The purpose of this study was to investigate the effects of salvianolic acid A(SAA) in systemic lupus erythematosus(SLE) induced by pristane in BALB/c mice.Lupus mice were established by confirming elevated levels of ...The purpose of this study was to investigate the effects of salvianolic acid A(SAA) in systemic lupus erythematosus(SLE) induced by pristane in BALB/c mice.Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane.Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls.The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin(H&E) and periodic acid-Schiff(PAS) staining.Western blot analysis of renal tissue was also employed.SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects.SAA treatment also significantly inhibited the phosphorylation of IKK,IκB and NFκB in renal tissues of lupus mice.In conclusion,the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK,IκB and NFκB.展开更多
It is significant for cell physiology to keep the homeostasis of p H, and it is highly demanded to develop ratiometric fluorescent sensors toward p H. In this work, under mild condition, through the electrostatic inte...It is significant for cell physiology to keep the homeostasis of p H, and it is highly demanded to develop ratiometric fluorescent sensors toward p H. In this work, under mild condition, through the electrostatic interaction between carbon nanodots（CDs） and organic molecules, two novel ratiometric fluorescence hybrid nanosensors were fabricated for sensing acidic p H. These nanohybrid systems possess dual emission peaks at 455 and 527 nm under a single excitation wavelength of 380 nm in acidic p H condition.With the increasing of p H, the fluorescence of the 1,8-naphthalimide derivative completely quenches,while the blue fluorescence of CDs keeps constant. Furthermore, the CDsàorganic molecular nanohybrids exhibit excellent anti-disturbance ability, reversible p H sensing ability, and a linear response range in wide p H range respectively. Besides the ability to target lysosome, with one of the nanosensor, stimulated p H change has been successfully tracked in a ratiometric manner via fluorescence imaging.展开更多
Long-lasting phosphorescent(LLP)materials have attracted considerable attention since green and blue emitting persistent Eu^(2+) doped alkaline earth phosphors were reported in the mid-1990s[1-3].Over the past few dec...Long-lasting phosphorescent(LLP)materials have attracted considerable attention since green and blue emitting persistent Eu^(2+) doped alkaline earth phosphors were reported in the mid-1990s[1-3].Over the past few decades,a considerable effort has been made to design novel LLP materials for a wide range of applications such as emergency lighting,interior decoration,road signs,and in vivo bioimaging[4-6].For these applications,long persistence times are often desirable.Two types of active center involved are:emitters展开更多
基金supported by the National Natural Science Foundation of China(Nos.81573645 and 81473383)National Scientific&Technological Major Special Project“Significant Creation of New Drugs”(Nos.2013ZX09103001-008,2012ZX09103101-078 and2013ZX09508104)
文摘The purpose of this study was to investigate the effects of salvianolic acid A(SAA) in systemic lupus erythematosus(SLE) induced by pristane in BALB/c mice.Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane.Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls.The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin(H&E) and periodic acid-Schiff(PAS) staining.Western blot analysis of renal tissue was also employed.SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects.SAA treatment also significantly inhibited the phosphorylation of IKK,IκB and NFκB in renal tissues of lupus mice.In conclusion,the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK,IκB and NFκB.
基金supports from National Natural Science Foundation of China (Nos. 21601158, U1504203 and J1210060)Key Laboratory of Photochemical Conversion and Optoelectronic Materials and Zhengzhou University
文摘It is significant for cell physiology to keep the homeostasis of p H, and it is highly demanded to develop ratiometric fluorescent sensors toward p H. In this work, under mild condition, through the electrostatic interaction between carbon nanodots（CDs） and organic molecules, two novel ratiometric fluorescence hybrid nanosensors were fabricated for sensing acidic p H. These nanohybrid systems possess dual emission peaks at 455 and 527 nm under a single excitation wavelength of 380 nm in acidic p H condition.With the increasing of p H, the fluorescence of the 1,8-naphthalimide derivative completely quenches,while the blue fluorescence of CDs keeps constant. Furthermore, the CDsàorganic molecular nanohybrids exhibit excellent anti-disturbance ability, reversible p H sensing ability, and a linear response range in wide p H range respectively. Besides the ability to target lysosome, with one of the nanosensor, stimulated p H change has been successfully tracked in a ratiometric manner via fluorescence imaging.
基金supported by the National Natural Science Foundation of China(Grant Nos.21301023,11204024,and 11474046)Program for New Century Excellent Talents in University(Grant No.NCET-13-0702)+3 种基金Science and Technology Project of Liaoning Province(Grant No.2012222009)Natural Science Foundation of Liaoning Province(Grant No.20170540200)Fundamental Research Funds for the Central Universities(Grant Nos.DC201502080302,DC201502080406,DC201502080203,DCPY2016009,and DCPY2016026)Technology Foundation for Selected Overseas Chinese Scholar,Ministry of Human Resources and Social Security of the People’s Republic of China
文摘Long-lasting phosphorescent(LLP)materials have attracted considerable attention since green and blue emitting persistent Eu^(2+) doped alkaline earth phosphors were reported in the mid-1990s[1-3].Over the past few decades,a considerable effort has been made to design novel LLP materials for a wide range of applications such as emergency lighting,interior decoration,road signs,and in vivo bioimaging[4-6].For these applications,long persistence times are often desirable.Two types of active center involved are:emitters
