Numerous dark enclaves with different shapes are found in Jiuling Neoproterozoic granitoids.Precise LAICP-MS U-Pb dating was conducted on zircons extracted from two microcrystalline enclave samples,yielding crystalliz...Numerous dark enclaves with different shapes are found in Jiuling Neoproterozoic granitoids.Precise LAICP-MS U-Pb dating was conducted on zircons extracted from two microcrystalline enclave samples,yielding crystallization ages of 822.6±5.8 Ma and 822.2±6.2 Ma,respectively.The consistent ages within analytical errors with the host granitoids suggested that they were the products of the same magmatism.The microcrystalline-dioritic enclaves commonly show plastic forms and contain similar plagioclase megacrysts to the host rocks,and both of the enclaves and host granitoids showed a complex composition and structural imbalance in plagioclases.Furthermore,the apatites with a euhedral acicular shape occurred widely in the microcrystalline-dioritic enclaves.All of these petrographic features above imply magma mixing is involved in their diagenesis.The enclaves and host granitoids show a marked zircon trace element difference and Hf isotopic signatures without correlation in zircon trace element pairs but form their own system between enclaves and host granitoids.Additionally,most of the zircons show extremely high εHf (t) with εHf (t) =3.54?11.94 from the southern samples,and εHf (t) =1.0?9.09 from the central region.Some zircons with the higher εHf (t) are similar to the zircons from the juvenile island arc in the eastern segment of Jiangnan Orogen.Integrated geological and Hf isotopic characteristics suggest microcrystalline-dioritic enclaves were derived from the partial melting process of the Mesoproterozoic crust which enriched juvenile island arc materials and mixed with the granitic magma that remelted from the Mesoproterozoic continental crust which relatively enriched ancient sediments and mixed with the host granitoid in diagenesis.展开更多
The structure–activity relationship（SAR） study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a（hGRa） antagonists is reported.Compounds were screened using hydroxyapati...The structure–activity relationship（SAR） study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a（hGRa） antagonists is reported.Compounds were screened using hydroxyapatite-based GR binding and MMTV-Luc co-transfection reporter gene assays.Four different regions of the scaffold were modified to assess the effects on hGRa antagonism and related potency.Compound 8d exhibits an 8-fold better bioactivity than the original hit 1a,as well as an improved chemical stability,which make it a promising lead for the subsequent optimization.展开更多
基金2018 Xiamen Medical and Health Project(Guiding Project)(No. 3502Z20189046)2020 Xiamen Medical and Health Project (Guiding Project)(No.3502Z20209224)。
文摘Numerous dark enclaves with different shapes are found in Jiuling Neoproterozoic granitoids.Precise LAICP-MS U-Pb dating was conducted on zircons extracted from two microcrystalline enclave samples,yielding crystallization ages of 822.6±5.8 Ma and 822.2±6.2 Ma,respectively.The consistent ages within analytical errors with the host granitoids suggested that they were the products of the same magmatism.The microcrystalline-dioritic enclaves commonly show plastic forms and contain similar plagioclase megacrysts to the host rocks,and both of the enclaves and host granitoids showed a complex composition and structural imbalance in plagioclases.Furthermore,the apatites with a euhedral acicular shape occurred widely in the microcrystalline-dioritic enclaves.All of these petrographic features above imply magma mixing is involved in their diagenesis.The enclaves and host granitoids show a marked zircon trace element difference and Hf isotopic signatures without correlation in zircon trace element pairs but form their own system between enclaves and host granitoids.Additionally,most of the zircons show extremely high εHf (t) with εHf (t) =3.54?11.94 from the southern samples,and εHf (t) =1.0?9.09 from the central region.Some zircons with the higher εHf (t) are similar to the zircons from the juvenile island arc in the eastern segment of Jiangnan Orogen.Integrated geological and Hf isotopic characteristics suggest microcrystalline-dioritic enclaves were derived from the partial melting process of the Mesoproterozoic crust which enriched juvenile island arc materials and mixed with the granitic magma that remelted from the Mesoproterozoic continental crust which relatively enriched ancient sediments and mixed with the host granitoid in diagenesis.
基金supported in part by grants from the Ministry of Health of China (Nos. 2012ZX09304-011, 2013ZX09401003-005, 2013ZX09507001 and 2013ZX09507002)Shanghai Science and Technology Development Fund (No. 13DZ2290300)Thousand Talents Program in China
文摘The structure–activity relationship（SAR） study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a（hGRa） antagonists is reported.Compounds were screened using hydroxyapatite-based GR binding and MMTV-Luc co-transfection reporter gene assays.Four different regions of the scaffold were modified to assess the effects on hGRa antagonism and related potency.Compound 8d exhibits an 8-fold better bioactivity than the original hit 1a,as well as an improved chemical stability,which make it a promising lead for the subsequent optimization.
