Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter...Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter at the C3-position could be obtai ned exclusively with high yields(up to 95%)and excellent enantioselectivities(up to>99%).展开更多
A series of pyrazolone derivatives bearing a tetrasubstituted chiral center were prepared by virtue of a Lewis acid-catalyzed Friedel-Crafts reaction,in which a chiral copper complex was employed as the catalyst.This ...A series of pyrazolone derivatives bearing a tetrasubstituted chiral center were prepared by virtue of a Lewis acid-catalyzed Friedel-Crafts reaction,in which a chiral copper complex was employed as the catalyst.This reaction can be carried out smoothly under mild condition to afford the pyrazolone derivatives with high yields(up to 85%)and excellent enantioselectivities(up to 99%).In addition,the gram scale synthesis proved the practicality of this reaction.展开更多
文摘Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter at the C3-position could be obtai ned exclusively with high yields(up to 95%)and excellent enantioselectivities(up to>99%).
基金the financial support from the Natural Science Foundation of China(No.21772185)National Natural Science Foundation of China(No.22001241)supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)。
文摘A series of pyrazolone derivatives bearing a tetrasubstituted chiral center were prepared by virtue of a Lewis acid-catalyzed Friedel-Crafts reaction,in which a chiral copper complex was employed as the catalyst.This reaction can be carried out smoothly under mild condition to afford the pyrazolone derivatives with high yields(up to 85%)and excellent enantioselectivities(up to 99%).In addition,the gram scale synthesis proved the practicality of this reaction.
