Intelligent Immunity Based Security Defense System for Multi-Access Edge Computing Network

In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to protect the security of whole system.In the proposed security defense system,the security is protected by the intelligent immunity through three functions,identification function,learning function,and regulation function,respectively.Meanwhile,a three process-based intelligent algorithm is proposed for the intelligent immunity system.Numerical simulations are given to prove the effeteness of the proposed approach.

Aeolian processes on sandy desertification of an alpine meadow: A wind tunnel experiment

In recent years,the desertification of alpine meadows has become a serious ecological problem and has gradually become a threat to regional economic activities in Maqu County.To reveal the mechanism for sandy desertification of alpine meadows,we conducted wind tunnel experiments on aeolian processes over sandy alpine meadows.Results show that the sandflux profile of mix-sized sediment decays exponentially with increasing height.However,the profile pattern of a group of uniform-sized particles depends on the experimental wind speeds.The profile pattern of all the groups studied can be expressed by exponential decay functions when the wind speed is less than or equal to 16 m/s.while that for all the groups studied can be expressed by a Gaussian distribution function when the wind speed is above 16 m/s.The average saltation heights of mixed sands at wind speeds of 12 m/s,16 m/s,20 m/s,and 24 m/s were 2.74,4.19,5.28,and 6.12 cm,respectively.The mean grain size basically first decreases and then increases with increasing height under different wind speeds.The sorting improves with increasing wind speed,while the kurtosis and skewness show relationships with only the characteristics of the parent soil.

Aberrantly high activation of a FoxM1-STMN1 axis contributes to progression and tumorigenesis in FoxMl-driven cancers

Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-binding protein which can inhibit the assembly of microtubule dimer or promote depolymerization of microtubules.It was reported as a major responsive factor of paclitaxel resistance for clinical chemotherapy of tumor patients.But the function of abnormally high level of STMN1 and its regulation mechanism in cancer cells remain unclear.In this study,we used public database and tissue microarrays to analyze the expression pattern of FoxM1 and STMN1 and found a strong positive correlation between FoxM1 and STMN1 in multiple types of cancer.Lentivirus-mediated FoxM1/STMN1-knockdown cell lines were established to study the function of FoxM1/STMN1 by performing cell viability assay,plate clone formation assay,soft agar assay in vitro and xenograft mouse model in vivo.Our results showed that FoxMl promotes cell proliferation by upregulating STMN1.Further ChIP assay showed that FoxM1 upregulates STMN1 in a transcriptional level.Prognostic analysis showed that a high level of FoxM1 and STMN1 is related to poor prognosis in solid tumors.Moreover,a high co-expression of FoxM1 and STMN1 has a more significant correlation with poor prognosis.Our findings suggest that a general FoxMl-STMN1 axis contributes to cell proliferation and tumorigenesis in hepatocellular carcinoma,gastric cancer and colorectal cancer.The combination of FoxM1 and STMN1 can be a more precise biomarker for prognostic prediction.