To better understand the community structure characteristics of zooplankton in the artificial reef area of Tianjin in the Bohai Bay and its relationship with major environmental factors,the project conducted three cru...To better understand the community structure characteristics of zooplankton in the artificial reef area of Tianjin in the Bohai Bay and its relationship with major environmental factors,the project conducted three cruise surveys in the spring(May),summer(July)and autumn(October)of 2016 and monitored conventional environmental factors.The results showed that there were 36 species of zooplankton,including 14 species of copepods,phytoplankton larvae 12 species;6 kinds of coelenterates;3 species of shrimp and 1 species of hairy shrimp in the artificial reef area of Tianjin in the three cruise surveys.The dominant species in spring,summer,and autumn have obvious changes,among which the dominant species in spring are Eurytemora pacifica,Clytia hemisphoerica,Clalnus sinicus,and Macruran larva;in summer are Oithona similis and Brachyura zoea larva;and autumn only the Clalnus sinicus.Correlation analysis shows that the diversity and uniformity of zooplankton in the artificial reef area have increased to varying degrees,indicating that the overall construction of artificial reefs in the Tianjin sea area has improved the marine ecological protection to some extent.The results of CCA showed that salinity and water temperature were the main environmental factors affecting the distribution of zooplankton communities in artificial reefs in Tianjin.展开更多
In subjects with type 2 diabetes inadequately controlled with oral antidiabetic agents （OADs）, insulin therapy is usually started to improve glycaemic control after failure of diet, exercise and OADs.1 Although ther...In subjects with type 2 diabetes inadequately controlled with oral antidiabetic agents （OADs）, insulin therapy is usually started to improve glycaemic control after failure of diet, exercise and OADs.1 Although there is no standard way to introduce insulin treatment, premixed formulations are a popular option. They offer an alternative to basal-bolus therapy and provide basal and prandial coverage with a single injection. Indeed, Koivisto et al2 in 1999 reported that 39% of patients with type 2 diabetes worldwide used premixed insulin as part of their therapeutic regimen, The modern premixed insulins, such as biphasic insulin aspart 30 （BIAsp 30） are most frequently prescribed twice-daily （BID） in clinical practice. However,展开更多
Background Currently it is unclear whether lipid accumulation occurs in a particular sequence and its relationship with whole body insulin resistance （IR）. This study aimed to answer this question.Methods Male Sprag...Background Currently it is unclear whether lipid accumulation occurs in a particular sequence and its relationship with whole body insulin resistance （IR）. This study aimed to answer this question.Methods Male Sprague-Dawley （SD） rats were fed on a normal or a high-fat diet for 20 weeks. Serum triglycerides （TG）, serum free fatty acids （FFA）, fasting plasma glucose （FPG）, and liver and skeletal muscle TG were measured. The glucose infusion rate （GIR） and mRNA levels of acetyl-CoA carboxylase （ACC） and carnitine palmitoyltransferase-1 （CPT-1） in the liver and skeletal muscle were determined at different stages.Results Compared with rats fed on the normal diet, serum FFA was not significantly increased in rats fed on the high-fat diet until 20 weeks. In contrast, liver TG was significantly increased by the high-fat diet by four weeks （20-fold; P ＜0.01）,and remained elevated until the end of the study. However, skeletal muscle TG was not significantly increased by the high-fat diet until 20 weeks （10.6-fold; P＜0.01）, and neither was the FPG. The GIR was significantly reduced （1.6-fold; P ＜0.01） by the high-fat diet after 8 weeks. The mRNA levels of ACC gradually increased over time and CPT-1 decreased over time, in both the liver and skeletal muscle in rats fed the high-fat diet.Conclusions Lipid accumulation in the liver occurs earlier than lipid accumulation in the skeletal muscle. Fatty liver may be one of the early markers of whole body IR. Changes in the gene expression levels of ACC and CPT-1 may have important roles in the process of IR development.展开更多
Background The association between IGF2BP2 and type 2 diabetes mellitus （T2DM） has been repeatedly confirmed among different ethnic populations. However, in several genome-wide association studies （GWAS） from the ...Background The association between IGF2BP2 and type 2 diabetes mellitus （T2DM） has been repeatedly confirmed among different ethnic populations. However, in several genome-wide association studies （GWAS） from the Chinese Han population, the gene IGF2BP2 has not been replicated. The results of relevant studies for the association between IGF2BP2 and T2DM showed controversy in Chinese Han population. It is necessary to systematically evaluate the contribution of common variants in IGF2BP2 to T2DM in Chinese Han population.展开更多
文摘To better understand the community structure characteristics of zooplankton in the artificial reef area of Tianjin in the Bohai Bay and its relationship with major environmental factors,the project conducted three cruise surveys in the spring(May),summer(July)and autumn(October)of 2016 and monitored conventional environmental factors.The results showed that there were 36 species of zooplankton,including 14 species of copepods,phytoplankton larvae 12 species;6 kinds of coelenterates;3 species of shrimp and 1 species of hairy shrimp in the artificial reef area of Tianjin in the three cruise surveys.The dominant species in spring,summer,and autumn have obvious changes,among which the dominant species in spring are Eurytemora pacifica,Clytia hemisphoerica,Clalnus sinicus,and Macruran larva;in summer are Oithona similis and Brachyura zoea larva;and autumn only the Clalnus sinicus.Correlation analysis shows that the diversity and uniformity of zooplankton in the artificial reef area have increased to varying degrees,indicating that the overall construction of artificial reefs in the Tianjin sea area has improved the marine ecological protection to some extent.The results of CCA showed that salinity and water temperature were the main environmental factors affecting the distribution of zooplankton communities in artificial reefs in Tianjin.
文摘In subjects with type 2 diabetes inadequately controlled with oral antidiabetic agents （OADs）, insulin therapy is usually started to improve glycaemic control after failure of diet, exercise and OADs.1 Although there is no standard way to introduce insulin treatment, premixed formulations are a popular option. They offer an alternative to basal-bolus therapy and provide basal and prandial coverage with a single injection. Indeed, Koivisto et al2 in 1999 reported that 39% of patients with type 2 diabetes worldwide used premixed insulin as part of their therapeutic regimen, The modern premixed insulins, such as biphasic insulin aspart 30 （BIAsp 30） are most frequently prescribed twice-daily （BID） in clinical practice. However,
基金This research was partly supported by a grant from the National Natural Science Foundation of China （No. 30670995）.
文摘Background Currently it is unclear whether lipid accumulation occurs in a particular sequence and its relationship with whole body insulin resistance （IR）. This study aimed to answer this question.Methods Male Sprague-Dawley （SD） rats were fed on a normal or a high-fat diet for 20 weeks. Serum triglycerides （TG）, serum free fatty acids （FFA）, fasting plasma glucose （FPG）, and liver and skeletal muscle TG were measured. The glucose infusion rate （GIR） and mRNA levels of acetyl-CoA carboxylase （ACC） and carnitine palmitoyltransferase-1 （CPT-1） in the liver and skeletal muscle were determined at different stages.Results Compared with rats fed on the normal diet, serum FFA was not significantly increased in rats fed on the high-fat diet until 20 weeks. In contrast, liver TG was significantly increased by the high-fat diet by four weeks （20-fold; P ＜0.01）,and remained elevated until the end of the study. However, skeletal muscle TG was not significantly increased by the high-fat diet until 20 weeks （10.6-fold; P＜0.01）, and neither was the FPG. The GIR was significantly reduced （1.6-fold; P ＜0.01） by the high-fat diet after 8 weeks. The mRNA levels of ACC gradually increased over time and CPT-1 decreased over time, in both the liver and skeletal muscle in rats fed the high-fat diet.Conclusions Lipid accumulation in the liver occurs earlier than lipid accumulation in the skeletal muscle. Fatty liver may be one of the early markers of whole body IR. Changes in the gene expression levels of ACC and CPT-1 may have important roles in the process of IR development.
文摘Background The association between IGF2BP2 and type 2 diabetes mellitus （T2DM） has been repeatedly confirmed among different ethnic populations. However, in several genome-wide association studies （GWAS） from the Chinese Han population, the gene IGF2BP2 has not been replicated. The results of relevant studies for the association between IGF2BP2 and T2DM showed controversy in Chinese Han population. It is necessary to systematically evaluate the contribution of common variants in IGF2BP2 to T2DM in Chinese Han population.
