Inversion of surface vegetation water content based on GNSS-IR and MODIS data fusion

Obtaining high-precision,long-term sequences of vegetation water content(VWC)is of great significance for assessing surface vegetation growth,soil moisture,and fire risk.In recent years,the global navigation satellite system-interferometric reflection(GNSS-IR)has become a new type of remote sensing technology with low cost,all-weather capability,and a high temporal resolution.It has been widely used in the fields of snow depth,sea level,soil moisture content,and vegetation water content.The normalized microwave reflectance index(NMRI)based on GNSS-IR technology has been proven to be effective in monitoring changes in VWC.This paper considers the advantages and disadvantages of remote sensing technology and GNSS-IR technology in estimating VWC.A point-surface fusion method of GNSS-IR and MODIS data based on the GA-BP neural network is proposed to improve the accuracy of VWC estimation.The vegetation index products(NDVI,GPP,LAI)and the NMRI that unified the temporal and spatial resolution were used as the input and output data of the training model,and the GA-BP neural network was used for training and modeling.Finally,a spatially continuous NMRI product was generated.Taking a particular area of the United States as a research object,experiments show that(1)a neural network can realize the effective fusion of GNSS-IR and MODIS products.By comparing the GA-BP neural network,BP neural network,and multiple linear regression(MLR),the three models fusion effect.The results show that the GA-BP neural network has the best modeling effect,and the r and RMSE between the model estimation result and the reference value are 0.778 and 0.0332,respectively;this network is followed by the BP neural network,in which the r and RMSE are 0.746 and 0.0465,respectively.MLR has the poorest effect,with r and RMSE values of 0.500 and 0.0516,respectively.(2)The spatiotem-poral variation in the 16 days/500 m resolution NMRI product obtained by GA-BP neural network fusion is consistent with that in the experimental area.Through the testing of GNSS stations that did not participate in the modeling,the r between the estimated value of the NMRI and the reference value is greater than 0.87,and the RMSE is less than 0.049.Therefore,the method proposed in this paper is optional and effective.The spatially continuous NMRI products obtained by fusion can reflect the changes in VWC in the experimental area more intuitively.

Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain

Soluble epoxide hydrolase(sEH) is related to arachidonic acid cascade and is over-expressed in a variety of diseases, making sEH an attractive target for the treatment of pain as well as inflammatory-related diseases. A new series of memantyl urea derivatives as potent sEH inhibitors was obtained using our previous reported compound 4 as lead compound. A preferential modification of piperidinyl to 3-carbamoyl piperidinyl was identified for this series via structure-based rational drug design. Compound A20 exhibited moderate percentage plasma protein binding(88.6%) and better metabolic stability in vitro. After oral administration, the bioavailability of A20 was 28.6%. Acute toxicity test showed that A20 was well tolerated and there was no adverse event encountered at dose of 6.0 g/kg. Inhibitor A20 also displayed robust analgesic effect in vivo and dose-dependently attenuated neuropathic pain in rat model induced by spared nerve injury, which was better than gabapentin and sEH inhibitor(±)-EC-5026. In one word, the oral administration of A20 significantly alleviated pain and improved the health status of the rats, demonstrating that A20 was a promising candidate to be further evaluated for the treatment of neuropathic pain.