Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic diseases.However,how these practices affect immune function is not w...Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic diseases.However,how these practices affect immune function is not well understood.In a recent study published in Immunity,Janssen et al.delve into the complex relationship among fasting,refeeding,and the immune system.While fasting caused monocyte homing in bone marrow(BM),refeeding escalated monocyte counts in the circulation but altered immune responses to bacterial infection[1].展开更多
A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions atten...A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic strategy.Atherosclerosis continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or stroke.The disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood pressure.Beyond such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.展开更多
基金supported by The Netherlands Organization for Scientific Research(VENI grant 09150161910024).YS would like to acknowledge the European network for converting molecular profiles of myeloid cells into biomarkers for inflammation and cancer(Mye-InfoBank)(COST Action CA20117)Dr.Robert Pfleger Foundation(grant ZUW80298).The Open Access Publication was supported by the University of Münster.
文摘Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic diseases.However,how these practices affect immune function is not well understood.In a recent study published in Immunity,Janssen et al.delve into the complex relationship among fasting,refeeding,and the immune system.While fasting caused monocyte homing in bone marrow(BM),refeeding escalated monocyte counts in the circulation but altered immune responses to bacterial infection[1].
基金Open Access funding enabled and organized by Projekt DEALY.S.would like to acknowledge European network for research in vascular ageing(COST Action 18216)+2 种基金Dr.Robert Pfleger Foundation(grant ZUW80298)O.S.receives support from the Deutsche Forschungsgemeinschaft(SFB914 B8,SFB1009 A13,SFB1123 A6,SFB/TRR332 A2&Z1,OR465/1-1)the Else Kröner Fresenius Stiftung,the Leducq Foundation and the IZKF of the Medical Faculty of the University of Münster.
文摘A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic strategy.Atherosclerosis continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or stroke.The disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood pressure.Beyond such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.
