Currently,osteochondral(OC)tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage.However,it is still c...Currently,osteochondral(OC)tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage.However,it is still challenging to ensure the integrity,physiological function and regeneration ability of stratified OC scaffolds in clinical application.Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue.As a consequence,the researches on biomimetic design to achieve the tissue function of each layer,and additive manufacture(AM)to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress.In this review,the design methods of biomaterial and structure as well as computer-aided design,and performance prediction of biopolymer-based OC scaffolds are presented;then,the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized;finally,the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.展开更多
IntroductionBone defect caused by specific diseases or medications is very common. Autologous bone, allogeneic bone or xenogeneic bone transplantation is commonly used in clinical practice. However, autologous bone so...IntroductionBone defect caused by specific diseases or medications is very common. Autologous bone, allogeneic bone or xenogeneic bone transplantation is commonly used in clinical practice. However, autologous bone sources are limited. Xenogeneic bone cannot participate in metabolism. Because of the development of bone tissue engineering, the transplantation of new scaffold materials and autologous cells has opened up new treatment options for bone defects. The bone tissue engineering principle is applied to construct a degradable porous bone scaffold, which is implanted into the human body after loading bone cells, growth factors, etc.展开更多
基金Funding was supported by the Key Research and Development Program of Shaanxi Province(Grant No.2020ZDLSF04-07)the National Key Research and Development Program of China(Grant No.2019QY(Y)0502)+2 种基金the National Natural Science Foundation of China(Grant No.51905438)the Innovation Platform of Biofabrication(Grant No.17SF0002)the Fundamental Research Funds for the Central Universities(Grant No.31020190502009).
文摘Currently,osteochondral(OC)tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage.However,it is still challenging to ensure the integrity,physiological function and regeneration ability of stratified OC scaffolds in clinical application.Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue.As a consequence,the researches on biomimetic design to achieve the tissue function of each layer,and additive manufacture(AM)to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress.In this review,the design methods of biomaterial and structure as well as computer-aided design,and performance prediction of biopolymer-based OC scaffolds are presented;then,the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized;finally,the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.
文摘IntroductionBone defect caused by specific diseases or medications is very common. Autologous bone, allogeneic bone or xenogeneic bone transplantation is commonly used in clinical practice. However, autologous bone sources are limited. Xenogeneic bone cannot participate in metabolism. Because of the development of bone tissue engineering, the transplantation of new scaffold materials and autologous cells has opened up new treatment options for bone defects. The bone tissue engineering principle is applied to construct a degradable porous bone scaffold, which is implanted into the human body after loading bone cells, growth factors, etc.
