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利用秀丽线虫评价神经传递抑制肽的祛皱功效研究 被引量:1
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作者 刘涵 郭朝万 +3 位作者 陈杰 聂艳峰 胡露 王娟 《日用化学工业(中英文)》 CAS 北大核心 2022年第11期1188-1194,共7页
随着化妆品行业迈进高科技发展时期,人们更加注重皮肤的保养,特别是对皮肤纹理平整和皱纹淡化的需求剧增,然而抗皱类化妆品或原料的功效评估存在周期较长、费用较高且无法实现高通量检测的问题。因此,建立可行、有效的替代检测模型实现... 随着化妆品行业迈进高科技发展时期,人们更加注重皮肤的保养,特别是对皮肤纹理平整和皱纹淡化的需求剧增,然而抗皱类化妆品或原料的功效评估存在周期较长、费用较高且无法实现高通量检测的问题。因此,建立可行、有效的替代检测模型实现化妆品原料祛皱功效的快速评价对化妆品开发具有重要意义。作者以秀丽线虫为模式生物,研究几种神经传递抑制类化妆品祛皱多肽对其运动行为和神经递质传导相关酶活性的影响,从而实现化妆品原料祛皱功效的定性定量检测。结果表明,红蝎素、蛇毒肽、芋螺肽以及红蝎素EX(红蝎素和芋螺肽的复配肽)均有一定的阻断神经与肌肉间神经冲动、抵御兴奋刺激条件下线虫神经与肌肉间神经冲动以及显著抑制线虫的运动行为的能力。此外,神经递质传导相关酶活性的数据表明上述神经抑制类多肽是通过刺激钙调神经磷酸酶CaN过表达同时抑制乙酰胆碱酯酶AchE的活力,从而阻断神经与肌肉间神经递质的传递,抑制神经冲动,使肌肉达到放松进而平整皮肤表面、达到祛皱的效果。 展开更多
关键词 秀丽线虫 运动行为 神经传递抑制 祛皱
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Sensitive skin syndrome: Research progress on mechanisms and applications
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作者 Chuanxia Jiang Chaowan Guo +7 位作者 Jipeng Yan Jie Chen Shujing Peng Haishu Huang Weizhi Wu yanfeng nie Yunlin Pei Huaiqing Sun 《Journal of dermatologic science and cosmetic technology》 2024年第2期63-70,共8页
Sensitive skin is a clinical syndrome characterized by a hyper-reactive state of the skin,primarily on the face.It is accompanied by subjective symptoms such as burning,stinging,itching,and tightness when exposed to p... Sensitive skin is a clinical syndrome characterized by a hyper-reactive state of the skin,primarily on the face.It is accompanied by subjective symptoms such as burning,stinging,itching,and tightness when exposed to physical,chemical,or psychological stimuli.Objective signs,such as erythema,scales,and dilated blood vessels,may or may not be present.The discomfort associated with sensitive skin can be triggered by various endogenous and exogenous factors,which usually have no significant effect on the individual and do not induce irritant reactions.Sensitive skin often presents as a subjective state without clinical signs and exhibits diversity,posing challenges in sensitive skin research and care.This review summarizes the prevalence,key factors,pathophysiological mechanisms,diagnosis,and progress in daily care for sensitive skin.The aim is to provide a clearer and more systematic understanding of sensitive skin and offer guidance for sensitive skin care. 展开更多
关键词 Sensitive skin Endogenous and exogenous factors Epidemiology Pathophysiological mechanisms Sensitive skin care
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