Bioinspired integrated triboelectric electronic tongue

An electronic tongue(E-tongue)comprises a series of sensors that simulate human perception of taste and embedded artificial intelligence(AI)for data analysis and recognition.Traditional E-tongues based on electrochemical methods suffer from a bulky size and require larger sample volumes and extra power sources,limiting their applications in in vivo medical diagnosis and analytical chemistry.Inspired by the mechanics of the human tongue,triboelectric components have been incorporated into E-tongue platforms to overcome these limitations.In this study,an integrated multichannel triboelectric bioinspired E-tongue(TBIET)device was developed on a single glass slide chip to improve the device’s taste classification accuracy by utilizing numerous sensory signals.The detection capability of the TBIET was further validated using various test samples,including representative human body,environmental,and beverage samples.The TBIET achieved a remarkably high classification accuracy.For instance,chemical solutions showed 100%identification accuracy,environmental samples reached 98.3%accuracy,and four typical teas demonstrated 97.0%accuracy.Additionally,the classification accuracy of NaCl solutions with five different concentrations reached 96.9%.The innovative TBIET exhibits a remarkable capacity to detect and analyze droplets with ultrahigh sensitivity to their electrical properties.Moreover,it offers a high degree of reliability in accurately detecting and analyzing various liquid samples within a short timeframe.The development of a self-powered portable triboelectric E-tongue prototype is a notable advancement in the field and is one that can greatly enhance the feasibility of rapid on-site detection of liquid samples in various settings.

Near-resonance enhanced label-free stimulated Raman scattering microscopy with spatial resolution near 130 nm

High-resolution optical microscopes that can break 180 nm in spatial resolution set to conventional microscopies are much-needed tools.However,current optical microscopes have to rely on exogenous fluorescent labels to achieve high resolution in biological imaging.Herein,we report near-resonance enhanced label-free stimulated Raman scattering(SRS)microscopy with a lateral resolution near 130 nm,in which the high-resolution image contrast originates directly from a low concentration of endogenous biomolecules,with sensitivity gains of approximately 23 times.Moreover,by using a 0.3-m-long optical fiber,we developed hyperspectral SRS microscopy based on spectral focusing technology.Attributed to enhancements in spatial resolution and sensitivity,we demonstrated highresolution imaging of three-dimensional structures in single cells and high-resolution mapping of large-scale intact mouse brain tissues in situ.By using enhanced high-resolution hyperspectral SRS,we chemically observed sphingomyelin distributed in the myelin sheath that insulates single axons.Our concept opens the door to biomedical imaging with~130 nm resolution.