The rescue of dying cardiomyocytes in penumbra within 4 hours is the best way to preserve cardiac function in acute myocardial infarction(AMI).Mitochondrial fission contributes to mitochondrial energy supply deficienc...The rescue of dying cardiomyocytes in penumbra within 4 hours is the best way to preserve cardiac function in acute myocardial infarction(AMI).Mitochondrial fission contributes to mitochondrial energy supply deficiency and cardiomyocytes death,and OMA1 promotes mitochondrial fission.Accurate targeting of OMA1 inhibition is important for the treatment of myocardial infarction.Here,a selective inhibitor of OMA1,UNC-R,was firstly described,which could protect the cardiomyocytes through mitochondrial fission inhibition.Moreover,the accurately targeted microsphere was designed,and loaded the UNC-R to form the POMU,which could avoid the phagocytosis of phagocytes in blood,precisely accumulated in the ischemic area,further target the dying cardiomyocytes.展开更多
文摘The rescue of dying cardiomyocytes in penumbra within 4 hours is the best way to preserve cardiac function in acute myocardial infarction(AMI).Mitochondrial fission contributes to mitochondrial energy supply deficiency and cardiomyocytes death,and OMA1 promotes mitochondrial fission.Accurate targeting of OMA1 inhibition is important for the treatment of myocardial infarction.Here,a selective inhibitor of OMA1,UNC-R,was firstly described,which could protect the cardiomyocytes through mitochondrial fission inhibition.Moreover,the accurately targeted microsphere was designed,and loaded the UNC-R to form the POMU,which could avoid the phagocytosis of phagocytes in blood,precisely accumulated in the ischemic area,further target the dying cardiomyocytes.
