Synthesis and characterization of spinel Li_(1.05)Cr_(0.1)Mn_(1.9)O_(4-z)F_z as cathode materials for lithium-ion batteries

Samples with the nominal stoichiometry Li1.05Cr0.1Mn1.9O4-zFz（z=0,0.05,0.1,0.15,and 0.2） were synthesized via the solid-state reaction method and characterized by X-ray powder diffraction（XRD）,scanning electron microscopy（SEM）,galvanostatic charge/discharge, and slow rate cyclic voltammetry（SSCV） techniques.The results show that the pure spinel phase indexed to Fd3m can be obtained when z=0, 0.05,and 0.1.The substitution of F for O with z≤0.1 contributes to the increase of initial capacity compared with Li1.05Cr0.1Mn1.9O4 spinels. However,when the F-dopant content is designed to be 0.15 and 0.2,the Li1.05Cr0.1Mn1.9O4-zFZ samples deliver relatively low capacity and poor cycling properties at 55℃.

Research on the mechanism of Chaihu Huangqin medicine based on integrated pharmacology to improve the clinical symptoms of COVID-19

Objective:Novel coronavirus(COVID-19)was used to improve the clinical symptoms of the new type coronavirus(LV),based on integrated pharmacology.Methods:TCMIP v2.0 was used to predict the key target and action pathway of Bupleurum baicalensis Georgi in improving the clinical symptoms of covid-19.The multi-dimensional network diagram of"drug pair active component key target action pathway"was drawn to explore its action mechanism from the molecular level.Results:Bupleurum and Scutellaria baicalensis could regulate IL signaling pathway and clec7a(a member of C-type lectin domain 7 family)/Inflammatory pathway,immune stress and other related signaling pathways can inhibit activated cytokines,alleviate excessive immune response,eliminate inflammation,and resist virus.In addition,the core targets of Bupleurum baicalensis baicalensis Georgi:nuclear factor kB(NFKB2,NFKB1),interleukin(IL-6,IL-1B),toll like receptor 4(TLR4),tumor necrosis factor(TNF)and so on are mostly induced by inflammation It is related to body damage.Bupleurum and scutellaria have the clinical effects of anti-inflammatory,antiviral,strengthening immunity,inhibiting pulmonary fibrosis and so on.Conclusion:Radix Bupleuri Scutellariae can be used to treat covid-19 by multi-channel,multi-target and multi ring.The results of this study provide a theoretical basis for Bupleurum Scutellaria to improve the use of COVID-19.

Research progress of Astragalus and Angelica

Astragalus angelica is a famous pair of Qi tonifying and blood enriching drugs.After compatibility,it can achieve the same effect,complement each other and promote each other.It can enhance human immunity,improve blood circulation,promote hematopoiesis,protect cardiovascular and cerebrovascular vessels,anti fibrosis,protect kidney,assist in the treatment of kidney syndrome,diabetes,children's cough,dizziness,improve cancer and other functions.In this paper,Astragalus Angelica pairs were systematically elaborated from its efficacy and material basis,pharmacological research and clinical application,and its further research was prospected,providing basis for the development of Astragalus Angelica pairs.

Clinical characteristics and risk factors associated with secondary bloodstream infection in patients with intensive care unit-acquired pneumonia due to carbapenem-resistant Klebsiella pneumoniae

The global spread of carbapenem-resistant Klebsiella pneumoniae(CRKP)has become a major healthcare burden because of the limited therapeutic options and poor prognosis,and this situation gets worse among patients admitted to intensive care unit(ICU).[1]CRKP can cause a range of infections,including pneumonia,urinary tract infection(UTI),and bloodstream infection(BSI).BSI is one of the most serious infections caused by CRKP and associated with high mortality ranging from 39%to 82%.[2]BSI due to CRKP could be primary infection or secondary infection that originated from primary infections in the lungs or bladder,and 50%of CRKP-BSIs originated from primary infections in the lungs.[3]Although previous studies have explored several risk factors for CRKP infections,the association between CRKP pneumonia and the development of secondary CRKP-BSI was not fully revealed thus far.The aim of this study was to predict risk factors of 28-day mortality and the development of secondary CRKP-BSI in ICU-acquired pneumonia caused by CRKP.

Microstructural evolution and numerical simulation of laser-welded Ti_(2)AlNb joints under different heat inputs

The influence of heat input on the microstructural evolution of laser-welded Ti_(2)AlNb joints was investigated in this study.The thermal cycles during welding process were analyzed by numerical simulation.In the heat affected zone(HAZ),the amount ofα_(2)and O phases decreased with laser power increasing.During the heating period,α_(2)→B2and O→B2transformations occurred,but the decomposition of the B2phase intoα_(2)and O phases was suppressed during the cooling period.The heat transfer in the HAZ generated more equiaxed B2grains,fewer LAGBs and a weaker{001}<110>texture due to recovery,recrystallization and grain growth.The phase composition of the fusion zone remained single with only the B2phase with the increase in heat input,but the mode of grain growth transformed from cellular growth into cellular dendritic growth.A finite element model was established to simulate the thermal cycles during the welding process.Higher heat input induced higher peak temperature,leading to higher temperatures in the HAZ for longer periods of time,which was beneficial for theα_(2)→B2and O→B2transformations.The calculated cooling rates in both the HAZ and in the fusion zone were faster than the critical cooling rate for B2→α_(2)and B2→O transformations.