The aramid fiber礥HMWPE (ultrahigh molecular weight polyethylene) fiber hybrid composites (AF礑F) were ma-nufactured. By Charpy impact, the low velocity impact behavior of AF礑F composite was studied. And the high vel...The aramid fiber礥HMWPE (ultrahigh molecular weight polyethylene) fiber hybrid composites (AF礑F) were ma-nufactured. By Charpy impact, the low velocity impact behavior of AF礑F composite was studied. And the high velocity impact behavior under ballistic impact was also investigated. The influence of hybrid ratio on the performances of low and high velocity impact was analyzed, and hybrid structures with good impact properties under low velocity impact and high velocity were optimized. For Charpy impact, the maximal impact load increased with the accretion of the AF layers for AF礑F hybrid composites. The total impact power was reduced with the decrease of DF layers and the delamination can result in the increase of total impact power. For ballistic impact, the DF ballistic performance was better than that of the AF and the hybrid ratio had a crucial influence. The failure morphology of AF礑F hybrid composite under Charpy impact and ballistic impact was analyzed. The AF礑F hybrid composites in suitable hybrid ratio could attain better performance than AF or DF composites.展开更多
OBJECTIVE Diabetic peripheral neuropathy(DPN)is the cause of considerable morbidity and mortality indiabetic patients.The loss of nerve fibersis the main pathological characteristics of the DPN and the pathway of Oct6...OBJECTIVE Diabetic peripheral neuropathy(DPN)is the cause of considerable morbidity and mortality indiabetic patients.The loss of nerve fibersis the main pathological characteristics of the DPN and the pathway of Oct6-Krox20 plays an important role in the formation of myelin sheath.In our previous study,we found that Fuzi(Radix aconite lateral ispreparata)could significantly improve the nerve conduction deficits and thermal hypoalgesia deficits in the diabetic rats,but the underlying molecular mechanisms have not been established.The aim of this study is to investigate the expression of Oct6,Krox20,myelin basic protein(Mbp)and myelin protein zero(Mpz)in Schwann cells and analyze the effect of Fuzi in the formation of myelin sheath.METHODS There were six groups in the study.In the control group,thecells weresupplemented with normal cell culture medium.In the mannitol group,the cells were fed with normal glucose plus mannitol.In the model group,the cells were supplemented with high glucose medium(75 mmol·L-1).In the other group,the cells weretreated with high glucose medium(75mmol·L-1)plus different concentrations of Fuzi(0.1,1.0 and 10.0μg·mL-1).After three days,real-time PCR was used to detect gene expression.RESULTS Compared with the control group,the model group showed lowerexpression of Oct6,Krox20,Mbp and Mpz.In comparison to the model group,Fuzi(0.1,1.0and 10.0μg·mL-1)increased the expression of Oct6,Krox20,Mbp and Mpz.CONCLUSION These results demonstrate that Fuzi enhances the protein of myelin sheath through impacting the pathway of Oct6-Krox20.展开更多
文摘The aramid fiber礥HMWPE (ultrahigh molecular weight polyethylene) fiber hybrid composites (AF礑F) were ma-nufactured. By Charpy impact, the low velocity impact behavior of AF礑F composite was studied. And the high velocity impact behavior under ballistic impact was also investigated. The influence of hybrid ratio on the performances of low and high velocity impact was analyzed, and hybrid structures with good impact properties under low velocity impact and high velocity were optimized. For Charpy impact, the maximal impact load increased with the accretion of the AF layers for AF礑F hybrid composites. The total impact power was reduced with the decrease of DF layers and the delamination can result in the increase of total impact power. For ballistic impact, the DF ballistic performance was better than that of the AF and the hybrid ratio had a crucial influence. The failure morphology of AF礑F hybrid composite under Charpy impact and ballistic impact was analyzed. The AF礑F hybrid composites in suitable hybrid ratio could attain better performance than AF or DF composites.
文摘OBJECTIVE Diabetic peripheral neuropathy(DPN)is the cause of considerable morbidity and mortality indiabetic patients.The loss of nerve fibersis the main pathological characteristics of the DPN and the pathway of Oct6-Krox20 plays an important role in the formation of myelin sheath.In our previous study,we found that Fuzi(Radix aconite lateral ispreparata)could significantly improve the nerve conduction deficits and thermal hypoalgesia deficits in the diabetic rats,but the underlying molecular mechanisms have not been established.The aim of this study is to investigate the expression of Oct6,Krox20,myelin basic protein(Mbp)and myelin protein zero(Mpz)in Schwann cells and analyze the effect of Fuzi in the formation of myelin sheath.METHODS There were six groups in the study.In the control group,thecells weresupplemented with normal cell culture medium.In the mannitol group,the cells were fed with normal glucose plus mannitol.In the model group,the cells were supplemented with high glucose medium(75 mmol·L-1).In the other group,the cells weretreated with high glucose medium(75mmol·L-1)plus different concentrations of Fuzi(0.1,1.0 and 10.0μg·mL-1).After three days,real-time PCR was used to detect gene expression.RESULTS Compared with the control group,the model group showed lowerexpression of Oct6,Krox20,Mbp and Mpz.In comparison to the model group,Fuzi(0.1,1.0and 10.0μg·mL-1)increased the expression of Oct6,Krox20,Mbp and Mpz.CONCLUSION These results demonstrate that Fuzi enhances the protein of myelin sheath through impacting the pathway of Oct6-Krox20.
