Objective:Published studies have found prepulse inhibition(PPI)in schizophrenia is impaired,suggesting PPI may be a biomarker of schizophrenia.We aim to examine whether PPI deficits exist in antipsychotic-na-ve,first-...Objective:Published studies have found prepulse inhibition(PPI)in schizophrenia is impaired,suggesting PPI may be a biomarker of schizophrenia.We aim to examine whether PPI deficits exist in antipsychotic-na-ve,first-episode schizophrenia,and evaluate the effect size of PPI deficits between patients and healthy controls.Methods:The effect size of PPI deficits was evaluated for PPI%by calculating standard mean differences(SMDs)between patients with antipsychotic-na-ve,first-episode schizophrenia and healthy controls.Results:Twelve studies met the inclusion criteria,consisting390antipsychotic-na-ve,first-episode schizophrenia and406healthy controls.The effect sizes of76dB PPI in60ms and120ms interstimulus interval(ISI)were-0.19and-0.41respectively,and the76dB PPI overall effect size was-0.30.The effect sizes of85/86dB PPI in30ms,60ms and120ms ISI were-0.25,-0.42and-0.59respectively,and the85/86dB PPI overall effect size was-0.46.One study were excluded due to heterogeneity in the85/86dB,120ms ISI group,the pooled effect size of the PPI differences between patient group and health control dropped to-0.42,and the overall effect size changed to-0.39.There were no statistical differences in startle magnitude(overall effect size=-0.18)and habituation%(overall effect size=-0.17)between patients and healthy controls.Conclusions:Antipsychotic-na-ve,first-episode schizophrenia patients exhibit robust and reliable deficits in PPI,85/86dB PPI deficit was more severe than76dB PPI,and85/86dB,60-ms ISI PPI was more likely to be a biomarker for schizophrenia,it suggested that the parameters of PPI are particularly significant to affect the effect size so that should be interpreted with cautions in the future studies.展开更多
基金supported by grants from the National Natural Science foundation of China(81471365,81601169)Neuroscience research program of the Beijing science and technology plan(Z161100002616017)+2 种基金Beijing Hospital Authority "young researchers plan"(QML20161901)Foundation and clinical projects of Capital Medical University(16JL25)Excellent personnel project of the Beijing Municipal Committee Organization Department(2015000021469G193)
文摘背景:国外对精神分裂症患者失匹配负波(mismatch negativity,MMN)波幅进行Meta分析发现其明显低于健康对照组,区分效应值(Cohen’s d,)d在1.00左右,使之可能成为精神分裂症早期诊断的生物标志物。但检索文献未发现纳入中国精神分裂症人群MMN研究的Meta分析报道,因此有必要对中国精神分裂症患者的MMN进行Meta分析。目的:通过Meta分析计算中国精神分裂症患者MMN的平均效应值,探讨其是否可作为中国精神分裂症患者的生物标志物。方法:计算机检索中国知网(China National Knowledge Infrastructure,CKNI)、万方数据库(WanF ang Data)、维普数据库(Vip Citation Databases,VIP)、PubM ed数据库,收集2017年5月8日前公开发表的关于中国汉族精神分裂症患者MMN研究的相关文献。MMN受损的影响通过计算精神分裂症患者组和健康对照组之间的标准平均差(SMDs)来评估MMN波幅。结果:共有11篇文献纳入分析。Newcastle-Ottawa Scale(NOS)评估所有研究的总体质量超过6。这些研究的meta分析数据包括精神分裂症患者432例,健康对照人群392例。Meta分析结果显示,精神分裂症组与健康对照组相比MMN受损显著(Cohen’s d=1.004)。剔除异质性大的文献2个,患者组和健康对照组之间MMN差异的效应值降为0.79(Cohen’s d=0.79)。亚组分析显示精神分裂症病程大于3年的患者MMN波幅缺失的效应值为0.95,而病程小于3年的效应值为0.77。通过Egger回归分析得出的发表偏移(t=1.83;p=0.101)提示没有发表偏移。结论:中国精神分裂症患者和健康对照者之间的MMN波幅效应值与其他关于该研究的meta分析结果是一致的,提示中国汉族精神分裂症患者也表现有MMN受损。
基金supported by researchgrants from the National Natural Science foundationof China (81471365, 81601169) Major Brain Program of Beijing Science and Technology Plan (Z161100002616017)Beijing Municipal Administration of Hospitals ClinicalMedicine Development of Special Funding Support(ZYLX201807).
文摘Objective:Published studies have found prepulse inhibition(PPI)in schizophrenia is impaired,suggesting PPI may be a biomarker of schizophrenia.We aim to examine whether PPI deficits exist in antipsychotic-na-ve,first-episode schizophrenia,and evaluate the effect size of PPI deficits between patients and healthy controls.Methods:The effect size of PPI deficits was evaluated for PPI%by calculating standard mean differences(SMDs)between patients with antipsychotic-na-ve,first-episode schizophrenia and healthy controls.Results:Twelve studies met the inclusion criteria,consisting390antipsychotic-na-ve,first-episode schizophrenia and406healthy controls.The effect sizes of76dB PPI in60ms and120ms interstimulus interval(ISI)were-0.19and-0.41respectively,and the76dB PPI overall effect size was-0.30.The effect sizes of85/86dB PPI in30ms,60ms and120ms ISI were-0.25,-0.42and-0.59respectively,and the85/86dB PPI overall effect size was-0.46.One study were excluded due to heterogeneity in the85/86dB,120ms ISI group,the pooled effect size of the PPI differences between patient group and health control dropped to-0.42,and the overall effect size changed to-0.39.There were no statistical differences in startle magnitude(overall effect size=-0.18)and habituation%(overall effect size=-0.17)between patients and healthy controls.Conclusions:Antipsychotic-na-ve,first-episode schizophrenia patients exhibit robust and reliable deficits in PPI,85/86dB PPI deficit was more severe than76dB PPI,and85/86dB,60-ms ISI PPI was more likely to be a biomarker for schizophrenia,it suggested that the parameters of PPI are particularly significant to affect the effect size so that should be interpreted with cautions in the future studies.
