Human hepatocellular carcinoma(HCC)heavily endangers human heath worldwide.HCC is one of most frequent cancers in China because patients with liver disease,such as chronic hepatitis,have the highest cancer susceptibil...Human hepatocellular carcinoma(HCC)heavily endangers human heath worldwide.HCC is one of most frequent cancers in China because patients with liver disease,such as chronic hepatitis,have the highest cancer susceptibility.Traditional therapeutic approaches have limited efficacy in advanced liver cancer,and novel strategies are urgently needed to improve the limited treatment options for HCC.This review summarizes the basic knowledge,current advances,and future challenges and prospects of adeno-associated virus(AAV)and adenoviruses as vectors for gene therapy of HCC.This paper also reviews the clinical trials of gene therapy using adenovirus vectors,immunotherapy,toxicity and immunological barriers for AAV and adenoviruses,and proposes several alternative strategies to overcome the therapeutic barriers to using AAV and adenoviruses as vectors.展开更多
The development of functional nanocarriers with multifunctional ability and expected degradability is of great significance for efficient drug delivery on tumor therapy.The release of non-specific drugs and serious si...The development of functional nanocarriers with multifunctional ability and expected degradability is of great significance for efficient drug delivery on tumor therapy.The release of non-specific drugs and serious side effects severely limit their therapeutic effectiveness,although chemotherapy has been far and widely used in clinical practice[1-4].In the past few decades,nanosized drug carriers integrated with multi-responsive properties have emerged as promising candidates for anticancer treatment due to their long circulation in the bloodstream,high drug loading capacity,and“passive”targeting capability on account of the enhanced permeability and retention(EPR)effect[5-8].展开更多
基金Supported by National Natural Science Foundation of China.No.81272687Zhejiang Provincial Public Welfare Technology Application Research Projects,No.2014C33275+1 种基金Zhejiang Provincial Natural Science Foundation of China,No.LZ13H160004the Grant for 521 Talent Project of Zhejiang Sci-Tech University,Hangzhou,China
文摘Human hepatocellular carcinoma(HCC)heavily endangers human heath worldwide.HCC is one of most frequent cancers in China because patients with liver disease,such as chronic hepatitis,have the highest cancer susceptibility.Traditional therapeutic approaches have limited efficacy in advanced liver cancer,and novel strategies are urgently needed to improve the limited treatment options for HCC.This review summarizes the basic knowledge,current advances,and future challenges and prospects of adeno-associated virus(AAV)and adenoviruses as vectors for gene therapy of HCC.This paper also reviews the clinical trials of gene therapy using adenovirus vectors,immunotherapy,toxicity and immunological barriers for AAV and adenoviruses,and proposes several alternative strategies to overcome the therapeutic barriers to using AAV and adenoviruses as vectors.
文摘The development of functional nanocarriers with multifunctional ability and expected degradability is of great significance for efficient drug delivery on tumor therapy.The release of non-specific drugs and serious side effects severely limit their therapeutic effectiveness,although chemotherapy has been far and widely used in clinical practice[1-4].In the past few decades,nanosized drug carriers integrated with multi-responsive properties have emerged as promising candidates for anticancer treatment due to their long circulation in the bloodstream,high drug loading capacity,and“passive”targeting capability on account of the enhanced permeability and retention(EPR)effect[5-8].
