Pre-pubertal periodontitis ( PPP) is a rare and rapidly progressive form ofearly onset periodontitis resulting in premature tooth loss of primary and permanent dentitions.Mutations in cathepsin C ( CTSC) gene have bee...Pre-pubertal periodontitis ( PPP) is a rare and rapidly progressive form ofearly onset periodontitis resulting in premature tooth loss of primary and permanent dentitions.Mutations in cathepsin C ( CTSC) gene have been found in patients with pre-pubertal periodontitisand Papillon-Lefevre syndrome which also characterized with severe periodontitis and palmoplantarhyperkera-tosis. To date, more than 40 mutations of CTSC gene have been identified in ethnicallydiverse people worldwide. However, there is no such genetic analysis in China. In the present study,we report the mutation analysis of a Chinese patient with PPP.展开更多
文摘Pre-pubertal periodontitis ( PPP) is a rare and rapidly progressive form ofearly onset periodontitis resulting in premature tooth loss of primary and permanent dentitions.Mutations in cathepsin C ( CTSC) gene have been found in patients with pre-pubertal periodontitisand Papillon-Lefevre syndrome which also characterized with severe periodontitis and palmoplantarhyperkera-tosis. To date, more than 40 mutations of CTSC gene have been identified in ethnicallydiverse people worldwide. However, there is no such genetic analysis in China. In the present study,we report the mutation analysis of a Chinese patient with PPP.
