Impact of early refined nursing program on prognosis of middleaged and elderly patients with cognitive dysfunction combined with cerebral infarction

BACKGROUND Cerebral infarction is a local or extensive necrosis of brain tissue.Subsequently,the corresponding neurological deficits appear.The incidence of cerebrovascular diseases in China is increasing gradually.After the onset of cerebrovascular disease,the most common sequelae include movement disorders,language disorders,and cognitive dysfunction.AIM To investigate the effect of early refined nursing program on the prognosis of middle-aged and elderly patients with cerebral infarction combined with cognitive dysfunction.METHODS A retrospective study was conducted to divide 60 patients with cerebral infarction and cognitive impairment into an experimental group(n=32)and a control group(n=28).The experimental group received early intensive care every day,and the control group received daily routine care.The scores of the Mini-Mental State Examination(MMSE)and the Trail Making Test(TMT),as well as the latency and amplitude of the event-related potential P300,were used as main indicators to evaluate changes in cognitive function,and changes in BDNF,TGF-β,and GDNF expression were used as secondary indicators.RESULTS Both groups experienced notable enhancements in MMSE scores,with the experi-mental group demonstrating higher scores than the control group(experimental:28.75±2.31;control:25.84±2.87).Moreover,reductions in TMT-A and TMT-B scores were observed in both groups(experimental:TMT-A 52.36±6.18,TMT-B 98.47±10.23;control:TMT-A 61.48±7.92,TMT-B 112.63±12.55),with the experimental group displaying lower scores.P300 Latency decreased(experimental:270.63 ms±14.28 ms;control:285.72 ms±16.45 ms),while amplitude increased(experimental:7.82μV±1.05μV;control:6.35μV±0.98μV)significantly in both groups,with superior outcomes in the experimental cohort.Additionally,the levels of the growth factors BDNF,TGF-β1,and GDNF surged(experimental:BDNF 48.37 ng/mL±5.62 ng/mL,TGF-β152.14 pg/mL±4.28 pg/mL,GDNF 34.76 ng/mL±3.89 ng/mL;control:BDNF 42.58 ng/mL±4.73 ng/mL,TGF-β146.23 pg/mL±3.94 pg/mL,GDNF 30.25 ng/mL±2.98 ng/mL)in both groups,with higher levels in the experimental group.CONCLUSION For middle-aged and elderly patients with cerebral infarction and cognitive dysfunction,early refined nursing can significantly improve their cognitive function and prognosis.

Preliminary study on detection and cleaning of parasitic bunches

To establish a nuclear resonant scattering beamline at the High Energy Photon Source(HEPS),it is essential to develop tools for detection and cleaning of parasitic bunches,for meeting the stringent demands on bunch purity.To this end,a novel time-correlated single-photon counting system was implemented at the electron storage ring of the Beijing Electron–Positron Collider II(BEPCII).The purity deterioration process over a week-long operation was recorded by the system.In this study,the mechanism of impurity growth was analyzed by numerical methods and validated on measurements.The agreement between the experimental results and the cal-culation was fairly good.Two main sources of parasitic bunches,pre-accelerators and the Touschek scattering were confirmed.A bunch-cleaning technique,based on a sinu-soidal signal mixed with a pseudo-square wave,was also developed and implemented,and its capability to improve the bunch purity to the level of 10–7 was experimentally demonstrated.We present the experimental setup,princi-ple,and measurement results of a system for detection and cleaning of parasitic bunches.

A high sensitivity tune measurement system for BEPCII

Background The tune is one of the most important parameters of the storage ring which play a crucial role in the brightness optimization.The synchrotron radiation will suppress the oscillation and make the detection unusual difficulty without any kicker excitation.Purpose A new high sensitivity tune measurement system is developed to show the real-time tune during the colliding.Method Peak diode detectors are used to convert short beam pulses from a button BPM into slowly varying signals.Their DC components,constituting a large background related to beam offsets,are suppressed by series capacitors,while the small signals related to beam oscillations are passed to the subsequent stages for amplification and filtering.Conclusion A direct diode detection technique based on the diode peak hold circuit could increase the sensitivity by hundreds time which gets a clearly tune peak even with synchrotron radiation and bunch-by-bunch feedback damping.