Dear Editor,Since severe acute respiratory syndrome coronavirus 2(SARSCoV-2)RNA has been detected in human breastmilk,infants’safety with breastmilk feeding is of great concern for women with coronavirus disease 2019...Dear Editor,Since severe acute respiratory syndrome coronavirus 2(SARSCoV-2)RNA has been detected in human breastmilk,infants’safety with breastmilk feeding is of great concern for women with coronavirus disease 2019(COVID-19).1 It is known that milk has antiviral properties.2 However,little is known about the antiviral property of human breastmilk to SARS-CoV-2 and its related pangolin coronavirus(GX_P2V).Here we present for the first time that whey protein from human breastmilk effectively inhibited both SARS-CoV-2 and GX_P2V by blocking viral attachment and viral replication at entry and even post entry.Moreover,human whey protein inhibited infectious virus production,as proved by the plaque assay.We found that whey protein from different species,such as cow and goat,also showed anti-coronavirus properties.Commercial bovine formula milk also showed similar anti-SARS-CoV-2 activity.展开更多
In a recent study published on Nature Medicine,Isidro,J et al.attempted to explore the potential causes of the recent monkeypox outbreak in 2022,1 which has been declared as a Public Health Emergency of International ...In a recent study published on Nature Medicine,Isidro,J et al.attempted to explore the potential causes of the recent monkeypox outbreak in 2022,1 which has been declared as a Public Health Emergency of International Concern(PHEIC).The genetic characterization study based on shotgun metagenomics suggested that the mutational bias(from GA to AA or TC to TT)in monkeypox genomes driven by apolipoprotein B mRNAediting catalytic polypeptide-like 3(APOBEC3)enzyme might account for the PHEIC.展开更多
基金We thank Prof.Youchun Wang and Weijin Huang(National Institutes for Food and Drug Control,China)for sharing the pseudovirus of SARS-CoV-2.We thank Xiaoyun Liu(Peking University Health Science Center)for helpful discussion.K.X.and Y.-H.Z.declare grants from the National Natural Science Foundation of China[Grant No.81802002 and 81873579(to K.X.)81672002(to Y.-H.Z.)].K.X.declares grants from the Peking University Medicine Fund of Fostering Young Scholars’Scientific&Technological Innovation(Grant No.BMU2017YB001).Y.T.declares grants from the Funds for First-class Discipline Construction(XK1805),Key Project of Beijing University of Chemical Technology(No.XK1803-06),and Fundamental Research Funds for Central Universities(No.BUCTRC201917).H.F.declares grants from the Fundamental Research Funds for Central Universities(No.BUCTZY2022).
文摘Dear Editor,Since severe acute respiratory syndrome coronavirus 2(SARSCoV-2)RNA has been detected in human breastmilk,infants’safety with breastmilk feeding is of great concern for women with coronavirus disease 2019(COVID-19).1 It is known that milk has antiviral properties.2 However,little is known about the antiviral property of human breastmilk to SARS-CoV-2 and its related pangolin coronavirus(GX_P2V).Here we present for the first time that whey protein from human breastmilk effectively inhibited both SARS-CoV-2 and GX_P2V by blocking viral attachment and viral replication at entry and even post entry.Moreover,human whey protein inhibited infectious virus production,as proved by the plaque assay.We found that whey protein from different species,such as cow and goat,also showed anti-coronavirus properties.Commercial bovine formula milk also showed similar anti-SARS-CoV-2 activity.
基金supported by the National Key Research and Development Program of China(grant no.2022YFC0867500,2020YFA0712102,BWS21J025,and 20SWAQK22)National Natural Science Foundation of China(grant no.82202492,82151224)+2 种基金Fundamental Research Funds for Central Universities(grant no.BUCTZY2022)H&H Global Research and Technology Center(grant no.H2021028)National College Students’Innovation and Entrepreneurship Training Program(grant no.202210010040).
文摘In a recent study published on Nature Medicine,Isidro,J et al.attempted to explore the potential causes of the recent monkeypox outbreak in 2022,1 which has been declared as a Public Health Emergency of International Concern(PHEIC).The genetic characterization study based on shotgun metagenomics suggested that the mutational bias(from GA to AA or TC to TT)in monkeypox genomes driven by apolipoprotein B mRNAediting catalytic polypeptide-like 3(APOBEC3)enzyme might account for the PHEIC.
