Objective:To identify women vulnerable to substance use and self-medication during pregnancy based on associations with socio-demographic data.Methods:Data were collected in person,with self-developed questionnaires,f...Objective:To identify women vulnerable to substance use and self-medication during pregnancy based on associations with socio-demographic data.Methods:Data were collected in person,with self-developed questionnaires,from pregnant women(n=422)in Chengdu,China,from July to November 2012.Multivariate logistic regression analysis was used to reveal associations with socio-demographic parameters.Results:Higher educational background,being employed,and higher educational background of the mother were associated with a 37%[odds ratio(OR):0.63,95%CI:0.45-0.89],65%(OR:0.35,95%CI:0.13-0.94),and 29%(OR:0.71,95%CI:0.53-0.96)less likelihood of alcohol use,respectively.Adverse pregnancy outcome was associated with a 2.13-fold(OR:2.13,95%CI:1.07-4.25)greater likelihood of alcohol use.Young age and higher educational background were associated with an 11%(OR:0.89,95%CI:0.81-0.98)and 31%(OR:0.69,95%CI:0.49-0.98)less likelihood of cigarette smoking,respectively.Conclusion:Socio-demographic parameters were associated with substance use during pregnancy and warrants targeted health education provided by nurses to pregnant women.展开更多
Microbial enzymes are crucial for material biotransformation during the composting process.In this study,we investigated the effects of adding bamboo charcoal(BC)(i.e.,at 5%,10%,and 20%corresponding to BC5,BC10,and BC...Microbial enzymes are crucial for material biotransformation during the composting process.In this study,we investigated the effects of adding bamboo charcoal(BC)(i.e.,at 5%,10%,and 20%corresponding to BC5,BC10,and BC20,respectively)on the enzyme activity levels during chicken manure composting.The results showed that BC10 could increase the cellulose and urease activities by 56%and 96%,respectively.The bacterial community structure in BC10 differed from those in the other treatments,and Luteivirga,Lactobacillus,Paenalcaligenes,Ulvibacter,Bacillus,Facklamia,Pelagibacterium,Sporosarcina,Cellvibrio,and Corynebacterium had the most important roles in composting.Compared with other treatments,BC10 significantly enhanced the average rates of degradation of carbohydrates(Dxylose(40%)andα-D-lactose(44%))and amino acids(L-arginine(16%),L-asparagine(14%),and L-threonine(52%)).We also explored the associations among the bacterial community and their metabolic functions with the changes in the activities of enzymes.Network analysis demonstrated that BC10 altered the co-occurrence patterns of the bacterial communities,where Ulvibacter and class Bacilli were the keystone bacterial taxa with high capacities for degrading carbon source,and they were related to increases in the activities of cellulase and urease,respectively.The results obtained in this study may help to further enhance the efficiency of composting.展开更多
The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer.The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid prol...The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer.The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells.The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pathways whose activation sustains cancer growth.Unsurprisingly,it is also one of the most commonly attempted targets for cancer therapy.FK506 binding protein 8(FKBP8)is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptotic function.We aimed to explain these contradictory aspects of FKBP8 in cancer by identifying a“switch”type regulator.We identified through immunoprecipitation--mass spectrometry-based proteomic analysis that the mitochondrial protein prohibitin 1(PHB1)specifically interacts with FKBP8.Furthermore,the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway,whereas the FKBP8 level in the mitochondria was substantially reduced.Moreover,concomitant with these changes,the interaction between FKBP8 and mTOR substantially increased in the absence of PHB1.Collectively,our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular localization and mTOR regulating role.展开更多
文摘Objective:To identify women vulnerable to substance use and self-medication during pregnancy based on associations with socio-demographic data.Methods:Data were collected in person,with self-developed questionnaires,from pregnant women(n=422)in Chengdu,China,from July to November 2012.Multivariate logistic regression analysis was used to reveal associations with socio-demographic parameters.Results:Higher educational background,being employed,and higher educational background of the mother were associated with a 37%[odds ratio(OR):0.63,95%CI:0.45-0.89],65%(OR:0.35,95%CI:0.13-0.94),and 29%(OR:0.71,95%CI:0.53-0.96)less likelihood of alcohol use,respectively.Adverse pregnancy outcome was associated with a 2.13-fold(OR:2.13,95%CI:1.07-4.25)greater likelihood of alcohol use.Young age and higher educational background were associated with an 11%(OR:0.89,95%CI:0.81-0.98)and 31%(OR:0.69,95%CI:0.49-0.98)less likelihood of cigarette smoking,respectively.Conclusion:Socio-demographic parameters were associated with substance use during pregnancy and warrants targeted health education provided by nurses to pregnant women.
基金supported by the National Key R&D Program of China(No.2019YFB2103003)the Key Research and Development Project of Shaanxi Province(No.2020ZDLNY0608)+3 种基金the Scientific Research Program of Shaanxi Provincial Education Department(No.20JT039)China Postdoctoral Science Foundation(2020M673357)the Youth Innovation Team of Shaanxi Universities in 2020 year(PI:Dr Haihan Zhang)Shaanxi Provincial Program for Innovative Research Team(No.2019TD-025)。
文摘Microbial enzymes are crucial for material biotransformation during the composting process.In this study,we investigated the effects of adding bamboo charcoal(BC)(i.e.,at 5%,10%,and 20%corresponding to BC5,BC10,and BC20,respectively)on the enzyme activity levels during chicken manure composting.The results showed that BC10 could increase the cellulose and urease activities by 56%and 96%,respectively.The bacterial community structure in BC10 differed from those in the other treatments,and Luteivirga,Lactobacillus,Paenalcaligenes,Ulvibacter,Bacillus,Facklamia,Pelagibacterium,Sporosarcina,Cellvibrio,and Corynebacterium had the most important roles in composting.Compared with other treatments,BC10 significantly enhanced the average rates of degradation of carbohydrates(Dxylose(40%)andα-D-lactose(44%))and amino acids(L-arginine(16%),L-asparagine(14%),and L-threonine(52%)).We also explored the associations among the bacterial community and their metabolic functions with the changes in the activities of enzymes.Network analysis demonstrated that BC10 altered the co-occurrence patterns of the bacterial communities,where Ulvibacter and class Bacilli were the keystone bacterial taxa with high capacities for degrading carbon source,and they were related to increases in the activities of cellulase and urease,respectively.The results obtained in this study may help to further enhance the efficiency of composting.
基金This work was funded by Shanghai Pujiang Program(No.18PJ140-6700).
文摘The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer.The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells.The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pathways whose activation sustains cancer growth.Unsurprisingly,it is also one of the most commonly attempted targets for cancer therapy.FK506 binding protein 8(FKBP8)is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptotic function.We aimed to explain these contradictory aspects of FKBP8 in cancer by identifying a“switch”type regulator.We identified through immunoprecipitation--mass spectrometry-based proteomic analysis that the mitochondrial protein prohibitin 1(PHB1)specifically interacts with FKBP8.Furthermore,the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway,whereas the FKBP8 level in the mitochondria was substantially reduced.Moreover,concomitant with these changes,the interaction between FKBP8 and mTOR substantially increased in the absence of PHB1.Collectively,our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular localization and mTOR regulating role.
