Gas Phase Hydrogenated and Deuterated Fullerene Cations

H/D accretion,especially onto ionized fullerenes,is expected to be very efficient in space.In this work,we study hydrogenated and deuterated fullerene cations and their photodissociation behavior in the gas phase.The experimental results show that hydrogenated fullerene cations(i.e.,[C_(60)H_(n)]^(+)and[C_(70)H_(n)]^(+),n up to 30)and deuterated fullerene cations(i.e.,[C_(60)D_(n)]^(+)and[C_(70)D_(n)]^(+),n up to 21)are formed efficiently through the ion-atom collision reaction pathway.Upon irradiation,the hydrogenated and deuterated fullerene cations dissociate into fullerene cations and H/H_(2)or D/D_(2)species.The structures of the newly formed hydrogenated and deuterated fullerene cations(C_(58)and C_(60))and the bonding energies for these reaction pathways are investigated by means of quantum chemical calculations.The competition between hydrogenation and dehydrogenation is confirmed,and the hydrogenation-to-dehydrogenation ratio in the accretion processes in the gas phase is determined.We infer that the proportion of accreted hydrogen and deuterium atoms on the surface of fullerenes is similar to that of hydrogen and deuterium atoms in the interstellar environment where these fullerenes are located,especially when the interstellar environments are similar to our experimental conditions,i.e.,the hot environment.

烷基硅烷自组装中空纤维膜及膜蒸馏脱盐性能

采用浸没沉积法,借助浸没液中聚偏二氟乙烯(PVDF)的黏结性,将纳米SiO_(2)沉积在膜表面。利用SiO_(2)表面的硅羟基与十八烷基三甲氧基硅烷(OTMS)水解后的硅羟基进行自组装反应,制备了超疏水膜蒸馏用膜。研究了浸没液中PVDF浓度、SiO_(2)含量对膜性能的影响。当PVDF的质量分数为0.3%、纳米SiO_(2)质量分数为0.5%时,改性膜的性能最佳,扫描电镜结果表明,膜表面由PVDF微晶和纳米SiO_(2)组成了多孔连续粗糙结构,接触角达到156.5°,经过180 min超声处理和48 h强碱浸泡,膜表面依然具有超疏水性能。在NaCl和十二烷基硫酸钠(SDS)混合溶液、NaCl和腐殖酸(HA)混合溶液的DCMD测试中,改性膜具有稳定的通量和截留,而原膜在污染物SDS和HA的影响下,通量和截留下降,改性膜具有良好的抗润湿性能和抗污染性能。

Effect of etoposide plus thalidomide as maintenance therapy on progression-free survival of elderly patients with advanced non-small cell lung cancer

Objective The aim of the study was to evaluate the efficacy and safety of etoposide plus thalidomide as maintenance therapy for elderly patients with advanced non-small cell lung cancer(NSCLC) without disease progression after first-line chemotherapy.Methods After four to six cycles of platinum-based first-line therapy, 64 elderly patients with advanced NSCLC without disease progression who were treated in the General Hospital of Shenyang Military Region(China) from 2014 to 2016 were enrolled in this study. According to the different maintenance treatment methods, patients were divided as having received etoposide plus thalidomide therapy(treatment group, n = 32) and best supportive care(control group, n = 32). Disease control and progression-free survival(PFS) were compared between the two groups. Results The recent curative effect objective response rates of the treatment group and the control group were 31.3% and 3.1%, respectively, and the disease control rates were 71.9% and 31.3%, respectively. The Kaplan-Meier survival curves of the two groups were significantly different(χ2 = 26.532, P = 0.001). The median PFS for the treatment group and control group was 6.0 months [95% confidence interval(CI) = 4.3–7.9 months] and 3.2 months(95% CI = 2.6–3.8 months), respectively. The side effects in the treatment group included hematologic abnormalities, gastrointestinal toxicity, and impaired liver function, which were relieved after symptomatic support therapy and drug withdrawal.Conclusion Etoposide plus thalidomide as maintenance therapy is associated with a significantly longer PFS with tolerable toxicity for elderly patients with advanced NSCLC.

依托泊苷胶囊联合顺铂或卡铂治疗老年小细胞肺癌的临床观察(英文)

Objective: We aimed to explore the efficacy and safety of etoposide capsule combined with cisplatin or carboplatin in the treatment of elderly patients with small cell lung cancer(SCLC). Methods: From October 2011 to November 2013, 32 elderly patients(71–79 years old) with histopathologically confirmed SCLC in General Hospital of Shenyang Military Region(China) were enrolled in the research. The patients were administrated with lastet capsule 150–175 mg, d1–5, combined with cisplatin 20 mg/m2 d1–3 or carboplatin AUC = 5, applied over 2 days. Twenty-one days were 1 treatment cycle. Results: After treatments, 2 cases acquired complete response(CR), 19 cases acquired partial response(PR), 8 cases acquired stable disease(SD), and 3 cases had progression of disease(PD). The objective response rate was 65.6%(21/32), disease control rate was 90.6%(29/32). The median time of progression-free survival(PFS) was 6.9 months, the median survival time was 14.0 months, and 1 year survival rate was 62.4%. The main adverse reactions of I/II leukopenia and gastrointestinal reaction were observed. Conclusion: Etoposide capsule combined with cisplatin or carboplatin therapy have curative effect and good tolerance in elderly patients with SCLC.

Issues concerning "Greenification" of Green Food Enterprises

We redefine "green food enterprises" and expound the connotation of "greenification" of food processing industry. Taking the case of Heilongjiang Province, we give an overview of green food enterprises in Heilongjiang Province, and study the degree of "greenification" of food processing industry in Heilongjiang Province, through the case study of related enterprises. There are some problems in the process of pushing forward "greenification" of food processing industry, such as the high cost of production, varying quality of products, weak R & D capability and the distance limitations of raw material places and the consumer market. The following recommendations are put forth for promoting the "greenification" of food enterprises: (i) Reducing the production costs of green food, and improving the "greenification rate"; (ii) Intensifying policy support, and creating a "green" environment; (iii) Strengthening quality control, and improving consumers trust in green food; (iv) Establishing the network of green marketing, and broadening sales channels of green food.