A new compound, named heteraltaic acid was isolated from the flowers of Heteropappus altaicus (willd) Novopokr.. The compound was elucidated as (5R, 6S, 8aS) –5- [2-(3-furyl ) ethyl-5, 6, 8a-trimethyl-4a, 5, 6, 7, 8,...A new compound, named heteraltaic acid was isolated from the flowers of Heteropappus altaicus (willd) Novopokr.. The compound was elucidated as (5R, 6S, 8aS) –5- [2-(3-furyl ) ethyl-5, 6, 8a-trimethyl-4a, 5, 6, 7, 8, 8a -hexahydro-1-naphthalenecarboxylic acid] by the combination of 1D and 2D NMR techniques (HSQC, HMBC) and X-ray analysis.展开更多
OBJECTIVE To enhance the quality and efficiency of chlorogeninc acid by investigating the differences among the chlorogeninc acid polymorphs in bioavailability and solubility.METHODS Determinative method was used to a...OBJECTIVE To enhance the quality and efficiency of chlorogeninc acid by investigating the differences among the chlorogeninc acid polymorphs in bioavailability and solubility.METHODS Determinative method was used to analyze the solubility of chlorogeninc acid polymorphs;solid chlorogeninc acid in different forms were orally administered to the rats,and a HPLC method was established to determinate plasma lever of metabolite-acyclovir and the bioavailability was analyzed.RESULTS The indirect pharmacokinetic parameters of Chlorogeninc acid,as the metabolites of the form Ⅰ,Ⅱ,Ⅲ,were as follows:cmaxwas 0.37,0.34 and 0.44mg·L-1,respectively;AUC0→twas 0.71,0.76 and 0.79mg·L-1·h,respectively.CONCLUSION The solubility of form Ⅲ was larger than the other forms′.The solubility of Chlorogeninc acid polymorphs:form Ⅰ,form Ⅱ,form Ⅲ were merely the same,there was no statistically significant difference in pharmacokinetic parameters among these three forms.展开更多
A novel cycloartane, named sphaerophysone A, 9, 19-cycloart-7b, 24b, 25-triol-1-en-3- one, was isolated from the ethanol extract of Sphaerophysa salsula DC. The structure was elucidated on the basis of spectral evide...A novel cycloartane, named sphaerophysone A, 9, 19-cycloart-7b, 24b, 25-triol-1-en-3- one, was isolated from the ethanol extract of Sphaerophysa salsula DC. The structure was elucidated on the basis of spectral evidences and confirmed by X-ray analysis, the stereochemistry of the compound was also defined by X-ray analysis.展开更多
文摘A new compound, named heteraltaic acid was isolated from the flowers of Heteropappus altaicus (willd) Novopokr.. The compound was elucidated as (5R, 6S, 8aS) –5- [2-(3-furyl ) ethyl-5, 6, 8a-trimethyl-4a, 5, 6, 7, 8, 8a -hexahydro-1-naphthalenecarboxylic acid] by the combination of 1D and 2D NMR techniques (HSQC, HMBC) and X-ray analysis.
基金The project supported by the Ministry of Science and Technology of China(2007FY130100)the 12th Five-Year Plan project(2012ZX09301002-001-013)
文摘OBJECTIVE To enhance the quality and efficiency of chlorogeninc acid by investigating the differences among the chlorogeninc acid polymorphs in bioavailability and solubility.METHODS Determinative method was used to analyze the solubility of chlorogeninc acid polymorphs;solid chlorogeninc acid in different forms were orally administered to the rats,and a HPLC method was established to determinate plasma lever of metabolite-acyclovir and the bioavailability was analyzed.RESULTS The indirect pharmacokinetic parameters of Chlorogeninc acid,as the metabolites of the form Ⅰ,Ⅱ,Ⅲ,were as follows:cmaxwas 0.37,0.34 and 0.44mg·L-1,respectively;AUC0→twas 0.71,0.76 and 0.79mg·L-1·h,respectively.CONCLUSION The solubility of form Ⅲ was larger than the other forms′.The solubility of Chlorogeninc acid polymorphs:form Ⅰ,form Ⅱ,form Ⅲ were merely the same,there was no statistically significant difference in pharmacokinetic parameters among these three forms.
文摘A novel cycloartane, named sphaerophysone A, 9, 19-cycloart-7b, 24b, 25-triol-1-en-3- one, was isolated from the ethanol extract of Sphaerophysa salsula DC. The structure was elucidated on the basis of spectral evidences and confirmed by X-ray analysis, the stereochemistry of the compound was also defined by X-ray analysis.
