A Study on Adsorption of Electrogenerated Cystine Precipitate onto An Electrode using Electrochemical Quartz Crystal Impedance System

An electrochemical quartz crystal impedance system has been applied to monitorgeneration of precipitate and adsorption of the precipitate onto An electrode during electrochmicaloxidation and Fe(CN)_6,3-/Fe(CN),6 4- electrochemical catalytic oxidation of L-cysteine in phosphateaqueous buffer (pH 7.4). Significant decreases in the resonant frequency and increases in themotional resistance and the static capacitance were found during the precipitate adsorption, and thefrequency shift found in solution was ca. 2 times that in air. Similar responses of quartz crystalimpedance and a white precipitate were obtained during redox titration of L-cysteine solutionusing K_3Fe(CN)_6 solution. FT-IR analysis indicated that the white precipitate is cystine. Theelectrode collection efficiency of the electrogenerated cystine was estimated.

Practical synthesis of methyl(E)-2-(3-(3-(2-(7-chloro-2- quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate,a key intermediate of Montelukast

一篇小说和实际合成线路为甲基的准备被介绍 --(E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate, Montelukast 的关键中介，一个 leukotriene 对手。主要 diarylpropane 框架经由导致亲核的替换反应跟随的酰阴离子等价物的极性谈话反应被准备。这条途径的全面收益是 61% 。这个方法为操作简单并且对工业生产合适。

A novel and efficient route for the preparation of atorvastatin

atorvastatin 的一个新奇、有效的合成方法被描述。合成的关键步经由 HornerWadsworthEmmons 反应是在 chiral 方面链和骨骼之间的石蜡连接的构造，导致在在 Pd/C 上的石蜡的加氢下面的 atorvastatin 的先进中介。这个新奇方法比它的文件报导方法的为 atorvastatin 的实际合成是更有用的。