Dear Editor,Esophageal squamous cell carcinoma(ESCC)is one of the most aggressive squamous cell carcinomas and highly prevalent in Asia.The incidence of ESCC is affected by environmental factors(alcohol consumption,to...Dear Editor,Esophageal squamous cell carcinoma(ESCC)is one of the most aggressive squamous cell carcinomas and highly prevalent in Asia.The incidence of ESCC is affected by environmental factors(alcohol consumption,tobacco use,etc.)and genetic factors,both result in tumorigenesis by altering proteomic,posttranslational modification(PTM)and metabolic characterization of esophageal epithelial cells.Recently,large-scale investigations of ESCC have been performed,focusing on the discovery of new driver mutations.However,the mechanisms underlying ESCC development remain unclear,and comprehensive protein profiling of ESCC is necessary to understand its underlying mechanisms.So far,the approaches to the treatment of ESCC patients mainly include endoscopic therapy,surgery and chemoradiotherapy.However,most patients especially with poor prognosis ESCC still lack effective targeted treatment.展开更多
基金This project was funded by the National Natural Science Foundation of China(81972634,81773134)the National Key R&D Program of China(2020YFA0803300)+3 种基金CAMS Initiative for Innovative Medicine(2017-I2M-1-005,2019-I2M-1-003,2016-I2M1-001)the fund of“San-ming”Project of Medicine in Shenzhen(SZSM201812062)National Natural Science Foundation of China(81802440)China Postdoctoral Science Foundation(2019M651071)。
文摘Dear Editor,Esophageal squamous cell carcinoma(ESCC)is one of the most aggressive squamous cell carcinomas and highly prevalent in Asia.The incidence of ESCC is affected by environmental factors(alcohol consumption,tobacco use,etc.)and genetic factors,both result in tumorigenesis by altering proteomic,posttranslational modification(PTM)and metabolic characterization of esophageal epithelial cells.Recently,large-scale investigations of ESCC have been performed,focusing on the discovery of new driver mutations.However,the mechanisms underlying ESCC development remain unclear,and comprehensive protein profiling of ESCC is necessary to understand its underlying mechanisms.So far,the approaches to the treatment of ESCC patients mainly include endoscopic therapy,surgery and chemoradiotherapy.However,most patients especially with poor prognosis ESCC still lack effective targeted treatment.
