Background and Aims:The hepatitis E virus(HEV)is a zoonotic disease,and infection with HEV in humans primarily causes acute infections and can progress to chronic manifestation in immunocompromised individuals.Over th...Background and Aims:The hepatitis E virus(HEV)is a zoonotic disease,and infection with HEV in humans primarily causes acute infections and can progress to chronic manifestation in immunocompromised individuals.Over the past decade,guidelines for diagnosing and treating HEV infection have been developed.This study aimed to systematically assess the quality of current guidelines for diagnosing and treating HEV infection,and we analyzed the differences in guideline quality and primary recommendations and explored possible reasons for these differences.Methods:Guidelines published between 2013 and 2022 were searched,and studies were identified using selection criteria.The study assessed the quality of the included guidelines using the Appraisal of Guidelines for Research and Evaluation tool,extracted the primary recommendations in the guidelines,determined the highest level of evidence supporting the recommendations,and reclassified the evidence using the Oxford Centre for Evidence-Based Medicine grading system.Results:Seven guidelines were included in the final analysis.The quality of the guidelines varied widely.The discrepancies may have been caused by the lack of external experts,the failure to consider influencing factors in guideline application,and the lack of consideration of the public’s opinion.Analysis of the heterogeneity in primary recommendations revealed differences in algorithms for managing chronic HEV infection,the dosage of ribavirin,and a low level of evidence supporting the primary recommendations.Conclusions:Guideline quality and primary recommendations vary considerably.Refinement by guideline developers and researchers would facilitate updating and applying guidelines for diagnosing and treating HEV infection.展开更多
基金supported by The National Natural Science Foundation of China(82360108 to YMT)Medicine Leading Talents of Yunnan Province(L-2019013 to YMT)+3 种基金The Yunnan Wanren Project(YNWR-MY-2018-028 to YMT)The Chen Jie Expert Workstation of Yunnan Province(202305AF150065 to YMT)Clinical Research Project of the Second Affiliated Hospital of Kunming Medical University(2020ynlc010,yn1IT2021017 to YMT)China Liver Health—Special project of prevention and treatment of hepatitis E(CLH2023-FHEV-08 to YMT).
文摘Background and Aims:The hepatitis E virus(HEV)is a zoonotic disease,and infection with HEV in humans primarily causes acute infections and can progress to chronic manifestation in immunocompromised individuals.Over the past decade,guidelines for diagnosing and treating HEV infection have been developed.This study aimed to systematically assess the quality of current guidelines for diagnosing and treating HEV infection,and we analyzed the differences in guideline quality and primary recommendations and explored possible reasons for these differences.Methods:Guidelines published between 2013 and 2022 were searched,and studies were identified using selection criteria.The study assessed the quality of the included guidelines using the Appraisal of Guidelines for Research and Evaluation tool,extracted the primary recommendations in the guidelines,determined the highest level of evidence supporting the recommendations,and reclassified the evidence using the Oxford Centre for Evidence-Based Medicine grading system.Results:Seven guidelines were included in the final analysis.The quality of the guidelines varied widely.The discrepancies may have been caused by the lack of external experts,the failure to consider influencing factors in guideline application,and the lack of consideration of the public’s opinion.Analysis of the heterogeneity in primary recommendations revealed differences in algorithms for managing chronic HEV infection,the dosage of ribavirin,and a low level of evidence supporting the primary recommendations.Conclusions:Guideline quality and primary recommendations vary considerably.Refinement by guideline developers and researchers would facilitate updating and applying guidelines for diagnosing and treating HEV infection.
