OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines(TCM) with the property of activating blood and resolving stasis in terms of TCM theory.METHODS: The 31 TCM...OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines(TCM) with the property of activating blood and resolving stasis in terms of TCM theory.METHODS: The 31 TCMs extracts were prepared using water, 90% ethanol and ethyl acetate., and the effects on anti-platelet aggregation were tested on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate, bovine thrombin and arachi-donic acid(AA) as aggregation inducers, respectively. Aspirin was the positive control.RESULTS: Lots of the tested TCMs had inhibitory effects with concentration-dependent manner on platelet aggregations induced by various agonists.Especially, some of the TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae) showed good anti-platelet aggregation effect similar or higher than that in positive control group.CONCLUSION: The study provided scientific references that several TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae),possess the property of anti-platelet aggregation.展开更多
The Late Permian to Early Triassic transition represents one of the most important Phanerozoic mass extinction episodes. The cause of this event is still in debate between catastrophic and gradual mechanisms. This stu...The Late Permian to Early Triassic transition represents one of the most important Phanerozoic mass extinction episodes. The cause of this event is still in debate between catastrophic and gradual mechanisms. This study uses the U-Pb method on zircons from the uppermost Permian/lowermost Triassic clay deposits at Chahe (Guizhou Province, SW China) to examine time constraints for this event. The results of both this and previous studies show that the ages of Bed 68a and 68c (the upper clay bed of the terrestrial Permian-Triassic boundary (PTB)) respectively are 252.6±2.8 and 247.5±2.8 Ma. This age (within the margin of error) almost accords with the upper clay bed (Bed 28) age of Meishan and the eruption age of Tunguss Basalt, and is so far the most accurate age obtained from terrestrial PTB. The claystone of Bed 68 was formed in the earliest Triassic. The biotic crisis occurred at nearly the same time in terrestrial and marine environments during Permian-Triassic interval; however the extinction patterns and processes are different. The extinction pattern of the terrestrial plants shows a major decline at the PTB after long-term evolution, followed by a retarded extinction of the relicts in the earliest Triassic.展开更多
基金the National Natural Science Foundation of China(Magnetic Nanoparticles-based Cell Affinity Capillary Electrochromatography and Its Applications,No.21275169Screening of Bioactive Compounds From Typical Huoxue Huayu Medicine by Platelet Based Capillary Electrochromatography,No.81202886)+1 种基金the Fundamental Research Funds for the Central Universities(Study on the Quality Control Method for the Animal Glue Medicine,No.CQDXWL-2012-028)the Chongqing Postdoctoral Funds(No.RC20120027)
文摘OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines(TCM) with the property of activating blood and resolving stasis in terms of TCM theory.METHODS: The 31 TCMs extracts were prepared using water, 90% ethanol and ethyl acetate., and the effects on anti-platelet aggregation were tested on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate, bovine thrombin and arachi-donic acid(AA) as aggregation inducers, respectively. Aspirin was the positive control.RESULTS: Lots of the tested TCMs had inhibitory effects with concentration-dependent manner on platelet aggregations induced by various agonists.Especially, some of the TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae) showed good anti-platelet aggregation effect similar or higher than that in positive control group.CONCLUSION: The study provided scientific references that several TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae),possess the property of anti-platelet aggregation.
基金the National Natural Science Foundation of China (Grant No. 40232025)
文摘The Late Permian to Early Triassic transition represents one of the most important Phanerozoic mass extinction episodes. The cause of this event is still in debate between catastrophic and gradual mechanisms. This study uses the U-Pb method on zircons from the uppermost Permian/lowermost Triassic clay deposits at Chahe (Guizhou Province, SW China) to examine time constraints for this event. The results of both this and previous studies show that the ages of Bed 68a and 68c (the upper clay bed of the terrestrial Permian-Triassic boundary (PTB)) respectively are 252.6±2.8 and 247.5±2.8 Ma. This age (within the margin of error) almost accords with the upper clay bed (Bed 28) age of Meishan and the eruption age of Tunguss Basalt, and is so far the most accurate age obtained from terrestrial PTB. The claystone of Bed 68 was formed in the earliest Triassic. The biotic crisis occurred at nearly the same time in terrestrial and marine environments during Permian-Triassic interval; however the extinction patterns and processes are different. The extinction pattern of the terrestrial plants shows a major decline at the PTB after long-term evolution, followed by a retarded extinction of the relicts in the earliest Triassic.
