目的:探讨新型温控射频对产后阴道松弛症的临床疗效与安全性。方法:选取2022年6月-2023年6月于清华大学附属北京清华长庚医院收治的43例产后阴道松弛症患者为研究对象,随机分为2组,试验组(21例)接受新型温控射频治疗,对照组(22例)接受...目的:探讨新型温控射频对产后阴道松弛症的临床疗效与安全性。方法:选取2022年6月-2023年6月于清华大学附属北京清华长庚医院收治的43例产后阴道松弛症患者为研究对象,随机分为2组,试验组(21例)接受新型温控射频治疗,对照组(22例)接受假开机治疗(无温度及能量)。通过比较治疗前后女性性功能指数量表(female sexual function index,FSFI)、女性性困扰诊断量表修订版(female sexual distress scale-revised,FSDS-R)、阴道松弛问卷(vaginal laxity questionnaire,VLQ)以及性生活满意度问卷(sexual satisfaction questionnaire,SSQ)的主观评分,结合对小阴唇基底边长、外阴着色和弹性等指标的客观评估,综合评价射频治疗的临床疗效与安全性。结果:试验组患者首次治疗后第18周较基线的FSFI总分改变值(△T)的均值为(8.72±3.94)分,对照组(△C)为(-0.03±1.28)分,2组平均FSFI总分改变值的差值(△T-△C)为8.75分,95%CI为6.889~10.613分,组间差值的95%CI下限大于0,试验组FSFI评分优于对照组(t=4.810,P<0.001)。两因素重复测量方差分析结果显示,FSFI评分的时间主效应(F时间=24.156,P时间<0.001)、组别主效应(F组别=12.754,P组别=0.001)、时间×组别的交互作用(F时间×组别=25.689,P时间×组别<0.001)均有统计学意义。以组别为自变量的干预效应表明,治疗6、10、18周后,试验组FSFI评分高于对照组,差异有统计学意义(均P<0.05)。以时间为自变量的时间效应表明,治疗后各时间点的FSFI评分均高于治疗前,且治疗6、10、18周后的FSFI评分均高于治疗3周后,差异有统计学意义(均P<0.05);而治疗6、10、18周后的FSFI评分比较,差异无统计学意义(均P>0.05)。治疗10、18周后,试验组FSDS-R评分、小阴唇基底边长均低于对照组,SSQ评分高于对照组,差异有统计学意义(均P<0.05)。治疗3、6、10、18周后,试验组VLQ评分、指测阴道松弛改善程度及外阴状态均优于对照组,差异均有统计学意义(均P<0.05)。所有入组患者均未出现与试验器械相关的不良事件。结论:新型温控射频技术有助于改善患者阴道松弛度,提高性生活满意度,治疗安全性高,值得临床推广应用。展开更多
To ensure the safe performance of deep-sea mining vehicles(DSMVs),it is necessary to study the mechanical characteristics of the interaction between the seabed soil and the track plate.The rotation and digging motions...To ensure the safe performance of deep-sea mining vehicles(DSMVs),it is necessary to study the mechanical characteristics of the interaction between the seabed soil and the track plate.The rotation and digging motions of the track plate are important links in the contact between the driving mechanism of the DSMV and seabed soil.In this study,a numerical simulation is conducted using the coupled Eulerian–Lagrangian(CEL)large deformation numerical method to investigate the interaction between the track plate of the DSMV and the seabed soil under two working conditions:rotating condition and digging condition.First,a soil numerical model is established based on the elastoplastic mechanical characterization using the basic physical and mechanical properties of the seabed soil obtained by in situ sampling.Subsequently,the soil disturbance mechanism and the dynamic mechanical response of the track plate under rotating and digging conditions are obtained through the analysis of the sensitivity of the motion parameters,the grouser structure,the layered soil features and the soil heterogeneity.The results indicate that the above parameters remarkably influence the interaction between the DSMV and the seabed soil.Therefore,it is important to consider the rotating and digging motion of the DSMV in practical engineering to develop a detailed optimization design of the track plate.展开更多
文摘目的:探讨新型温控射频对产后阴道松弛症的临床疗效与安全性。方法:选取2022年6月-2023年6月于清华大学附属北京清华长庚医院收治的43例产后阴道松弛症患者为研究对象,随机分为2组,试验组(21例)接受新型温控射频治疗,对照组(22例)接受假开机治疗(无温度及能量)。通过比较治疗前后女性性功能指数量表(female sexual function index,FSFI)、女性性困扰诊断量表修订版(female sexual distress scale-revised,FSDS-R)、阴道松弛问卷(vaginal laxity questionnaire,VLQ)以及性生活满意度问卷(sexual satisfaction questionnaire,SSQ)的主观评分,结合对小阴唇基底边长、外阴着色和弹性等指标的客观评估,综合评价射频治疗的临床疗效与安全性。结果:试验组患者首次治疗后第18周较基线的FSFI总分改变值(△T)的均值为(8.72±3.94)分,对照组(△C)为(-0.03±1.28)分,2组平均FSFI总分改变值的差值(△T-△C)为8.75分,95%CI为6.889~10.613分,组间差值的95%CI下限大于0,试验组FSFI评分优于对照组(t=4.810,P<0.001)。两因素重复测量方差分析结果显示,FSFI评分的时间主效应(F时间=24.156,P时间<0.001)、组别主效应(F组别=12.754,P组别=0.001)、时间×组别的交互作用(F时间×组别=25.689,P时间×组别<0.001)均有统计学意义。以组别为自变量的干预效应表明,治疗6、10、18周后,试验组FSFI评分高于对照组,差异有统计学意义(均P<0.05)。以时间为自变量的时间效应表明,治疗后各时间点的FSFI评分均高于治疗前,且治疗6、10、18周后的FSFI评分均高于治疗3周后,差异有统计学意义(均P<0.05);而治疗6、10、18周后的FSFI评分比较,差异无统计学意义(均P>0.05)。治疗10、18周后,试验组FSDS-R评分、小阴唇基底边长均低于对照组,SSQ评分高于对照组,差异有统计学意义(均P<0.05)。治疗3、6、10、18周后,试验组VLQ评分、指测阴道松弛改善程度及外阴状态均优于对照组,差异均有统计学意义(均P<0.05)。所有入组患者均未出现与试验器械相关的不良事件。结论:新型温控射频技术有助于改善患者阴道松弛度,提高性生活满意度,治疗安全性高,值得临床推广应用。
基金supported by the Natural Science Foundation of Hainan Province(Grant No.520LH015)the Fundamental Research Funds for the Central Universities and the Major Projects of Strategic Emerging Industries in Shanghai(Grant No.BH3230001).
文摘To ensure the safe performance of deep-sea mining vehicles(DSMVs),it is necessary to study the mechanical characteristics of the interaction between the seabed soil and the track plate.The rotation and digging motions of the track plate are important links in the contact between the driving mechanism of the DSMV and seabed soil.In this study,a numerical simulation is conducted using the coupled Eulerian–Lagrangian(CEL)large deformation numerical method to investigate the interaction between the track plate of the DSMV and the seabed soil under two working conditions:rotating condition and digging condition.First,a soil numerical model is established based on the elastoplastic mechanical characterization using the basic physical and mechanical properties of the seabed soil obtained by in situ sampling.Subsequently,the soil disturbance mechanism and the dynamic mechanical response of the track plate under rotating and digging conditions are obtained through the analysis of the sensitivity of the motion parameters,the grouser structure,the layered soil features and the soil heterogeneity.The results indicate that the above parameters remarkably influence the interaction between the DSMV and the seabed soil.Therefore,it is important to consider the rotating and digging motion of the DSMV in practical engineering to develop a detailed optimization design of the track plate.
基金Supported by the National Natural Science Foundation of China(Project No.51779141)the 7th Generation Ultra Deep Water Drilling Unit Innovation Project~~
