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基于老年营养风险指数构建老年非小细胞肺癌患者的预后模型 被引量:4
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作者 张晓楠 熊雅俊 许爱国 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第7期497-506,共10页
背景与目的癌症患者的营养状况与预后之间的关系已成为研究关注的热点。本研究旨在探索老年营养风险指数(geriatric nutritional risk index,GNRI)在老年非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后评估中的应用价值,构建... 背景与目的癌症患者的营养状况与预后之间的关系已成为研究关注的热点。本研究旨在探索老年营养风险指数(geriatric nutritional risk index,GNRI)在老年非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后评估中的应用价值,构建预测老年NSCLC患者预后的列线图模型。方法回顾性分析郑州大学第一附属医院于2016年1月至2019年12月初治的、≥65岁的153例NSCLC患者的资料。使用受试者工作特征(receiver operating characteristic,ROC)曲线确定GNRI的最佳截断值,把患者分为高GNRI组和低GNRI组,通过Kaplan-Meier曲线和Log-rank检验对两组患者总生存期(overall survival,OS)进行比较。使用单因素和多因素Cox回归分析探讨老年NSCLC患者不良预后的危险因素,利用R软件构建预测老年NSCLC患者生存率的列线图模型,并验证该模型。结果高GNRI组和低GNRI组在年龄、性别、体重指数(body mass index,BMI)、组织学类型、白蛋白水平、治疗方式、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、预后营养指数(prognostic nutritional index,PNI)、全身免疫炎症指数(systemic immuneinflammation index,SII)和细胞角蛋白19片段(cytokeratin 19 fragment,CYFRA21-1)方面存在统计学差异(P<0.05)。Kaplan-Meier曲线显示低GNRI组的患者总生存期较短。多因素Cox回归分析显示CYFRA21-1>3.3 ng/mL是影响NSCLC患者OS的独立危险因素,GNRI>97.09是保护因素[风险比(hazard ratio,HR)=0.52,95%置信区间(confidence interval,CI):0.34-0.79,P<0.05]。Ⅳ期患者发生死亡的风险是I期患者的1.98倍(95%CI:1.02-3.86,P<0.05)。与行综合治疗的患者相比,行单一化疗的患者发生死亡的风险增加3.58倍(95%CI:2.03-6.32,P<0.05)。基于GNRI构建的列线图模型对老年NSCLC患者OS进行预测,其一致性指数(concordance index,C-index)为0.70(95%CI:0.65-0.76),预测1、2年生存率的曲线下面积(area under the curve,AUC)分别为0.93(95%CI:0.87-0.98)、0.72(95%CI:0.63-0.80),校准曲线显示该模型的预测符合度较好。结论高GNRI评分与改善老年NSCLC患者的生存率显著相关,依靠截断值可能提供恰当的营养支持时机。该研究构建的列线图可作为一种有效预测老年NSCLC患者生存率的工具,具有很强的临床实用性。 展开更多
关键词 老年营养风险指数 老年 肺肿瘤 总体生存率 营养状况
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SPP-extractor:Automatic phenotype extraction for densely grown soybean plants 被引量:1
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作者 Wan Zhou Yijie Chen +6 位作者 Weihao Li Cong Zhang yajun xiong Wei Zhan Lan Huang Jun Wang Lijuan Qiu 《The Crop Journal》 SCIE CSCD 2023年第5期1569-1578,共10页
Automatic collecting of phenotypic information from plants has become a trend in breeding and smart agriculture.Targeting mature soybean plants at the harvesting stage,which are dense and overlapping,we have proposed ... Automatic collecting of phenotypic information from plants has become a trend in breeding and smart agriculture.Targeting mature soybean plants at the harvesting stage,which are dense and overlapping,we have proposed the SPP-extractor(soybean plant phenotype extractor)algorithm to acquire phenotypic traits.First,to address the mutual occultation of pods,we augmented the standard YOLOv5s model for target detection with an additional attention mechanism.The resulting model could accurately identify pods and stems and could count the entire pod set of a plant in a single scan.Second,considering that mature branches are usually bent and covered with pods,we designed a branch recognition and measurement module combining image processing,target detection,semantic segmentation,and heuristic search.Experimental results on real plants showed that SPP-extractor achieved respective R^(2) scores of 0.93–0.99 for four phenotypic traits,based on regression on manual measurements. 展开更多
关键词 Soybean phenotype Branch length Computer vision A*algorithm Phenotype acquisition
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Genetic dissection of and genomic selection for seed weight, pod length,and pod width in soybean
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作者 Yijie Chen yajun xiong +9 位作者 Huilong Hong Gang Li Jie Gao Qingyuan Guo Rujian Sun Honglei Ren Fan Zhang Jun Wang Jian Song Lijuan Qiu 《The Crop Journal》 SCIE CSCD 2023年第3期832-841,共10页
A biparental soybean population of 364 recombinant inbred lines(RILs)derived from Zhongdou 41×ZYD02.878 was used to identify quantitative trait loci(QTL)associated with hundred-seed weight(100-SW),pod length(PL),... A biparental soybean population of 364 recombinant inbred lines(RILs)derived from Zhongdou 41×ZYD02.878 was used to identify quantitative trait loci(QTL)associated with hundred-seed weight(100-SW),pod length(PL),and pod width(PW).100-SW,PL,and PW showed moderate correlations among one another,and 100-SW was correlated most strongly with PW(0.64–0.74).Respectively 74,70,75 and19 QTL accounting for 38.7%–78.8%of total phenotypic variance were identified by inclusive composite interval mapping,restricted two-stage multi-locus genome-wide association analysis,3 variancecomponent multi-locus random-SNP-effect mixed linear model analysis,and conditional genome-wide association analysis.Of these QTL,189 were novel,and 24 were detected by multiple methods.Six loci were associated with 100-SW,PL,and PW and may be pleiotropic loci.A total of 284 candidate genes were identified in colocalizing QTL regions,including the verified gene Seed thickness 1(ST1).Eleven genes with functions involved in pectin biosynthesis,phytohormone,ubiquitin-protein,and photosynthesis pathways were prioritized by examining single nucleotide polymorphism(SNP)variation,calculating genetic differentiation index,and inquiring gene expression.The prediction accuracies of genomic selection(GS)for 100-SW,PL,and PW based on single trait-associated markers reached 0.82,0.76,and 0.86 respectively,but selection index(SI)-assisted GS strategy did not increase GS efficiency and inclusion of trait-associated markers as fixed effects reduced prediction accuracy.These results shed light on the genetic basis of 100-SW,PL,and PW and provide GS models for these traits with potential application in breeding programs. 展开更多
关键词 SOYBEAN Seed weight Pod size Genetic analysis Genomic selection
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Influence of circulation types on temporal and spatial variations of ozone in Beijing 被引量:1
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作者 Xiaowan Zhu JinWu +8 位作者 Guiqian Tang Lin Qiao Tingting Han Xiaomei Yin Xiangxue Liu Ziming Li yajun xiong Di He Zhiqiang Ma 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2023年第8期37-51,共15页
This study analyzes the impact of circulation types(CTs)on ozone(O_(3))pollution in Beijing.The easterly high-pressure(SWW)circulation occurred most frequently(30%;276 day),followed by northwesterly high-pressure(AN)c... This study analyzes the impact of circulation types(CTs)on ozone(O_(3))pollution in Beijing.The easterly high-pressure(SWW)circulation occurred most frequently(30%;276 day),followed by northwesterly high-pressure(AN)circulation(24.3%;224 day).The SWW type had the highest O_(3) anomaly of+17.28μg/m^(3),which was caused by excellent photochemical reactions,poor diffusion ability and regional transport.Due to the higher humidity and precipitation in the low-pressure type(C),the O_(3) increase(+8.02μg/m^(3))was less than that in the SWW type.Good diffusion/wet deposition and weak formation ability contributed to O_(3) decrease in AN(-12.54μg/m^(3))and northerly high-pressure(ESN)CTs(-12.26μg/m^(3)).The intra-area transport of O_(3) was significant in polluted circulations(SWW-and C-CTs).In addition,higher temperature,radiation and less rainfall also contributed to higher O_(3) in northern Beijing under the SWW type.For the clean CTs(AN and ESN CTs),precursor amount and intra-area transport played a dominant role in O_(3) distribution.Under the northeasterly low-pressure CT,better formation conditions and higher precursor amount combined with the intra-area southerly transport to cause higher O_(3) values in the south than in the north.The higher O_(3) in the northwestern area under the northeasterly high-pressure type was influenced by weaker titration loss and high O_(3) concentration in previous day.Annual variation in the CTs contributed up to 86.1%of the annual variation in O_(3).About 78%-83%of the diurnal variation in O_(3) resulted from local meteorological factors. 展开更多
关键词 OZONE Objective synoptic classification Temporal variation and spatial distribution Intra-area transport
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Simulation and Projection of Near-Surface Wind Speeds in China by BCC-CSM Models 被引量:1
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作者 yajun xiong Xiaoge XIN Xingxia KOU 《Journal of Meteorological Research》 SCIE CSCD 2019年第1期149-158,共10页
We evaluated the ability of the Beijing Climate Center models on different horizontal resolutions(BCC-CSM1.1 on approximately 280-km resolution and BCC-CSM1.1 m on approximately 110-km resolution) in simulating the ne... We evaluated the ability of the Beijing Climate Center models on different horizontal resolutions(BCC-CSM1.1 on approximately 280-km resolution and BCC-CSM1.1 m on approximately 110-km resolution) in simulating the nearsurface wind speeds(NWS) in China during 1961–2005. The spatial distribution of the annual mean NWS over China is better captured by BCC-CSM1.1 m than by BCC-CSM1.1 due to the finer resolution. The weakened NWS over China during 1961–2005 cannot be reproduced by BCC-CSM1.1, whereas BCC-CSM1.1 m is able to simulate the decreasing trend of the autumn NWS in North China, although the magnitude is about 1/3 of the observed value.This is attributed to the better performance of this finer-resolution model in reproducing the increase in sea level pressure over Mongolia and North China over the past 45 years. The results suggest that increasing the horizontal resolution of the BCC-CSM model has improved its ability in reproducing the spatial distribution and long-term changes of NWS over China. Future projections by BCC-CSM1.1 m under different Representative Concentration Pathway(RCP) scenarios demonstrate that the autumn NWS in North China will decrease during the 21 st century under both the middle(RCP4.5) and high(RCP8.5) emission scenarios, with a higher decreasing rate under RCP8.5. 展开更多
关键词 wind speed SIMULATION PROJECTION BCC-CSM Representative Concentration Pathway(RCP)
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