Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,increasing in prevalence with age.Catheter ablation is recommended to symptomatic paroxysmal AF refractory or intolerant to at least one Class I o...Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,increasing in prevalence with age.Catheter ablation is recommended to symptomatic paroxysmal AF refractory or intolerant to at least one Class I or III antiarrhythmic medication.[1]Main current catheter ablation of AF with radiofrequency can give priority to,other include freezing,ultrasonic and laser ablation etc.Recent studies provides substantial information regarding the efficacy and safety of novel cryoballoon technology in creating pulmonary vein(PV)isolation.[2,3]Processed in cyroballoon ablation,some AF patients implanted with double chamber pacemaker are difficult to puncture atrial septal,because of the atrial electrode.My case report was as follows.展开更多
A series of novel diaryl ureas containing 4-[（2-amino-6-trifluromethyl）pyrimidine-4-yl]piperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compa...A series of novel diaryl ureas containing 4-[（2-amino-6-trifluromethyl）pyrimidine-4-yl]piperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer activities.Among them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_（50） values of 0.016,0.63,0.001μmol/L, respectively.展开更多
The planting of the vegetation on the floodplain helps the ecological restoration,which is the main form of the river’s ecological corridor.Therefore,the current research of the river dynamics focuses on the water mo...The planting of the vegetation on the floodplain helps the ecological restoration,which is the main form of the river’s ecological corridor.Therefore,the current research of the river dynamics focuses on the water movement under a compound channel with the vegetated floodplains.Two simulated vegetation species are selected in this paper for the flume simulation experiments of the floodplain vegetation,and the compound channel is divided into three subregions in the transverse direction.The Navier-Stokes equation and the eddy viscosity theory are applied to obtain the transverse distribution of the depth-averaged velocity and the results agree well with the experimental data.This paper proposes a new method based on the analytical solution of the flow velocity distribution to calculate the average flow velocity in each section.Calculation results can effectively simulate the average flow velocity of the measured sections.The description of the pollutant transport processes in a moving stream requires a refined determination of the dispersion coefficients in the compound channel.The process of the pollutant concentrations in each zone and the reasons for their occurrence are elucidated on the basis of the experimental results.Simultaneously,the measured values of the longitudinal dispersion coefficients are obtained by the“routing procedure,”and a two-zone model of the pollutant dispersion is constructed on the basis of the hydrodynamic study.The prediction method for the longitudinal dispersion coefficients is also presented.Applying the predicted and measured section average flow velocities to the two-zone model to predict the longitudinal dispersion coefficient,and the average relative errors are only 4.17%,7.15%,respectively.This result indicates that the two-zone model can effectively predict the longitudinal dispersion coefficients.The calculation methods for the longitudinal dispersion coefficients from—various studies are compared.The results reveal that the predicted values of these calculation methods are all larger than the measured values,indicating that the vegetation has a considerable influence on the dispersion process.This study comprehensively shows the dispersion features of the pollutants and provides a theoretical basis for the planning and the design of the vegetated ecological corridors.展开更多
Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were synthesized.The compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities agains...Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were synthesized.The compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring different forms of EGFR.Compounds 7f and7 k exhibited potent and selective activity in inhibition of gefitinib-resistant H1975 cancer cells（IC50;0.45,0.2μmol/L） while were much less active on A549 cancer cells（IC50;52.83,〉100μmol/L）.Both compounds could be served as promising lead compounds for further investigation.展开更多
文摘Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,increasing in prevalence with age.Catheter ablation is recommended to symptomatic paroxysmal AF refractory or intolerant to at least one Class I or III antiarrhythmic medication.[1]Main current catheter ablation of AF with radiofrequency can give priority to,other include freezing,ultrasonic and laser ablation etc.Recent studies provides substantial information regarding the efficacy and safety of novel cryoballoon technology in creating pulmonary vein(PV)isolation.[2,3]Processed in cyroballoon ablation,some AF patients implanted with double chamber pacemaker are difficult to puncture atrial septal,because of the atrial electrode.My case report was as follows.
基金Project supported by the National Natural Science Foundation of China(No.31772213)the Excellent Youth Fund of Zhejiang Province,China(No.LR17C140002)
基金supported by a grant from the National Natural Science Foundation of China(No.21002065)
文摘A series of novel diaryl ureas containing 4-[（2-amino-6-trifluromethyl）pyrimidine-4-yl]piperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer activities.Among them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_（50） values of 0.016,0.63,0.001μmol/L, respectively.
基金supported by the Research project of China Three Gorges Corporation(Grant No.202103399)the Talent Program of China Institute of Water Resources and Hydropower Research(Grant No.WE0199A052021)+2 种基金the Basic Scientific Research Expense Project of IWHR(Grant No.WR0145B022021)Project supported by the National Key Research and Development Program of China(Grant No.2019YFD1100205)the National Natural Science Foundation of China(Grant Nos.51809286,52209083,51809288,41501204 and U1802241).
文摘The planting of the vegetation on the floodplain helps the ecological restoration,which is the main form of the river’s ecological corridor.Therefore,the current research of the river dynamics focuses on the water movement under a compound channel with the vegetated floodplains.Two simulated vegetation species are selected in this paper for the flume simulation experiments of the floodplain vegetation,and the compound channel is divided into three subregions in the transverse direction.The Navier-Stokes equation and the eddy viscosity theory are applied to obtain the transverse distribution of the depth-averaged velocity and the results agree well with the experimental data.This paper proposes a new method based on the analytical solution of the flow velocity distribution to calculate the average flow velocity in each section.Calculation results can effectively simulate the average flow velocity of the measured sections.The description of the pollutant transport processes in a moving stream requires a refined determination of the dispersion coefficients in the compound channel.The process of the pollutant concentrations in each zone and the reasons for their occurrence are elucidated on the basis of the experimental results.Simultaneously,the measured values of the longitudinal dispersion coefficients are obtained by the“routing procedure,”and a two-zone model of the pollutant dispersion is constructed on the basis of the hydrodynamic study.The prediction method for the longitudinal dispersion coefficients is also presented.Applying the predicted and measured section average flow velocities to the two-zone model to predict the longitudinal dispersion coefficient,and the average relative errors are only 4.17%,7.15%,respectively.This result indicates that the two-zone model can effectively predict the longitudinal dispersion coefficients.The calculation methods for the longitudinal dispersion coefficients from—various studies are compared.The results reveal that the predicted values of these calculation methods are all larger than the measured values,indicating that the vegetation has a considerable influence on the dispersion process.This study comprehensively shows the dispersion features of the pollutants and provides a theoretical basis for the planning and the design of the vegetated ecological corridors.
基金supported by grants from Science Foundation of Shenyang Pharmaceutical University(No.QNJJ2014502)
文摘Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were synthesized.The compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring different forms of EGFR.Compounds 7f and7 k exhibited potent and selective activity in inhibition of gefitinib-resistant H1975 cancer cells（IC50;0.45,0.2μmol/L） while were much less active on A549 cancer cells（IC50;52.83,〉100μmol/L）.Both compounds could be served as promising lead compounds for further investigation.
