Tumor immunotherapy represents a pivotal scientific advancement,and the traditional Chinese medicine tenet of harmonizing the body’s equilibrium through the‘Yin-Yang(Yin and Yang refer to the two basic properties of...Tumor immunotherapy represents a pivotal scientific advancement,and the traditional Chinese medicine tenet of harmonizing the body’s equilibrium through the‘Yin-Yang(Yin and Yang refer to the two basic properties of things and things that are opposed to each other)balance’aligns conceptually with tumor immunotherapy’s goal of reinstating the immune system’s functionality[1].Current research suggests that incorporating the‘Yin-Yang balance’philosophy to guide traditional Chinese medicine polysaccharides in immune anti-tumor therapy may amplify their effectiveness in treating tumors[2].However,prevailing studies on the anti-tumor immune response of traditional Chinese medicine polysaccharides primarily focus on enhancing immune function,often overlooking a comprehensive exploration of immunosuppressive factors.Concurrently,the intricacies involved in analyzing and deciphering the composition and structure of traditional Chinese medicine polysaccharides have exacerbated the challenges associated with studying their oral absorption metabolism and in vivo mechanisms of action.This article addresses these intricacies by consolidating research on the structure-activity relationship,absorption and metabolism processes,and the molecular mechanisms influencing tumor immunity related to traditional Chinese medicine polysaccharides.Furthermore,it proposes a strategic framework for advancing the regulation of tumor immune responses through traditional Chinese medicine polysaccharides.This comprehensive exploration aims to establish a robust foundation for the development of novel oral Chinese herbal polysaccharide drugs tailored for the field of tumor immunotherapy.展开更多
Smart nanoparticles,which can respond to biological cues or be guided by them,are emerging as a promising drug delivery platform for precise cancer treatment.The field of oncology,nanotechnology,and biomedicine has wi...Smart nanoparticles,which can respond to biological cues or be guided by them,are emerging as a promising drug delivery platform for precise cancer treatment.The field of oncology,nanotechnology,and biomedicine has witnessed rapid progress,leading to innovative developments in smart nanoparticles for safer and more effective cancer therapy.In this review,we will highlight recent advancements in smart nanoparticles,including polymeric nanoparticles,dendrimers,micelles,liposomes,protein nanoparticles,cell membrane nanoparticles,mesoporous silica nanoparticles,gold nanoparticles,iron oxide nanoparticles,quantum dots,carbon nanotubes,black phosphorus,MOF nanoparticles,and others.We will focus on their classification,structures,synthesis,and intelligent features.These smart nanoparticles possess the ability to respond to various external and internal stimuli,such as enzymes,pH,temperature,optics,and magnetism,making them intelligent systems.Additionally,this review will explore the latest studies on tumor targeting by functionalizing the surfaces of smart nanoparticles with tumor-specific ligands like antibodies,peptides,transferrin,and folic acid.We will also summarize different types of drug delivery options,including small molecules,peptides,proteins,nucleic acids,and even living cells,for their potential use in cancer therapy.While the potential of smart nanoparticles is promising,we will also acknowledge the challenges and clinical prospects associated with their use.Finally,we will propose a blueprint that involves the use of artificial intelligence-powered nanoparticles in cancer treatment applications.By harnessing the potential of smart nanoparticles,this review aims to usher in a new era of precise and personalized cancer therapy,providing patients with individualized treatment options.展开更多
基金supported by the Starting Research Fund from the Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital(No.30420220004)Central Government Guides Local Science and Technology Development Fund Project(No.23ZYZYTS0260)Sichuan Province Science and Technology Activities Funding for Returned Overseas Scholars.
文摘Tumor immunotherapy represents a pivotal scientific advancement,and the traditional Chinese medicine tenet of harmonizing the body’s equilibrium through the‘Yin-Yang(Yin and Yang refer to the two basic properties of things and things that are opposed to each other)balance’aligns conceptually with tumor immunotherapy’s goal of reinstating the immune system’s functionality[1].Current research suggests that incorporating the‘Yin-Yang balance’philosophy to guide traditional Chinese medicine polysaccharides in immune anti-tumor therapy may amplify their effectiveness in treating tumors[2].However,prevailing studies on the anti-tumor immune response of traditional Chinese medicine polysaccharides primarily focus on enhancing immune function,often overlooking a comprehensive exploration of immunosuppressive factors.Concurrently,the intricacies involved in analyzing and deciphering the composition and structure of traditional Chinese medicine polysaccharides have exacerbated the challenges associated with studying their oral absorption metabolism and in vivo mechanisms of action.This article addresses these intricacies by consolidating research on the structure-activity relationship,absorption and metabolism processes,and the molecular mechanisms influencing tumor immunity related to traditional Chinese medicine polysaccharides.Furthermore,it proposes a strategic framework for advancing the regulation of tumor immune responses through traditional Chinese medicine polysaccharides.This comprehensive exploration aims to establish a robust foundation for the development of novel oral Chinese herbal polysaccharide drugs tailored for the field of tumor immunotherapy.
基金supported by the National Natural Science Foundation of China(U2230123,31900984,81972901,82304969,82304789)the National Key Research and Development Program of China(2020YFC2005500)+2 种基金the Central Guide Local Science and Technology Development Fund(2022ZYD0080)the Key Research and Development Program of Science and Technology Department of Sichuan Province(2023YFS0110,2023YFS0125,2023YFS0131,2023NSFSC0033,2022YFS0159,2022YFS0606,2019YFS0514)China Postdoctoral Science Foundation(2022M710623,2022M720670).
文摘Smart nanoparticles,which can respond to biological cues or be guided by them,are emerging as a promising drug delivery platform for precise cancer treatment.The field of oncology,nanotechnology,and biomedicine has witnessed rapid progress,leading to innovative developments in smart nanoparticles for safer and more effective cancer therapy.In this review,we will highlight recent advancements in smart nanoparticles,including polymeric nanoparticles,dendrimers,micelles,liposomes,protein nanoparticles,cell membrane nanoparticles,mesoporous silica nanoparticles,gold nanoparticles,iron oxide nanoparticles,quantum dots,carbon nanotubes,black phosphorus,MOF nanoparticles,and others.We will focus on their classification,structures,synthesis,and intelligent features.These smart nanoparticles possess the ability to respond to various external and internal stimuli,such as enzymes,pH,temperature,optics,and magnetism,making them intelligent systems.Additionally,this review will explore the latest studies on tumor targeting by functionalizing the surfaces of smart nanoparticles with tumor-specific ligands like antibodies,peptides,transferrin,and folic acid.We will also summarize different types of drug delivery options,including small molecules,peptides,proteins,nucleic acids,and even living cells,for their potential use in cancer therapy.While the potential of smart nanoparticles is promising,we will also acknowledge the challenges and clinical prospects associated with their use.Finally,we will propose a blueprint that involves the use of artificial intelligence-powered nanoparticles in cancer treatment applications.By harnessing the potential of smart nanoparticles,this review aims to usher in a new era of precise and personalized cancer therapy,providing patients with individualized treatment options.