Fe2Ga2S5 as a 2D Antiferromagnetic Semiconductor

We theoretically investigate physical properties of two-dimensional(2D)Fe2Ga2S5 by employing first-principles calculations.It is found that it is an antiferromagnet with zigzag magnetic configuration orienting in the in-plane direction,with Néel temperatures around 160 K.The band structure of the ground state shows that it is a semiconductor with the indirect band gap of about 0.9 eV,which could be effectively tuned by the lattice strain.We predict that the carrier transport is highly anisotropic,with the electron mobility up to the order of∼103 cm 2/(V⋅s)much higher than the hole.These fantastic electronic properties make 2D Fe2Ga2S5 a promising candidate for the future spintronics.

Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair

The repair of infective bone defects is a great challenge in clinical work.It is of vital importance to develop a kind of bone scaffold with good osteogenic properties and long-term antibacterial activity for local anti-infection and bone regeneration.A porous mineralized collagen(MC)scaffold containing poly(D,L-lactide-co-glycolic acid)(PLGA)microspheres loaded with two antibacterial synthetic peptides,Pac-525 or KSL-W was developed and characterized via scanning electron microscopy(SEM),porosity measurement,swelling and mechanical tests.The results showed that the MC scaffold embedded with smooth and compact PLGA microspheres had a positive effect on cell growth and also had antibacterial properties.Through toxicity analysis,cell morphology and proliferation analysis and alkaline phosphatase evaluation,the antibacterial scaffolds showed excellent biocompatibility and osteogenic activity.The antibacterial property evaluated with Staphylococcus aureus and Escherichia coli suggested that the sustained release of Pac-525 or KSL-W from the scaffolds could inhibit the bacterial growth aforementioned in the long term.Our results suggest that the antimicrobial peptides-loaded MC bone scaffold has good antibacterial and osteogenic activities,thus providing a great promise for the treatment of infective bone defects.