Spectral properties of Pr:CNGG crystals grown by micro-pulling-down method

Pr^3+-doped calcium niobium gallium garnet(Pr:CNGG)single crystals with different Pr^3+concentrations are successfully grown by the micro-pulling-down(μ-PD)method.The crystal structure,room-temperature absorption spectra,and fluorescence spectra of Pr:CNGG crystals are measured and discussed.The fluorescence results indicate their large dependence on the doping concentration.The fluorescence lifetime of the 1D2 energy level is also determined.The results indicate that Pr:CNGG crystal could be a potential solid-state laser gain medium.

Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic biomarkers.More ADspecific early diagnostic and disease staging biomarkers are needed.In this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 participants.Candidate biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 participants.We quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,respectively.In the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,respectively.Separate 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,respectively.The 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative diseases.Moreover,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD stages.Our findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

Lattices Generated by Joins of the Flats in Orbits under Finite Affine-singular Symplectic Group and its Characteristic Polynomials

Let ASG（2v ＋ l, v; Fq） be the （2v ＋l）-dimensional affine-singular symplectic space over the finite field Fq and ASp2v＋l,v（Fq） be the affine-singular symplectic group of degree 2v ＋ l over Fq. Let O be any orbit of flats under ASp2v＋l,v（Fq）. Denote by J the set of all flats which are joins of flats in O such that O LJ and assume the join of the empty set of flats in ASG（2v ＋ l, v;Fq） is φ. Ordering LJ by ordinary or reverse inclusion, then two lattices axe obtained. This paper firstly studies the inclusion relations between different lattices, then determines a characterization of flats contained in a given lattice LJ, when the lattices form geometric lattice, lastly gives the characteristic polynomial of LJ.