheotomy.This study was approved by the Ethics Committee of Beijing Children’s Hospital,Capital Medical University(No.[2021]-E-139-R)and was registered in the Chinese Clinical Trial Registry(No.ChiCTR2100050720).All parents/guardians of participants provided written informed consent.展开更多
There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE...There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency.展开更多
In this work, a new porous Zrobased metal-organic framework （MOF） with a large Brunner-Emmet-Teller （BET） surface area was prepared by the solvothermal method using 4,4＇-（naphthalene-1,4-diyl）dibenzoic acid （N...In this work, a new porous Zrobased metal-organic framework （MOF） with a large Brunner-Emmet-Teller （BET） surface area was prepared by the solvothermal method using 4,4＇-（naphthalene-1,4-diyl）dibenzoic acid （NDDA） as the organic ligand, and the luminescent detection performance was studied systematically. The experiments comb- ing with computations indicate that the as-synthesized material can sensitively and selectively detect nitro explo- sives and metal ions, especially for 2,4,6-trinitrophenol （TNP） and Fe3＋, due to the possible electron transfer from inorganic moieties to organic moieties with naphthalene part. Interestingly, owing to its high porosity and large sur- face area, this Zr-MOF showed quick luminescent response time （in 1 min） for TNP and Fe3＋. The results obtained may provide useful information for the design of MOFs with the large permanent porosity in sensing applications for large molecules in the future.展开更多
Importance:A web-based instrument for self-assessment of puberty could be convenient and feasible for large-scale multicenter populationbased epidemiological studies for Tanner stages evaluation.Objective:To validate ...Importance:A web-based instrument for self-assessment of puberty could be convenient and feasible for large-scale multicenter populationbased epidemiological studies for Tanner stages evaluation.Objective:To validate web-based self-assessment of pubertal development against assessment by a pediatrician.Methods:Outpatients aged 8-18 years were consecutively recruited in the endocrinology department of Beijing Children's Hospital from October 2016 to August 2017.A web-based self-assessment instrument for pubertal development was introduced to participants by an appointed pediatrician.Tanner stage of puberty was self-assessed by participants in a private environment.Participants were then examined by a senior pediatrician underwent blinded assessment.Weighted kappa and Spearman correlation analyses were conducted to evaluate agreement.The accuracy of the web-based instrument for self-assessment of pubertal onset was evaluated according to sensitivity,specificity,positive predictive value and negative predictive value.Results:A total of 174 participants (including 82 girls and 92 boys)were assessed consecutively.Correlation coefficients were 0.872 for pubic hair and 0.933 for testicular volume (P<0.001) among boys;a similar result was obtained for the weighted kappa value (0.825).For girls,the correlation coefficient and weighted kappa for pubic hair was 0.785 and 0.878,respectively.However,breast self-assessment had a medium level of agreement with pediatrician assessment (weighted kappa,0.495;correlation coefficient,0.643).Moreover,the accuracy of self-assessment in children aged 10 years or above was better than that in children aged less than 10 years.Interpretation:Assessment of pubertal development using a webbased self-assessment instrument could be less accurate among children aged less than 10 years,especially for girls' breast assessment.Therefore,self-assessment of pubertal development,especially for breast development,should be interpreted cautiously.展开更多
基金supported by the National Natural Science Foundation of China(22273108,22073104,22293015,22033009,21890761,22121002,and 12275300)Beijing Natural Science Foundation(2222043)+1 种基金Chinese Academy of Sciences(CAS)Project for Young Scientists in Basic Research(YSBR-050)the Innovation Program of the Institute of High Energy Physics,CAS(2023000034)。
基金Capital’s Funds for Health Improvement and Research,Grant/Award Number:2022-2-2095。
文摘Importance:Central line-associated bloodstream infection(CLABSI)is one of the most serious complications of central venous access devices.Reducing the risk of CLABSI is of utmost significance in efforts to improve neonatal mortality rates and enhance long-term prognosis.Objective:To determine the dwell time and incidence of CLABSI of umbilical venous catheterization(UVC)for preterm infants in China.Methods:Preterm infants with UVC admitted to 44 tertiary neonatal intensive care units in 24 provinces in China were enrolled.Study period was from November 2019 to August 2021.The end point of observations was 48 h after umbilical venous(UV)catheter removal.The primary outcomes were dwell time of UV catheter and UVC-associated CLABSI.Data between infants with UV catheter dwell time≤7 days and>7 days,and with birth weight(BW)≤1000 g and>1000 g were compared.Results:In total,2172 neonates were enrolled(gestational age 30.0±2.4 weeks,BW 1258.5±392.8 g).The median UV catheter dwell time was 7(6–10)days.The incidence of UVC-associated CLABSI was 3.03/1000 UV catheter days.For infants with UV catheter dwell time≤7 days and>7 days,the UVC-associated CLABSI incidence was 3.71 and 2.65 per 1000 UV catheter days,respectively,P=0.23.For infants with UVC dwell times of 3–6,7–12,and 13–15 days,the UVC-associated CLABSI rates were 0.14%,0.68%,and 2.48%(P<0.01).The Kaplan–Meier plot of UV catheter dwell time to CLABSI showed no difference between infants with BW≤1000 g and>1000 g(P=0.60).Interpretation:The median dwell time of UV catheter was 7 days,and the incidence of UVC-associated CLABSI was 3.03/1000 catheter days in China.The daily risk of UVC-associated CLABSI and other complications increased with the dwell time.
基金Capital’s Funds for Health Improvement and Research(No.2022-2-2096)
文摘To the Editor:Although reports of neonatal upper airway obstruction in patients in neonatal intensive care units(NICUs)are common,neonatal tracheotomy is rare,possibly due to the small number of patients and the even smaller number of well-equipped hospitals to do a successful operation in neonates.However,despite the extensive efforts of qualified,skilled neonatologists and pediatric otorhinolaryngologists in performing a neonatal tracheotomy,some neonates did not undergo this surgery.When a neonate meets the indications of tracheotomy but his/her parent refuses to do the operation,he/she is facing a higher risk to be discharged against medical advice(DAMA)as per their parents’wish.To explore the preliminary evidence of neonatal tracheotomy in China,as well as to find out the outcome difference between neonates who underwent tracheotomy and those who did not undergo tracheotomy when they met the surgical indications,we conducted a retrospective study.Patients were treated in Beijing Children’s Hospital.Patients were categorized into the tracheotomy group or non-tracheotomy group according to whether their parents signed the tracheotomy consent and finally completed the tracheotomy.This study was approved by the Ethics Committee of Beijing Children’s Hospital,Capital Medical University(No.[2021]-E-139-R)and was registered in the Chinese Clinical Trial Registry(No.ChiCTR2100050720).All parents/guardians of participants provided written informed consent.
基金supported by the Medical Hospital Authority of the National Health Commission of China
文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency.
基金Financial support by the National Key Basic Re- search Programof China （＂973＂） （No. 2013CB733503）, the National Natural Science Foundation of China （Nos. 21606007, 21136001 and 21536001） and the Funda- mental Research Funds for the Central Universities （No. ZY1509） is greatly appreciated.
文摘In this work, a new porous Zrobased metal-organic framework （MOF） with a large Brunner-Emmet-Teller （BET） surface area was prepared by the solvothermal method using 4,4＇-（naphthalene-1,4-diyl）dibenzoic acid （NDDA） as the organic ligand, and the luminescent detection performance was studied systematically. The experiments comb- ing with computations indicate that the as-synthesized material can sensitively and selectively detect nitro explo- sives and metal ions, especially for 2,4,6-trinitrophenol （TNP） and Fe3＋, due to the possible electron transfer from inorganic moieties to organic moieties with naphthalene part. Interestingly, owing to its high porosity and large sur- face area, this Zr-MOF showed quick luminescent response time （in 1 min） for TNP and Fe3＋. The results obtained may provide useful information for the design of MOFs with the large permanent porosity in sensing applications for large molecules in the future.
文摘Importance:A web-based instrument for self-assessment of puberty could be convenient and feasible for large-scale multicenter populationbased epidemiological studies for Tanner stages evaluation.Objective:To validate web-based self-assessment of pubertal development against assessment by a pediatrician.Methods:Outpatients aged 8-18 years were consecutively recruited in the endocrinology department of Beijing Children's Hospital from October 2016 to August 2017.A web-based self-assessment instrument for pubertal development was introduced to participants by an appointed pediatrician.Tanner stage of puberty was self-assessed by participants in a private environment.Participants were then examined by a senior pediatrician underwent blinded assessment.Weighted kappa and Spearman correlation analyses were conducted to evaluate agreement.The accuracy of the web-based instrument for self-assessment of pubertal onset was evaluated according to sensitivity,specificity,positive predictive value and negative predictive value.Results:A total of 174 participants (including 82 girls and 92 boys)were assessed consecutively.Correlation coefficients were 0.872 for pubic hair and 0.933 for testicular volume (P<0.001) among boys;a similar result was obtained for the weighted kappa value (0.825).For girls,the correlation coefficient and weighted kappa for pubic hair was 0.785 and 0.878,respectively.However,breast self-assessment had a medium level of agreement with pediatrician assessment (weighted kappa,0.495;correlation coefficient,0.643).Moreover,the accuracy of self-assessment in children aged 10 years or above was better than that in children aged less than 10 years.Interpretation:Assessment of pubertal development using a webbased self-assessment instrument could be less accurate among children aged less than 10 years,especially for girls' breast assessment.Therefore,self-assessment of pubertal development,especially for breast development,should be interpreted cautiously.
