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青海卡尔却卡多金属矿床热液与化学反应耦合成矿过程的数值模拟(英文) 被引量:8
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作者 邹艳红 刘尧 +5 位作者 潘勇 阳宽达 戴塔根 毛先成 赖建清 田海龙 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2019年第1期165-177,共13页
青海卡尔却卡多金属矿床位于祁漫塔格成矿带,是一个典型的矽卡岩多金属矿床,该矿床形成的条件及详细动力学过程一直是地球科学研究工作中的重要课题。利用有限差分法对该地区的黄铜矿成矿过程进行数值建模,并在数值模拟中近似地考虑野... 青海卡尔却卡多金属矿床位于祁漫塔格成矿带,是一个典型的矽卡岩多金属矿床,该矿床形成的条件及详细动力学过程一直是地球科学研究工作中的重要课题。利用有限差分法对该地区的黄铜矿成矿过程进行数值建模,并在数值模拟中近似地考虑野外地质特征、成矿及其相关的地球化学条件。着重采用现代成矿理论定量地考虑卡尔却卡多金属矿床中黄铜矿的成矿化学反应过程。相关数值结果表明:含矿热液流动是该地区矿化的关键控制因素,而温度梯度是孔隙热液流体流动的主要驱动力。在卡尔却卡多金属矿床中,黄铜矿成矿的温度为250~350℃。这些相关的计算结果已通过地质勘查成果得到验证。由此表明:采用新兴计算地球科学中的成矿化学反应与有限差分模型耦合模拟方法有利于提高对该地区成矿过程的认识。 展开更多
关键词 数值模拟 热传递 化学反应 热液成矿 卡尔却卡多金属矿床
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霉酚酸酯对阿霉素肾病大鼠的保护作用及其机制研究 被引量:3
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作者 王兴 白明辉 +7 位作者 季佳 邹艳红 杨菲 邓李玲 范琳博 刘瑶 邱迪 刘秋红 《中国现代医学杂志》 CAS 2019年第4期1-8,共8页
目的探讨霉酚酸酯(MMF)对阿霉素肾病(ADN)大鼠足细胞的保护作用,以及对肾组织micro RNAs(mi RNAs)表达的影响。方法将60只SD大鼠随机分为空白对照组(CTL组)、ADN模型组(ADN组)和MMF干预组(MMF组),ADN组和MMF组大鼠一次性尾静脉注射阿霉... 目的探讨霉酚酸酯(MMF)对阿霉素肾病(ADN)大鼠足细胞的保护作用,以及对肾组织micro RNAs(mi RNAs)表达的影响。方法将60只SD大鼠随机分为空白对照组(CTL组)、ADN模型组(ADN组)和MMF干预组(MMF组),ADN组和MMF组大鼠一次性尾静脉注射阿霉素6.5 mg/kg,7 d后开始灌胃给药。28 d后处死所有受试大鼠,检测24 h尿蛋白量、血尿素氮(BUN)、血清肌酐(Scr)水平,以及肾组织病理学变化和足细胞凋亡情况;并借助基因芯片技术,分析肾组织mi RNAs表达的差异性;采用实时荧光定量聚合酶链反应(q RT-PCR)检测肾组织mi R-23a、mi R-300-3p、mi R-24和mi R-300-3c的表达。结果 3组大鼠不同时间点体重、尿蛋白含量比较,差异有统计学意义(P<0.05);与CTL组大鼠比较,ADN组大鼠体重减轻(P <0.05),肾组织损伤明显(P <0.05),尿蛋白、BUN、Scr水平升高(P <0.05),足细胞凋亡率较高(P <0.05);而MMF对ADN组大鼠上述变化有改善作用,但是与CTL组大鼠比较,差异有统计学意义(P <0.05)。经基因芯片筛查和q RT-PCR反应,ADN组大鼠肾组织rno-mi R-23a和rno-mi R-300-3p表达较CTL组上调(P<0.05),rno-mi R-24、rno-mi R-300-3c表达下调(P<0.05);而MMF组大鼠肾组织中rno-mi R-24、rno-mi R-300-3c表达较ADN组上调(P<0.05),rno-mi R-23a和rno-mi R-300-3p表达下调(P <0.05)。结论MMF具有抑制ADN大鼠肾组织足细胞损伤和蛋白尿生成的作用,其机制可能是对19号和6号染色体部分mi RNAs有干预作用。 展开更多
关键词 肾病 阿霉素/多柔比星 霉酚酸酯/酯类 大鼠 足细胞 MICRORNAS
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Use of Cataract Surgery in Urban Beijing: a Post Screening Follow-up of the Elderly with Visual Impairment due to Age-related Cataract 被引量:5
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作者 Xue-tao Ren Torkel Snellingen +7 位作者 Hong Gu Sawitri Assanangkornchai yan-hong zou Virasakdi Chongsuvivatwong Apiradee Lim Wei Jia Xi-pu Liu Ning-pu Liu 《Chinese Medical Sciences Journal》 CAS CSCD 2015年第1期1-6,共6页
Objective To understand the perception for the use of cataract surgical services in a population of acceptors and non-acceptors of cataract surgery in urban Beijing. Methods From a community-based screening program a ... Objective To understand the perception for the use of cataract surgical services in a population of acceptors and non-acceptors of cataract surgery in urban Beijing. Methods From a community-based screening program a total of 158 patients with presenting visual acuity of less than 6/18 on either eye due to age-related cataract were informed about the possibility of surgical treatment. These patients were interviewed and re-examined 36 to 46 months after initial screening. The main reasons for not accepting surgery were obtained using a questionnaire. Vision function and vision-related quality of life scores were assessed in those who received and did not receive surgery. Results At the follow-up examination 116 of the 158 patients were available and 36(31.0%) had undergone cataract surgery. Cases who chose surgery had higher education level than those who did not seek surgery(OR=2.64, 95% CI: 1.08-6.63, P=0.02). There were no significant differences in vision function(P=0.11) or quality of life scores(P=0.16) between the surgery group and the non-surgery group. Main reasons for not having surgery included no perceived need(50.0%), feeling of being "too old"(19.2%), and worry about the quality of surgery(9.6%). Cost was cited by 1(1.9%) subject as the main reason for not seeking surgery.Conclusions The data suggest that in China's capital urban center for patients with moderate visual impairment there is a relative low acceptance rate of cataract surgery, mainly due to people's perception of marginal benefits of surgery. Cost is not a determining factor as barrier to undergo surgery and patients with poorer education are less likely to undertake surgery. 展开更多
关键词 白内障手术 年龄相关 筛选 城市 北京 老年人 手术治疗 视觉功能
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矽卡岩矿床岩体形态定量分析及成矿关系——以安徽铜陵凤凰山铜矿床为例(英文) 被引量:5
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作者 毛先成 赵莹 +5 位作者 邓浩 张彬 刘占坤 陈进 邹艳红 赖健清 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2018年第1期151-162,共12页
矽卡岩型矿床矿体的形成和分布主要受岩浆岩的形态及其与围岩的接触带控制。以凤凰山铜矿新屋里岩体为实验对象,运用新方法获得侵入岩岩体形态与矽卡岩矿化的定量关系。首先,基于数学形态学和欧式距离变换,提取岩体三维形态特征参数;然... 矽卡岩型矿床矿体的形成和分布主要受岩浆岩的形态及其与围岩的接触带控制。以凤凰山铜矿新屋里岩体为实验对象,运用新方法获得侵入岩岩体形态与矽卡岩矿化的定量关系。首先,基于数学形态学和欧式距离变换,提取岩体三维形态特征参数;然后,分析形态参数和矿体之间的定量关系;最后,进行形态参数和矿化指标之间的相关性分析。结果表明,形态特征参数能有效指示矽卡岩矿床隐伏矿体位置,矿体主要位于:(1)距离一级趋势面-25~50 m的岩体部位;(2)距离二级趋势面200 m附近的外凸部位,附近岩体切平面与趋势面走向一致;(3)岩体原始接触面和趋势接触面之间的夹角为35°~70°的接触带;(4)岩体原始接触面与区域挤压远应力场之间的夹角为50°~60°的岩体部位。这些定量关系可以推广到其他矽卡岩矿床的矿产勘查中。 展开更多
关键词 岩体形态分析 接触带 数学形态学 矽卡岩矿化 凤凰山铜矿床
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Gonioscopy and Ultrasound Biomicroscopy in the Detection of Angle Closure in Patients with Shallow Anterior Chamber 被引量:2
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作者 Shan-shan Cui yan-hong zou +3 位作者 Qian Li Li-na Li Ning Zhang Xi-pu Liu 《Chinese Medical Sciences Journal》 CAS CSCD 2014年第4期204-207,共4页
Objective To assess the agreement between gonioscopy and ultrasound biomicroscopy(UBM) in detecting angle closure in Chinese patients with shallow anterior chamber. Methods An observational comparative study of the tw... Objective To assess the agreement between gonioscopy and ultrasound biomicroscopy(UBM) in detecting angle closure in Chinese patients with shallow anterior chamber. Methods An observational comparative study of the two different examination methods was conducted. Patients with normal intraocular pressure and temporal peripheral anterior chamber depth less than a quarter of corneal thickness based on slit lamp examination were included in this study from December 2007 to May 2009 in the outpatient clinic of First Hospital of Tsinghua University. Gonioscopy was performed with a Goldman goniolens in dark room first and followed by full beam light and indentation. If the filtering trabecular meshwork was invisible or any peripheral anterior synechia was found, that quadrant of the angle was considered closed. UBM was first undertaken in a darkened room then repeated with normal room lighting. If iridotrabecular apposition was showed, that quadrant of the angle was considered closed. The status of angle closure of each quadrant with different methods was recorded. Results 85 eyes of 46 patients were included in this study. The agreement between gonioscopy and UBM was poor(κ<0.4) with Kappa analysis in both dark and light conditions in each quadrant. The accordance of agreement between gonioscopy and UBM was hardly affected by age or sex, while in dark condition, eyes with deeper anterior chamber(P=0.005) or plateau iris configuration tended to produce different results(P=0.075) in the 2 methods. Conclusion Gonioscopy and UBM are both indispensable methods for detecting angle closure, neither can completely replace the other. 展开更多
关键词 GONIOSCOPY ULTRASOUND BIOMICROSCOPY ANGLE CLOSURE GLAUCOMA
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Comparison between Ophthalmologists and Community Health Workers in Screening of Shallow Anterior Chamber with Oblique Flashlight Test 被引量:1
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作者 Yusoh Nuriyah Xue-tao Ren +2 位作者 Li Jiang Xi-pu Liu yan-hong zou 《Chinese Medical Sciences Journal》 CAS CSCD 2010年第1期50-52,共3页
Objective To study the agreement between ophthalmologists and community health workers in detecting shallow anterior chamber with oblique flashlight test. Methods Totally 425 subjects were given an eye examination in ... Objective To study the agreement between ophthalmologists and community health workers in detecting shallow anterior chamber with oblique flashlight test. Methods Totally 425 subjects were given an eye examination in a community health center. The anterior chamber depth of each subject was examined by one ophthalmologist and two trained community health workers (one nurse and one non-professional health worker) using oblique flashlight test. Inter-observer agreement was determined using the weighted kappa statistic. Results Among the enrolled subjects,148 (35%) were male and 277 (65%) were female. Good agreement was noted in all the three observers. The comparison between the ophthalmologist and the nurse showed a kappa statistic of 0.42 for both eyes (P<0.001). The kappa statistic was 0.54 and 0.52 for right and left eyes respectively between the ophthalmologist and the non-professional health worker (P<0.001). As for agreement between the nurse and the non-professional health worker,the kappa statistic was 0.49 and 0.38 for right and left eyes,respectively (P<0.001). Conclusion The oblique flashlight test may be used as an applicable tool by trained community health workers for screening of shallow anterior chamber and play a role in blindness prevention in community. 展开更多
关键词 工作者 手电筒 卫生 社区 眼科 医生 测试 筛选
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Predictors for attending annual eye screening for diabetic retinopathy amongst patients with diabetes in an urban community of Beijing 被引量:1
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作者 yan-hong zou Qian Li +5 位作者 Shan-Shan Cui Wei Jia Ning Zhang Kai Ma Torkel Snellingen Xi-Pu Liu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第7期1144-1149,共6页
AIM: To gain a better understanding of possible factors that may influence the decision of diabetes persons to participate in annual eye screening in an urban community setting of China.METHODS: A structured intervi... AIM: To gain a better understanding of possible factors that may influence the decision of diabetes persons to participate in annual eye screening in an urban community setting of China.METHODS: A structured interview including questions on attendance of eye screening, knowledge and awareness of diabetic retinopathy was conducted. The presence and degree of retinopathy were assessed using two field nonmydriatic retinal photography. RESULTS: Totally 720 diabetes persons were recruited and 519 were enrolled in this cross-sectional study. In this urban setting of Beijing, among diabetes patients of average of 10 y duration, 77% confirmed having undergone at least one eye examination and 61% reported having at least one eye examination with dilated pupil. As for the last 12 mo, the number decreased to 210(47%) and 131(30%) separately. Most of the participants(95%) were aware that diabetes could affect their vision and that regular eye examination was necessary. Very few of them(12%) however were aware that the early stages of diabetic retinopathy presented without symptoms of vision loss. Having attended patient education on diabetes was effective in building awareness about diabetic eye disease and was a significant positive predictor for attending eye screening [education in a year, Adj. OR=0.47(0.29-0.74), P〈0.001, education years ago, Adj. OR=0.56(0.33-0.96), P=0.036]. The duration of disease also increasedthe likelihood of having undergone eye screening(Adj. OR=0.96, P〈0.05). CONCLUSION: Being exposed to education about the complications of diabetes increases the probability of attending diabetic eye screening. An appropriate patient knowledge building strategy should be made available to patients from the time of diagnosis. 展开更多
关键词 diabetic retinopathy annual screening education community
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