白藜芦醇及其衍生物在TNF-α诱导的人脐静脉内皮细胞中的抗炎作用

二苯乙烯类化合物，自1940年首次从毛藜芦根中分离出白藜芦醇以来就对此进行了广泛研究。这类化合物存在于许多植物中并具有广泛的生理活性，主要有抗氧化、抗肿瘤、抗淤血综合征（如脑炎、动脉粥样硬化、慢性炎症）等。白藜芦醇（trans-3，5，4’-trihydroxystiibene），是从中药虎杖中提取出来的一种二苯乙烯类化合物，同时也是一种非常重要的植物内毒素，在近年来的实验研究中已充分证明其具有很多有益的药理作用，如抗癌、心血管保护、神经保护、抗衰老和抗炎等等。大量研究证实其在抗动脉粥样硬化中起着非常重要的作用。近年来随着白藜芦醇的类似物的不断出现，研究者们发现其中一些二苯乙烯类化合物同样具有许多与白藜芦醇相似的药理活性且某些化合物的活性、选择性及稳定性均要强于白藜芦醇，故成为目前研究的热点。为了探讨白藜芦醇类似物中甲基化白藜芦醇和自藜芦醇苷的抗炎效应并阐明其作用机制，同时与白藜芦醇进行比较，我们首先用细胞黏附实验测定其是否具有抗细胞黏附的能力，然后对其相关的黏附分子的表达及NF—κB进行考察。

Strong light–matter interactions based on excitons and the abnormal all-dielectric anapole mode with both large field enhancement and low loss

The room temperature strong coupling between the photonic modes of micro/nanocavities and quantum emitters(QEs) can bring about promising advantages for fundamental and applied physics.Improving the electric fields(EFs) by using plasmonic modes and reducing their losses by applying dielectric nanocavities are widely employed approaches to achieve room temperature strong coupling.However,ideal photonic modes with both large EFs and low loss have been lacking.Herein,we propose the abnormal anapole mode (AAM),showing both a strong EF enhancement of~70-fold (comparable to plasmonic modes) and a low loss of 34 meV,which is much smaller than previous records of isolated all-dielectric nanocavities.Besides realizing strong coupling,we further show that by replacing the normal anapole mode with the AAM,the lasing threshold of the AAM-coupled QEs can be reduced by one order of magnitude,implying a vital step toward on-chip integration of nanophotonic devices.