A new furostanoside, aspafilioside D (1) has been isolated from the root of Asparagus filicinus. Its structure was determined by spectral and chemical methods.
OBJECTIVE Ovarian dysgerminoma is an uncommon ovarian malignancy. Its clinical features are special and there are many factors affecting its prognosis. If treated properly, the patient can be cured. Otherwise it may e...OBJECTIVE Ovarian dysgerminoma is an uncommon ovarian malignancy. Its clinical features are special and there are many factors affecting its prognosis. If treated properly, the patient can be cured. Otherwise it may endanger the patient's life. The aim of this study is to investigate the clinical features and factors related to prognosis of ovarian dysgerminoma. METHODS Data from 57 patients with pure ovarian dysgerminoma were analyzed retrospectively. The patients were admitted to the Cancer Center, Sun Yat-sen University from January 1,1964 to December 31,2000. RESULTS The main clinical features were abdominal mass (56.1%), abdominal pain (21.1%), abdominal swelling (17.5%), vaginal bleeding (5.3%)and genital tract abnormalities (5.3%). Twenty-six patients had stage Ⅰ diseases,8 stage Ⅱ,9 stage Ⅲ,1 stage Ⅳ and 13 recurrent and persistent diseases. The uterus was involved in 41.2% of patients with stage Ⅱ-Ⅲ diseases. Combined modality was given to 52 cases and a singlemethod treatment to 5 cases. The total overall 5 and 10-year survival rates for stages Ⅰ-Ⅳ was 80.1% and 70.0% respectively. The 5-year survival rate for stage Ⅰ was 100%, stage Ⅱ 55.2% ,stage Ⅲ 55.6% and stage Ⅳ 0% ; for recurrent and persistent diseases, 72.7%. The stage I group of 12 patients received adnexectomy and 14 patients underwent hysterectomy and adnexa removal. There was no significant difference between the 5 and 10-year survival rates (all 100%). Of the 23 patients in the stage Ⅰ group to whomonly chemotherapy was given after operation, 19 cases received 3 or morecourses and were well without recurrence; 4 patients received only onecourse and one of them recurred 21 months after the operation. In the group of stages Ⅱ and Ⅲ cases, the 5-year survival rate was 86.7% for those whose chemotherapy courses were t> 4 and 25.0% for patients who received less than 4 courses of chemotherapy (P<0.05). CONCLUSIONS The prognosis of ovarian dysgerminoma is closely related to the disease stage and treatment modality. A fertility-preserving operation can be considered in early-staged patients, but caution needs to be exercised in the middle to late staged cases. Good results can be achieved with an operation-based combined modality in recurrent patients.展开更多
基金This work was supported by the National Natural Science Fundation of China (30100229) and Science and Technology Development Fundation of Shanghai China (01QB14051) and these supports are gratefully acknowledged.
文摘A new furostanoside, aspafilioside D (1) has been isolated from the root of Asparagus filicinus. Its structure was determined by spectral and chemical methods.
文摘OBJECTIVE Ovarian dysgerminoma is an uncommon ovarian malignancy. Its clinical features are special and there are many factors affecting its prognosis. If treated properly, the patient can be cured. Otherwise it may endanger the patient's life. The aim of this study is to investigate the clinical features and factors related to prognosis of ovarian dysgerminoma. METHODS Data from 57 patients with pure ovarian dysgerminoma were analyzed retrospectively. The patients were admitted to the Cancer Center, Sun Yat-sen University from January 1,1964 to December 31,2000. RESULTS The main clinical features were abdominal mass (56.1%), abdominal pain (21.1%), abdominal swelling (17.5%), vaginal bleeding (5.3%)and genital tract abnormalities (5.3%). Twenty-six patients had stage Ⅰ diseases,8 stage Ⅱ,9 stage Ⅲ,1 stage Ⅳ and 13 recurrent and persistent diseases. The uterus was involved in 41.2% of patients with stage Ⅱ-Ⅲ diseases. Combined modality was given to 52 cases and a singlemethod treatment to 5 cases. The total overall 5 and 10-year survival rates for stages Ⅰ-Ⅳ was 80.1% and 70.0% respectively. The 5-year survival rate for stage Ⅰ was 100%, stage Ⅱ 55.2% ,stage Ⅲ 55.6% and stage Ⅳ 0% ; for recurrent and persistent diseases, 72.7%. The stage I group of 12 patients received adnexectomy and 14 patients underwent hysterectomy and adnexa removal. There was no significant difference between the 5 and 10-year survival rates (all 100%). Of the 23 patients in the stage Ⅰ group to whomonly chemotherapy was given after operation, 19 cases received 3 or morecourses and were well without recurrence; 4 patients received only onecourse and one of them recurred 21 months after the operation. In the group of stages Ⅱ and Ⅲ cases, the 5-year survival rate was 86.7% for those whose chemotherapy courses were t> 4 and 25.0% for patients who received less than 4 courses of chemotherapy (P<0.05). CONCLUSIONS The prognosis of ovarian dysgerminoma is closely related to the disease stage and treatment modality. A fertility-preserving operation can be considered in early-staged patients, but caution needs to be exercised in the middle to late staged cases. Good results can be achieved with an operation-based combined modality in recurrent patients.
