Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fer...Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different ADG.Twelve calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host phenotype.Results During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,P<0.05).Enrichment of these bacteria resulted in increased levels of propionate,a gluconeogenic precursor,in preweaning HADG calves(adjusted P<0.05),which consequently raised serum glucose concentrations(adjusted P<0.05).In contrast,the relative abundances of rumen bacteria in post-weaning HADG calves did not exert this effect.Moreover,no significant differences were observed in rumen fermentation parameters and serum indices between the two groups.Conclusions The findings of this study revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.展开更多
BACKGROUND Several previous studies have reported an unusual root formation in which a fractured apical fragment of an immature root continued to develop independent of the main root after trauma to an immature tooth....BACKGROUND Several previous studies have reported an unusual root formation in which a fractured apical fragment of an immature root continued to develop independent of the main root after trauma to an immature tooth.To date,there have been only rare reports of the continuing apical formation of the fractured root associated with dens evaginatus(DE).This paper presents a case of a separated root tip formation associated with a fractured tubercle of DE.CASE SUMMARY An 11-year-old boy was referred for gingival sinus on the buccal side of the right mandibular second premolar(tooth#45).Clinically,tooth#45 was free of caries,but there was a sign of a fractured tubercle of DE on the occlusal surface.Radiography showed that the root canal of tooth#45 was widely radiolucent.A separated root apex was found apically under the main root and was nearly completely formed with an apical orifice at the apical tip.Tooth#45 was diagnosed as tubular fracture of DE with chronic apical periodontitis.A revascularization technique was recommended to treat the tooth.At 3-mo and 1-yr follow-up,the patient remained asymptomatic.Periapical radiography revealed that the separated root tip distally drifted with closure of the apex.However,the root length and thickness of the main root did not increased.CONCLUSION Clinicians should be aware that even if tubercle of DE is fractured in an immature tooth,the root tip may be separated from the main root and completely formed.展开更多
Background:This study investigated greenhouse gas(GHG)emission characteristics of lactating Holstein dairy cows in East China and provided a basis for formulating GHG emission reduction measures.GreenFeed system was u...Background:This study investigated greenhouse gas(GHG)emission characteristics of lactating Holstein dairy cows in East China and provided a basis for formulating GHG emission reduction measures.GreenFeed system was used to measure the amount of methane(CH_(4))and carbon dioxide(CO_(2))emitted by the cows through respiration.Data from a commercial cow farm were used to observe the effects of parity,body weight,milk yield,and milk component yield on CH_(4) and CO_(2) emissions.Results:Mean herd responses throughout the study were as follows:111 cows completed all experimental processes,while 42 cows were rejected because they were sick or had not visited the GreenFeed system 20 times.On average,lactating days of cows was 138±19.04 d,metabolic weight was 136.5±9.5 kg,parity was 2.8±1.0,dry matter intake(DMI)was 23.1±2.6 kg/d,and milk yield was 38.1±6.9 kg/d.The GreenFeed system revealed that CH_(4) production(expressed in CO_(2) equivalent,CO_(2)-eq)was found to be 8304 g/d,CH_(4)_(CO_(2)−eq)/DMI was 359 g/kg,CH_(4)_(CO_(2)−eq)/energy-corrected milk(ECM)was 229.5 g/kg,total CO_(2) production(CH_(4) production plus CO_(2) production)was 19,201 g/d,total CO_(2)/DMI was 831 g/kg,and total CO_(2)/ECM was 531 g/kg.The parity and metabolic weight of cows had no significant effect on total CO_(2) emissions(P>0.05).Cows with high milk yield,milk fat yield,milk protein yield,and total milk solids yield produced more total CO_(2)(P<0.05),but their total CO_(2) production per kg of ECM was low(P<0.05).The total CO_(2)/ECM of the medium and high milk yield groups was 17%and 27%lower than that of the low milk yield group,respectively.Conclusions:The parity and body condition had no effect on total CO_(2) emissions,while the total CO_(2)/ECM was negatively correlated with milk yield,milk fat yield,milk protein yield,and total milk solids yield in lactating Holstein dairy cows.Measurement of total CO_(2) emissions of dairy cows in the Chinese production system will help establish regional or national GHG inventories and develop mitigation approaches to dairy production regimes.展开更多
Background： Garlic extracts have been reported to be effective in reducing methanogenesis. Related mechanisms are not well illustrated, however, and most studies have been conducted in vitro. This study investigates ...Background： Garlic extracts have been reported to be effective in reducing methanogenesis. Related mechanisms are not well illustrated, however, and most studies have been conducted in vitro. This study investigates the effects of supplementary allicin（AL） in sheep diet on in vivo digestibility, rumen fermentation, and shifts of microbial flora.Methods： Two experiments were conducted using Dorper × thin-tailed Han crossbred ewes. In experiment 1,eighteen ewes（60.0 ± 1.73 kg BW） were randomly assigned for 29 days to either of two dietary treatments： a basal diet or the basal diet supplemented with 2.0 g AL/head？day to investigate supplementary AL on nutrient digestibility and methane emissions. In experiment 2, six ewes（65.2 ± 2.0 kg BW） with ruminal canulas were assigned to the same two dietary treatments as in experiment 1 for 42 days to investigate supplementary AL on ruminal fermentation and microbial flora. The methane emissions were determined using an open-circuit respirometry system and microbial assessment was done by q PCR of 16 S r RNA genes.Results： Supplementary AL increased the apparent digestibility of organic matter（P 〈 0.001）, nitrogen（P = 0.006）,neutral detergent fiber（P 〈 0.001）, and acid detergent fiber（P = 0.002）. Fecal nitrogen output was reduced（P = 0.001）but urinary nitrogen output was unaffected（P = 0.691）, while nitrogen retention（P = 0.077） and nitrogen retention/nitrogen intake（P = 0.077） tended to increase. Supplementary AL decreased methane emissions scaled to metabolic bodyweight by 5.95 %（P = 0.007） and to digestible organic matter intake by 8.36 %（P = 0.009）. Ruminal p H was unaffected（P = 0.601） while ammonia decreased（P = 0.024） and total volatile fatty acids increased（P = 0.024） in response to supplementary AL. Supplementary AL decreased the population of methanogens（P = 0.001） and tended to decrease that of protozoans（P = 0.097）, but increased the populations of F. succinogenes（P 〈 0.001）, R. flavefaciens（P = 0.001）, and B. fibrisolvens（P = 0.001）.Conclusions： Supplementation of AL at 2.0 g/head？day effectively enhanced OM, N, NDF, and ADF digestibility and reduced daily methane emissions（L/kg BW0.75） in ewes, probably by decreasing the population of ruminal protozoans and methanogens.展开更多
Ischemic mitral regurgitation （IMR） is a common complication of acute myocardial infarction （AMI）. Current evidences suggest that revascularization of the culprit vessels with percutaneous coronary artery interven...Ischemic mitral regurgitation （IMR） is a common complication of acute myocardial infarction （AMI）. Current evidences suggest that revascularization of the culprit vessels with percutaneous coronary artery intervention （PCI） or coronary artery bypass grafting can be beneficial for relieving IMR. A 2.5-year follow-up data of a 61-year-old male patient with ST-segment elevation AMI complicated with IMR showed that mitral regurgitation area increased five days after PCI, and decreased to lower steady level three months after PCI. This finding suggest that three months after PCI might be a suitable time point for evaluating the possibility oflMR recovery and the necessity of surgical intervention of the mitral valve for AMI patient.展开更多
Background： Dorper is an important breed for meat purpose and widely used in the livestock industry of the world.However, the protein requirement of Dorper crossbred has not been investigated. The current paper repor...Background： Dorper is an important breed for meat purpose and widely used in the livestock industry of the world.However, the protein requirement of Dorper crossbred has not been investigated. The current paper reports the net protein（NP） and metabolizable protein（MP） requirements of Dorper crossbred ram lambs from 20 to 35 kg BW.Methods： Thirty-five Dorper × thin-tailed Han crossbred lambs weaned at approximately 50 d of age（20.3 ± 2.15 kg of BW） were used. Seven lambs of 25 kg BW were slaughtered as the baseline animals at the start of the trial. An intermediate group of seven randomly selected lambs fed ad libitum was slaughtered at 28.6 kg BW. The remaining 21 lambs were randomly divided into three levels of dry matter intake： ad libitum or 70% or 40% of ad libitum intake. Those lambs were slaughtered when the lambs fed ad libitum reached 35 kg BW. Total body N and N retention were measured.Results： The daily NP and MP requirements for maintenance were 1.89 and 4.52 g/kg metabolic shrunk BW（SBW0.75）.The partial efficiency of MP utilization for maintenance was 0.42. The NP requirement for growth ranged from 12.1 to 43.5 g/d, for the lambs gaining 100 to 350 g/d, and the partial efficiency of MP utilization for growth was 0.86.Conclusions： The NP and MP requirements for the maintenance and growth of Dorper crossbred male lambs were lower than the recommendations of American and British nutritional systems.展开更多
Objective: To explore the effects of respiratory rehabilitation training combined with Corbrin Capsule on the inflammatory response and pulmonary fibrosis in patients with silicosis complicated by COPD. Methods: A tot...Objective: To explore the effects of respiratory rehabilitation training combined with Corbrin Capsule on the inflammatory response and pulmonary fibrosis in patients with silicosis complicated by COPD. Methods: A total of 80 patients with silicosis complicated by COPD who were treated in our hospital between January 2013 and December 2016 were selected as the research subjects and randomly divided into control group (n=40) and observation group (n=40). Control group were treated with Corbrin Capsule on the basis of routine treatment, and observation group were treated with respiratory rehabilitation training combined with Corbrin Capsule on the basis of routine treatment. The differences in serum levels of inflammatory factors and pulmonary fibrosis indexes were compared between the two groups before intervention, after 6 months of intervention and after 1 year of intervention. Results: Before intervention, there was no statistically significant difference in serum levels of inflammatory factors and pulmonary fibrosis indexes between the two groups. After 6 months of intervention and after 1 year of intervention, serum inflammatory factors IL-6, IL-8, IL-12, IL-17, IL-18 and MCP-1 levels of observation group were lower than those of control group;serum pulmonary fibrosis indexes PCⅢ, LN, HA, ICAM-1 and HO-1 contents were lower than those of control group. Conclusion: Respiratory rehabilitation training combined with Corbrin Capsule therapy can effectively reduce the systemic inflammatory response and inhibit the pulmonary fibrosis process in patients with silicosis complicated by COPD.展开更多
BACKGROUND Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported,all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic ...BACKGROUND Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported,all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy,but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial.CASE SUMMARY This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. She accepted surgery to remove the mass; she was found to have lung metastasis after radiotherapy.Her condition was controlled by chemotherapy with liposomal doxorubicin plus cisplatin.CONCLUSION The positive clinical outcome in the patient reveals that this chemotherapy regimen may be an alternative treatment for such a condition.展开更多
The weak van der Waals gap endows two dimensional transition metal dichalcogenides(2D TMDs)with the potential to realize guest intercalation and host exfoliation.Intriguingly,the liquid intercalation and exfoliation i...The weak van der Waals gap endows two dimensional transition metal dichalcogenides(2D TMDs)with the potential to realize guest intercalation and host exfoliation.Intriguingly,the liquid intercalation and exfoliation is a facile,low-cost,versatile and scalable strategy to modulate the structure and physiochemical property of TMDs via introducing foreign species into interlayer.In this review,firstly,we briefly introduce the resultant hybrid superlattice and disperse nanosheets with tailored properties fabricated via liquid intercalation and exfoliation.Subsequently,we systematically analyze the intercalation phenomenon and limitations of various intercalants in chemical or electrochemical methods.Afterwards,we intensely discuss diverse functionalities of resultant materials,focusing on their potential applications in energy conversion,energy storage,water purification,electronics,thermoelectrics and superconductor.Finally,we highlight the challenges and outlooks for precise and mass production of 2D TMDs-based materials via liquid intercalation and exfoliation.This review enriches the overview of liquid intercalation and exfoliation strategy,and paves the path for relevant high-performance devices.展开更多
As a new type of methane control agent, natural plant extract has been widely studied in recent years,but in vivo studies are few. This study was to investigate the effects of the dietary supplementation of 2 differen...As a new type of methane control agent, natural plant extract has been widely studied in recent years,but in vivo studies are few. This study was to investigate the effects of the dietary supplementation of 2 different polyphenols on the methane（CH4） emission and digestion metabolism in sheep. Ten healthy crossbred sheep（Dorper（?）× small-tailed Han ♀; BW 60.0 ± 1.73 kg） were used in a change-over design.The sheep were fed the following 3 diets in the present study: the basal diet（CON） with no supplementation; the basal diet supplemented with 2 g mulberry leaf flavonoid（MLF） per day per sheep; the basal diet supplemented with 0.25 g resveratrol（RES） per day per sheep. Both MLF and RES reduced CH4 emission scaled to metabolic weight per kilogram of DMI and CO2 output scaled to metabolic weight, but the effect of RES was significant（P < 0.05）. Both MLF and RES significantly improved apparent digestibility of DM, OM, NDF, ADF, and nitrogen, but the effect of RES was significant（P < 0.05）. Both MLF and RES significantly improved ME（P < 0.05） and reduced energy losses in CH4 emission（P > 0.05）. In conclusion, MLF and RES can improve the digestibility of nutrients, the utilization of nutrients and energy, and reduce CH4 emission, but they are not conducive to nitrogen retention.展开更多
基金funded by National Key R&D Program of China(2022YFA1304204)Agricultural Science and Technology Innovation Program(CAAS-ASTIP-2017-FRI-04)Beijing Innovation Consortium of livestock Research System(BAIC05-2023)。
文摘Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different ADG.Twelve calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host phenotype.Results During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,P<0.05).Enrichment of these bacteria resulted in increased levels of propionate,a gluconeogenic precursor,in preweaning HADG calves(adjusted P<0.05),which consequently raised serum glucose concentrations(adjusted P<0.05).In contrast,the relative abundances of rumen bacteria in post-weaning HADG calves did not exert this effect.Moreover,no significant differences were observed in rumen fermentation parameters and serum indices between the two groups.Conclusions The findings of this study revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.
基金National Natural Science Foundation of China,No.81801028Natural Science Foundation of Zhejiang Province,No.LQ19H140001.
文摘BACKGROUND Several previous studies have reported an unusual root formation in which a fractured apical fragment of an immature root continued to develop independent of the main root after trauma to an immature tooth.To date,there have been only rare reports of the continuing apical formation of the fractured root associated with dens evaginatus(DE).This paper presents a case of a separated root tip formation associated with a fractured tubercle of DE.CASE SUMMARY An 11-year-old boy was referred for gingival sinus on the buccal side of the right mandibular second premolar(tooth#45).Clinically,tooth#45 was free of caries,but there was a sign of a fractured tubercle of DE on the occlusal surface.Radiography showed that the root canal of tooth#45 was widely radiolucent.A separated root apex was found apically under the main root and was nearly completely formed with an apical orifice at the apical tip.Tooth#45 was diagnosed as tubular fracture of DE with chronic apical periodontitis.A revascularization technique was recommended to treat the tooth.At 3-mo and 1-yr follow-up,the patient remained asymptomatic.Periapical radiography revealed that the separated root tip distally drifted with closure of the apex.However,the root length and thickness of the main root did not increased.CONCLUSION Clinicians should be aware that even if tubercle of DE is fractured in an immature tooth,the root tip may be separated from the main root and completely formed.
基金funded by the Central Public-interest Scientific Institution Basal Research Fund of Chinese Academy of Agricultural Sciences(No.Y2022GH12)the Agricultural Science and Technology Innovation Program(CAAS-ASTIP-2017-FRI-04).
文摘Background:This study investigated greenhouse gas(GHG)emission characteristics of lactating Holstein dairy cows in East China and provided a basis for formulating GHG emission reduction measures.GreenFeed system was used to measure the amount of methane(CH_(4))and carbon dioxide(CO_(2))emitted by the cows through respiration.Data from a commercial cow farm were used to observe the effects of parity,body weight,milk yield,and milk component yield on CH_(4) and CO_(2) emissions.Results:Mean herd responses throughout the study were as follows:111 cows completed all experimental processes,while 42 cows were rejected because they were sick or had not visited the GreenFeed system 20 times.On average,lactating days of cows was 138±19.04 d,metabolic weight was 136.5±9.5 kg,parity was 2.8±1.0,dry matter intake(DMI)was 23.1±2.6 kg/d,and milk yield was 38.1±6.9 kg/d.The GreenFeed system revealed that CH_(4) production(expressed in CO_(2) equivalent,CO_(2)-eq)was found to be 8304 g/d,CH_(4)_(CO_(2)−eq)/DMI was 359 g/kg,CH_(4)_(CO_(2)−eq)/energy-corrected milk(ECM)was 229.5 g/kg,total CO_(2) production(CH_(4) production plus CO_(2) production)was 19,201 g/d,total CO_(2)/DMI was 831 g/kg,and total CO_(2)/ECM was 531 g/kg.The parity and metabolic weight of cows had no significant effect on total CO_(2) emissions(P>0.05).Cows with high milk yield,milk fat yield,milk protein yield,and total milk solids yield produced more total CO_(2)(P<0.05),but their total CO_(2) production per kg of ECM was low(P<0.05).The total CO_(2)/ECM of the medium and high milk yield groups was 17%and 27%lower than that of the low milk yield group,respectively.Conclusions:The parity and body condition had no effect on total CO_(2) emissions,while the total CO_(2)/ECM was negatively correlated with milk yield,milk fat yield,milk protein yield,and total milk solids yield in lactating Holstein dairy cows.Measurement of total CO_(2) emissions of dairy cows in the Chinese production system will help establish regional or national GHG inventories and develop mitigation approaches to dairy production regimes.
基金funded by the Ministry of Science and Technology of the People’s Republic of China (Program 2012BAD39B05)earmarked fund for China Agriculture Research System (CARS-39)
文摘Background： Garlic extracts have been reported to be effective in reducing methanogenesis. Related mechanisms are not well illustrated, however, and most studies have been conducted in vitro. This study investigates the effects of supplementary allicin（AL） in sheep diet on in vivo digestibility, rumen fermentation, and shifts of microbial flora.Methods： Two experiments were conducted using Dorper × thin-tailed Han crossbred ewes. In experiment 1,eighteen ewes（60.0 ± 1.73 kg BW） were randomly assigned for 29 days to either of two dietary treatments： a basal diet or the basal diet supplemented with 2.0 g AL/head？day to investigate supplementary AL on nutrient digestibility and methane emissions. In experiment 2, six ewes（65.2 ± 2.0 kg BW） with ruminal canulas were assigned to the same two dietary treatments as in experiment 1 for 42 days to investigate supplementary AL on ruminal fermentation and microbial flora. The methane emissions were determined using an open-circuit respirometry system and microbial assessment was done by q PCR of 16 S r RNA genes.Results： Supplementary AL increased the apparent digestibility of organic matter（P 〈 0.001）, nitrogen（P = 0.006）,neutral detergent fiber（P 〈 0.001）, and acid detergent fiber（P = 0.002）. Fecal nitrogen output was reduced（P = 0.001）but urinary nitrogen output was unaffected（P = 0.691）, while nitrogen retention（P = 0.077） and nitrogen retention/nitrogen intake（P = 0.077） tended to increase. Supplementary AL decreased methane emissions scaled to metabolic bodyweight by 5.95 %（P = 0.007） and to digestible organic matter intake by 8.36 %（P = 0.009）. Ruminal p H was unaffected（P = 0.601） while ammonia decreased（P = 0.024） and total volatile fatty acids increased（P = 0.024） in response to supplementary AL. Supplementary AL decreased the population of methanogens（P = 0.001） and tended to decrease that of protozoans（P = 0.097）, but increased the populations of F. succinogenes（P 〈 0.001）, R. flavefaciens（P = 0.001）, and B. fibrisolvens（P = 0.001）.Conclusions： Supplementation of AL at 2.0 g/head？day effectively enhanced OM, N, NDF, and ADF digestibility and reduced daily methane emissions（L/kg BW0.75） in ewes, probably by decreasing the population of ruminal protozoans and methanogens.
基金Acknowledgement This project were supported by the President＇s Grant of Nanfang Hospital （2014H002）, the General Education Reform Project of Innovation to Enhance University in Guangdong Province 2015, Natural Science Foundation of Guangdong Province （2015A030310441）, and National Natural Science Foundation of China （81570352）.
文摘Ischemic mitral regurgitation （IMR） is a common complication of acute myocardial infarction （AMI）. Current evidences suggest that revascularization of the culprit vessels with percutaneous coronary artery intervention （PCI） or coronary artery bypass grafting can be beneficial for relieving IMR. A 2.5-year follow-up data of a 61-year-old male patient with ST-segment elevation AMI complicated with IMR showed that mitral regurgitation area increased five days after PCI, and decreased to lower steady level three months after PCI. This finding suggest that three months after PCI might be a suitable time point for evaluating the possibility oflMR recovery and the necessity of surgical intervention of the mitral valve for AMI patient.
基金supported by the earmarked fund for the China Agriculture Research System(CARS-39)
文摘Background： Dorper is an important breed for meat purpose and widely used in the livestock industry of the world.However, the protein requirement of Dorper crossbred has not been investigated. The current paper reports the net protein（NP） and metabolizable protein（MP） requirements of Dorper crossbred ram lambs from 20 to 35 kg BW.Methods： Thirty-five Dorper × thin-tailed Han crossbred lambs weaned at approximately 50 d of age（20.3 ± 2.15 kg of BW） were used. Seven lambs of 25 kg BW were slaughtered as the baseline animals at the start of the trial. An intermediate group of seven randomly selected lambs fed ad libitum was slaughtered at 28.6 kg BW. The remaining 21 lambs were randomly divided into three levels of dry matter intake： ad libitum or 70% or 40% of ad libitum intake. Those lambs were slaughtered when the lambs fed ad libitum reached 35 kg BW. Total body N and N retention were measured.Results： The daily NP and MP requirements for maintenance were 1.89 and 4.52 g/kg metabolic shrunk BW（SBW0.75）.The partial efficiency of MP utilization for maintenance was 0.42. The NP requirement for growth ranged from 12.1 to 43.5 g/d, for the lambs gaining 100 to 350 g/d, and the partial efficiency of MP utilization for growth was 0.86.Conclusions： The NP and MP requirements for the maintenance and growth of Dorper crossbred male lambs were lower than the recommendations of American and British nutritional systems.
基金Hubei Provincial Natural Science Foundation Project(Grant No.2014CFB478).
文摘Objective: To explore the effects of respiratory rehabilitation training combined with Corbrin Capsule on the inflammatory response and pulmonary fibrosis in patients with silicosis complicated by COPD. Methods: A total of 80 patients with silicosis complicated by COPD who were treated in our hospital between January 2013 and December 2016 were selected as the research subjects and randomly divided into control group (n=40) and observation group (n=40). Control group were treated with Corbrin Capsule on the basis of routine treatment, and observation group were treated with respiratory rehabilitation training combined with Corbrin Capsule on the basis of routine treatment. The differences in serum levels of inflammatory factors and pulmonary fibrosis indexes were compared between the two groups before intervention, after 6 months of intervention and after 1 year of intervention. Results: Before intervention, there was no statistically significant difference in serum levels of inflammatory factors and pulmonary fibrosis indexes between the two groups. After 6 months of intervention and after 1 year of intervention, serum inflammatory factors IL-6, IL-8, IL-12, IL-17, IL-18 and MCP-1 levels of observation group were lower than those of control group;serum pulmonary fibrosis indexes PCⅢ, LN, HA, ICAM-1 and HO-1 contents were lower than those of control group. Conclusion: Respiratory rehabilitation training combined with Corbrin Capsule therapy can effectively reduce the systemic inflammatory response and inhibit the pulmonary fibrosis process in patients with silicosis complicated by COPD.
文摘BACKGROUND Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported,all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy,but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial.CASE SUMMARY This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. She accepted surgery to remove the mass; she was found to have lung metastasis after radiotherapy.Her condition was controlled by chemotherapy with liposomal doxorubicin plus cisplatin.CONCLUSION The positive clinical outcome in the patient reveals that this chemotherapy regimen may be an alternative treatment for such a condition.
基金supported by the National Natural Science Foundation of China(Nos.51902101,61775101,62288102,and 61804082)the Youth Natural Science Foundation of Hunan Province(No.2021JJ40044)the Natural Science Foundation of Jiangsu Province(No.BK20201381).
文摘The weak van der Waals gap endows two dimensional transition metal dichalcogenides(2D TMDs)with the potential to realize guest intercalation and host exfoliation.Intriguingly,the liquid intercalation and exfoliation is a facile,low-cost,versatile and scalable strategy to modulate the structure and physiochemical property of TMDs via introducing foreign species into interlayer.In this review,firstly,we briefly introduce the resultant hybrid superlattice and disperse nanosheets with tailored properties fabricated via liquid intercalation and exfoliation.Subsequently,we systematically analyze the intercalation phenomenon and limitations of various intercalants in chemical or electrochemical methods.Afterwards,we intensely discuss diverse functionalities of resultant materials,focusing on their potential applications in energy conversion,energy storage,water purification,electronics,thermoelectrics and superconductor.Finally,we highlight the challenges and outlooks for precise and mass production of 2D TMDs-based materials via liquid intercalation and exfoliation.This review enriches the overview of liquid intercalation and exfoliation strategy,and paves the path for relevant high-performance devices.
基金supported by the earmarked fund for the Modern Agro-Industry Technology Research System,China(CARS-39,200903006)To Build Healthy Farming Model and Demonstrate for Sheep(2012BAD39B05-3)
文摘As a new type of methane control agent, natural plant extract has been widely studied in recent years,but in vivo studies are few. This study was to investigate the effects of the dietary supplementation of 2 different polyphenols on the methane（CH4） emission and digestion metabolism in sheep. Ten healthy crossbred sheep（Dorper（?）× small-tailed Han ♀; BW 60.0 ± 1.73 kg） were used in a change-over design.The sheep were fed the following 3 diets in the present study: the basal diet（CON） with no supplementation; the basal diet supplemented with 2 g mulberry leaf flavonoid（MLF） per day per sheep; the basal diet supplemented with 0.25 g resveratrol（RES） per day per sheep. Both MLF and RES reduced CH4 emission scaled to metabolic weight per kilogram of DMI and CO2 output scaled to metabolic weight, but the effect of RES was significant（P < 0.05）. Both MLF and RES significantly improved apparent digestibility of DM, OM, NDF, ADF, and nitrogen, but the effect of RES was significant（P < 0.05）. Both MLF and RES significantly improved ME（P < 0.05） and reduced energy losses in CH4 emission（P > 0.05）. In conclusion, MLF and RES can improve the digestibility of nutrients, the utilization of nutrients and energy, and reduce CH4 emission, but they are not conducive to nitrogen retention.
