Aquaporin-3 promotes proliferation and inflammation in hepatocellular carcinoma

Carcinogenesis is closely associated with inflammation.Studies have shown that lipopolysaccharides(LPS)can contribute to hepatocellular carcinoma(HC)development by inducing IL-6 and TNF-αproduction from the hepatic progenitor cells.1 Aquaporin 3(AQP3),a water channel protein,has recently been found to play a critical role in cancer-associated inflammation.

Alleviative effects of a novel strain Bacillus coagulans XY2 on copper-induced toxicity in zebrafish larvae

Copper (Cu) is a kind of micronutrient element that is essential for human metabolism.However,it is also considered as an environmental pollutant which is toxic to organisms at a high concentration level.Probiotics,regarded as beneficial microorganisms for promoting human health,have functions of antioxidant capacity,immune-enhancing properties,intestinal barrier protection and regulation.Several studies have reported that probiotics show positive effects on alleviating and intervening heavy metals toxicity.However,evidence for relieving copper-induced toxicity by probiotics is still limited.In this study,we firstly conducted a zebrafish larvae model to screen out microorganisms which are helpful for CuSO_(4)toxicity resistance and one novel strain named as Bacillus coagulans XY2 was discovered with the best protective activity.B.coagulans XY2 significantly reduced the mortality of zebrafish larvae exposed to 10μmol/L CuSO_(4)for 96 hr,as well as alleviated the neutrophils infiltration in the larvae lateral line under a 2 hr exposure.B.coagulans XY2 exhibited a high in vitro antioxidant activity and against CuSO_(4)-induced oxidative stress in zebrafish larvae by up-regulating sod1,gstp1 and cat gene transcriptional levels and relevant enzymatic activities.CuSO_(4)stimulated the inflammation process resulting in obvious increases of gene il-1βand il-10 transcription,which were suppressed by B.coagulans XY2 intervention.Overall,our results underline the bio-function of B.coagulans XY2 on protecting zebrafish larvae from copper toxicity,suggesting the potential application values of probiotics in copper toxicity alleviation on human and the environment.

Rational manipulation of composition and construction toward Zn/Co bimetal hybrids for electromagnetic wave absorption

Rational manipulation of multi-metal hybrids with controllable compositions and constructions is evolv-ing as an efficacious strategy for tunable electromagnetic(EM)characteristics and EM wave(EMW)ab-sorption.Herein,a novel bi-orientation etching approach is proposed to regulate the chemical composi-tions and hybridization construction of Zn/Co hybrids,thence meeting the synergistic interaction among diverse compositions for ultra-high EMW absorption.Attributing to the stepwise heterometallic modi-fication by Zn in Co-ZIFs(Zn@Co-ZIF)and Co in Zn-ZIFs(Co@Zn-ZIF),corresponding pyrolysis products with variable Zn/Co atomic concentration and hybridization states(Zn@Co-C,Co@Zn-C)can be obtained.The Co species was confirmed to have a positive impact on both the dielectric and magnetic response,while an appropriate amount of Zn hybridization in Co substance further enhanced the synergistic ef-fect between multiple loss mechanisms,promoting the minimum reflection loss and effective absorption bandwidth of Zn@Co-C reached-34.99 dB and 5.52 GHz(2.00 mm),respectively.Finally,this work re-veals the composition and construction dependency of bimetal hybrids on EMW absorption,which can be a strong reference for developing EMAs with diverse hybridization structures.