Case Study on Critical Success Factors of Running Scrum

Agile development 12 principles, and adaptive project management life cycle model are applied to case study of J group, the critical success factors of running Scrum are identified as follows: 1) explicit the process of project management and a self-managing group with Scrum;2) professional agile development and release capability;3) building learning organization. J group as a pioneer Scrum agile software development practices, realizes the productivity of significant promotion and cost reduction, accelerates the product to the market, improves customer satisfaction and achieves a more transparent development process and higher predictive capability. The study aims to improve the success rate of the running Scrum.

Compact input-reflectionless balanced bandpass filter with flexible bandwidth using three-line coupled structure

A compact input-reflectionless balanced bandpass filter(BPF)with flexible bandwidth(BW)using a three-line coupled structure(TLCS)is presented in this paper.For the differential mode(DM),the TLCS is applied to achieve the bandpass response;meanwhile,the input coupled-feed line of the TLCS is reused in the input absorption network.This design shows a good fusion of the absorptive and BPF sections,effectively reducing the circuit size,and the BWs of the two sections that can be controlled separately result in a flexibly controllable DM response BW of the proposed input-reflectionless balanced BPF.Detailed analyses of the ratio of the two-part BWs have been given for the first time,which is vital for the passband flatness and reflectionless feature.In the codesign of this work,the input-reflectionless DM bandpass response can be optimized easily,while wideband common mode(CM)noise absorption is achieved by the input absorption network.To verify the design method,a prototype with a compact layout(0.52λ×0.36λ)is designed and measured in the 0-7.0 GHz range.The DM center frequency(f0)is 2.45 GHz with a measured 3 dB fractional bandwidth of 31.4%.The simulation and measurement results with good agreement are presented,showing good performance,e.g.,low insertion loss(0.43 dB),wide upper stopband for the DM bandpass response(over 20 dB rejection level up to 2.72f0),and wideband DM reflectionless and CM noise absorption(fractional absorption bandwidth of 285.7%).

First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

Metastatic pancreatic cancer(mPC)has a dismal prognosis.Herein,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and safety.In 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,respectively.Grade 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer PFS.Additionally,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable efficacy.In conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for mPC.The biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.