Clinically significant endoscopic findings in patients of dyspepsia with no warning symptoms:A cross-sectional study

BACKGROUND Dyspepsia is one of the commonest clinical disorder.However,controversy remains over the role of endoscopy in patients with dyspepsia.No studies have evaluated the diagnostic value of endoscopy in patients with no warning symptoms according to the Rome IV criteria.AIM To study the diagnostic value of endoscopy in dyspeptic patients with no warning symptoms.METHODS This cross-sectional study included dyspeptic patients with no warning symptoms who met the inclusion and exclusion criteria at The First Affiliated Hospital,Zhejiang Chinese Medical University from April 2018 to February 2019.The clinical data were collected using questionnaires,including dyspeptic information,warning symptoms,other diseases,family history and basic demographic data.Based on dyspeptic symptoms,patients can be divided into epigastric pain syndrome,postprandial distress syndrome or overlapping subtypes.RESULTS A total of 1016 cases were enrolled,304(29.9%)had clinically significant findings that were detectable by endoscopy.The endoscopy findings included esophageal lesions in 180(17.7%)cases,peptic ulcers in 115(11.3%)cases and malignancy in 9(0.89%)patients.Multivariate logistic regression analysis showed that males[odds ratio(OR)=1.758,P<0.001],body mass index>25(OR=1.660;P=0.005),epigastric pain(OR=1.423;P=0.019)and Helicobacter pylori infection(OR=1.949;P<0.001)were independently associated with risk factors for the presence of clinically significant findings on endoscopy.CONCLUSION Chinese patients with dyspepsia with no warning symptoms should undergo endoscopy,particularly males,patients with body mass index>25,epigastric pain or Helicobacter pylori infection.

Emerging relationship between RNA helicases and autophagy

RNA helicases,the largest family of proteins that participate in RNA metabolism,stabilize the intracellular environment through various processes,such as translation and pre-RNA splicing.These proteins are also involved in some diseases,such as cancers and viral diseases.Autophagy,a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival,is associated with human diseases.Interestingly,similar to autophagy,RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases.According to recent studies,RNA helicases are closely related to autophagy,participate in regulating autophagy,or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progress!on of diseases.Here,we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases.