The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural network.The results obtained are matched with the content of personality ...The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural network.The results obtained are matched with the content of personality questionnaires.The Big Five personality traits provide easy differentiation for dividing personalities into different groups.Until now,the highest accuracy obtained from the results of personality prediction from the analysis of brain structure is about 70%.Although there is still no effective evidence to prove a clear relationship between brain structure and personality,the obtained results could prove helpful in understanding the basic relationship between brain structure and personality characteristics.展开更多
In order to distinguish and extract the topic information from other interferential information on the BBC news website for the study in social computing,the BBC News Hunter was proposed in this paper.The whole system...In order to distinguish and extract the topic information from other interferential information on the BBC news website for the study in social computing,the BBC News Hunter was proposed in this paper.The whole system consists of 6 subsystems,respectively named:UI,Control,Download,Analysis,Storage and Log.Numerical experiments show that satisfactory results can be obtained from the BBC news website,whose average accuracy as well as efficiency are acceptable.展开更多
To editor:Cervical insufficiency,or cervical incompetence,is characterized by painless cervix dilatation during the second trimester without contractions.1 It is found in 0.1%–1%of all pregnancies and in up to 8.0%of...To editor:Cervical insufficiency,or cervical incompetence,is characterized by painless cervix dilatation during the second trimester without contractions.1 It is found in 0.1%–1%of all pregnancies and in up to 8.0%of women with recurrent second-trimester miscarriages.2–4 Cervical insufficiency is associated with premature birth,which is a leading cause of neonatal and perinatal mortality and morbidity.展开更多
It has been observed that both cancer tissue cells and normal proliferating cells(NPCs)have the Warburg effect.Our goal here is to demonstrate that they do this for different reasons.To accomplish this,we have analyze...It has been observed that both cancer tissue cells and normal proliferating cells(NPCs)have the Warburg effect.Our goal here is to demonstrate that they do this for different reasons.To accomplish this,we have analyzed the transcriptomic data of over 7000 cancer and control tissues of 14 cancer types in TCGA and data of five NPC types in GEO.Our analyses reveal that NPCs accumulate large quantities of ATPs produced by the respiration process before starting the Warburg effect,to raise the intracellular pH from 6.8 to 7.2 and to prepare for cell division energetically.Once cell cycle starts,the cells start to rely on glycolysis for ATP generation followed by ATP hydrolysis and lactic acid release,to maintain the elevated intracellular pH as needed by cell division since together the three processes are pH neutral.The cells go back to the normal respirationbased ATP production once the cell division phase ends.In comparison,cancer cells have reached their intracellular pH at 7.4 from top down as multiple acid-loading transporters are up-regulated and most acid-extruding ones except for lactic acid exporters are repressed.Cancer cells use continuous glycolysis for ATP production as way to acidify the intracellular space since the lactic acid secretion is decoupled from glycolysis-based ATP generation and is pH balanced by increased expressions of acid-loading transporters.Co-expression analyses suggest that lactic acid secretion is regulated by external,non-pH related signals.Overall,our data strongly suggest that the two cell types have the Warburg effect for very different reasons.展开更多
基金This work was supported in part by the National Natural Science Foundation of China(61972174)the Science and Technology Planning Project of Guangdong Province(2020A0505100018)+1 种基金Guangdong Key-Project for Applied Fundamental Research(2018KZDXM076)Grants-in-Aid for Scientific Research(JP17K00312,JP17H03326)of Japan Society for the Promotion of Science(JSPS).
文摘The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural network.The results obtained are matched with the content of personality questionnaires.The Big Five personality traits provide easy differentiation for dividing personalities into different groups.Until now,the highest accuracy obtained from the results of personality prediction from the analysis of brain structure is about 70%.Although there is still no effective evidence to prove a clear relationship between brain structure and personality,the obtained results could prove helpful in understanding the basic relationship between brain structure and personality characteristics.
文摘In order to distinguish and extract the topic information from other interferential information on the BBC news website for the study in social computing,the BBC News Hunter was proposed in this paper.The whole system consists of 6 subsystems,respectively named:UI,Control,Download,Analysis,Storage and Log.Numerical experiments show that satisfactory results can be obtained from the BBC news website,whose average accuracy as well as efficiency are acceptable.
基金This work was supported by the National Key Research and Development Program of China(no.2021YFC2700700).
文摘To editor:Cervical insufficiency,or cervical incompetence,is characterized by painless cervix dilatation during the second trimester without contractions.1 It is found in 0.1%–1%of all pregnancies and in up to 8.0%of women with recurrent second-trimester miscarriages.2–4 Cervical insufficiency is associated with premature birth,which is a leading cause of neonatal and perinatal mortality and morbidity.
基金funding support from Georgia Research Alliance,the National Natural Science Foundation of China(Grant Nos.61472158,61572228,and 61572227)the Premier-Discipline Enhancement Scheme supported by Zhuhai Government and Premier Key-Discipline Enhancement Scheme supported by Guangdong Government,China
文摘It has been observed that both cancer tissue cells and normal proliferating cells(NPCs)have the Warburg effect.Our goal here is to demonstrate that they do this for different reasons.To accomplish this,we have analyzed the transcriptomic data of over 7000 cancer and control tissues of 14 cancer types in TCGA and data of five NPC types in GEO.Our analyses reveal that NPCs accumulate large quantities of ATPs produced by the respiration process before starting the Warburg effect,to raise the intracellular pH from 6.8 to 7.2 and to prepare for cell division energetically.Once cell cycle starts,the cells start to rely on glycolysis for ATP generation followed by ATP hydrolysis and lactic acid release,to maintain the elevated intracellular pH as needed by cell division since together the three processes are pH neutral.The cells go back to the normal respirationbased ATP production once the cell division phase ends.In comparison,cancer cells have reached their intracellular pH at 7.4 from top down as multiple acid-loading transporters are up-regulated and most acid-extruding ones except for lactic acid exporters are repressed.Cancer cells use continuous glycolysis for ATP production as way to acidify the intracellular space since the lactic acid secretion is decoupled from glycolysis-based ATP generation and is pH balanced by increased expressions of acid-loading transporters.Co-expression analyses suggest that lactic acid secretion is regulated by external,non-pH related signals.Overall,our data strongly suggest that the two cell types have the Warburg effect for very different reasons.
