Objective:To study the effect of heat-activated nickel-titanium arch wire for orthodontic treatment on local tissue inflammation and bone destruction.Methods:Patients who received orthodontic treatment with nickel-tit...Objective:To study the effect of heat-activated nickel-titanium arch wire for orthodontic treatment on local tissue inflammation and bone destruction.Methods:Patients who received orthodontic treatment with nickel-titanium arch wire in Hancheng People's Hospital between March 2012 and October 2017 were retrospectively studied, and according to the nickel-titanium arch wire materials in history data, the patients were divided into the experimental group who used heat-activated nickel-titanium arch wire and the control group who used common nickel-titanium arch wire. 1 week after treatment, the gingival crevicular fluid was collected to determine the contents of inflammatory cytokines as well as the mRNA expression of osteoblast markers and osteoclast markers.Results: 1 week after treatment, IL-1α, IL-1β, sTREM1 and HMGB1 contents as well as RANKL, 5-LOX, LTB4, TRACP5b and ODF mRNA expression in gingival crevicular fluid of experimental group were significantly lower than those of control group whereas OPG, Wnt3a, Runx2, OC, ALP and OCIF mRNA expression were significantly higher than those of control group.Conclusion: Heat-activated nickel-titanium arch wire for orthodontic treatment can be more effective than common nickel-titanium arch wire to reduce the local tissue inflammation and inhibit the bone destruction.展开更多
文摘Objective:To study the effect of heat-activated nickel-titanium arch wire for orthodontic treatment on local tissue inflammation and bone destruction.Methods:Patients who received orthodontic treatment with nickel-titanium arch wire in Hancheng People's Hospital between March 2012 and October 2017 were retrospectively studied, and according to the nickel-titanium arch wire materials in history data, the patients were divided into the experimental group who used heat-activated nickel-titanium arch wire and the control group who used common nickel-titanium arch wire. 1 week after treatment, the gingival crevicular fluid was collected to determine the contents of inflammatory cytokines as well as the mRNA expression of osteoblast markers and osteoclast markers.Results: 1 week after treatment, IL-1α, IL-1β, sTREM1 and HMGB1 contents as well as RANKL, 5-LOX, LTB4, TRACP5b and ODF mRNA expression in gingival crevicular fluid of experimental group were significantly lower than those of control group whereas OPG, Wnt3a, Runx2, OC, ALP and OCIF mRNA expression were significantly higher than those of control group.Conclusion: Heat-activated nickel-titanium arch wire for orthodontic treatment can be more effective than common nickel-titanium arch wire to reduce the local tissue inflammation and inhibit the bone destruction.
